Amelioration of aspirin induced oxidative impairment and apoptotic cell death by a novel antioxidant protein molecule isolated from the herb Phyllanthus niruri

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Bhattacharyya, Sudip ^a   Ghosh, Shatadal ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIOXIDANT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHYLLANTHUS NIRURI PROTEIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; ANTIOXIDANT;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; HERB; HISTOPATHOLOGY; LIVER TOXICITY; MALE; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PHYLLANTHUS NIRURI; PROTEIN ISOLATION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; SPLEEN; TOXICITY; ANIMAL; CELL PROTECTION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ISOLATION AND PURIFICATION; PHYLLANTHUS;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASPIRIN; CELL DEATH; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MALE; MICE; OXIDATIVE STRESS; PHYLLANTHUS; PLANT PROTEINS;

EID: 84896775675     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089026     Document Type: Article

References (75)

1. Giardina C, Inan MS (1998) Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1401: 277-288. (Pubitemid 28122345)
2. Mingatto FE, Santos AC, Uyemura SA, Jordani MC, Curti C (1996) In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: respiration and ATP synthesis. Arch Biochem Biophys 334: 303-308. (Pubitemid 26347313)
3. Giovannucci E, Egan KM, Hunter DJ, Stampfer MJ, Colditz GA, et al. (1995) Aspirin and the risk of colorectal cancer in women. N Engl J Med 333: 609-614.
4. Dreser H (1899) Pharmakologisches über Aspirin (Acetylsalicylsä ure). Pflüger, Archiv für die Gesammte Physiologie des Menschen und der Thiere 76: 306-318.
5. Piazza GA, Rahm AK, Finn TS, Fryer BH, Li H, et al. (1997) Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction. Cancer Res 57: 2452-2459. (Pubitemid 27255906)
6. Jana NR (2008) NSAIDs and apoptosis. Cell Mol Life Sci 65: 1295-1301.
7. Vane JR, Botting RM (2003) The mechanism of action of aspirin. Thromb Res 110: 255-258. (Pubitemid 37329821)
8. Suzuki Y, Inoue T, Ra C (2010) NSAIDs, Mitochondria and Calcium Signaling: Special Focus on Aspirin/Salicylates. Pharmaceuticals 3: 1594-1613.
9. Hossain MA, Kim DH, Jang JY, Kang YJ, Yoon JH, et al. (2012) Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. Int J Oncol 40: 1636-1642.
10. Becker JC, Domschke W, Pohle T (2004) Current approaches to prevent NSAID-induced gastropathy-COX selectivity and beyond. Br J Clin Pharmacol 58: 587-600. (Pubitemid 39665146)
11. Manna P, Sinha M, Sil PC (2007) Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic Clin Pharmacol Toxicol 101: 333-338. (Pubitemid 47512390)
12. Ghosh J, Das J, Manna P, Sil PC (2008) Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. Toxicol In Vitro 22: 1918-1926.
13. Ghosh J, Das J, Manna P, Sil PC (2011) The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis. Biomaterials 32: 4857-4866.
14. Manna P, Das J, Ghosh J, Sil PC (2010) Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. Free Radic Biol Med 48: 1465-1484.
15. Manna P, Ghosh J, Das J, Sil PC (2010) Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: protective role of arjunolic acid. Toxicol Appl Pharmacol 244: 114-129.
16. Ghosh J, Das J, Manna P, Sil PC (2010) Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection. Free Radic Biol Med 48: 535-553.
17. Ghosh J, Das J, Manna P, Sil PC (2010) Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: therapeutic potential of arjunolic acid. Toxicology 268: 8-18.
18. Sarkar K, Sil PC (2006) A 43 kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes. Toxicol In Vitro 20: 634-640. (Pubitemid 43833268)
19. Pal S, Sil PC (2012) A 43 kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependent and independent pathways. Biochimie 94: 1356-1367.
20. Manna P, Bhattacharyya S, Das J, Ghosh J, Sil PC (2011) Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evid Based Complement Alternat Med 2011: 832805.
21. Sarkar MK, Kinter M, Mazumder B, Sil PC (2009) Purification and characterisation of a novel antioxidant protein molecule from Phyllanthus niruri. Food Chemistry 114: 1405-1412.
22. Khatoon S, Rai V, Rawat AK, Mehrotra S (2006) Comparative pharmacognostic studies of three Phyllanthus species. J Ethnopharmacol 104: 79-86. (Pubitemid 43234084)
23. Chatterjee M, Sarkar K, Sil PC (2006) Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Pathophysiology 13: 95-102.
24. Nishiura JL, Campos AH, Boim MA, Heilberg IP, Schor N (2004) Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol Res 32: 362-366. (Pubitemid 39517961)
25. Raphael KR, Kuttan R (2003) Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract. J Ethnopharmacol 87: 193-197. (Pubitemid 36809150)
26. Devi M, Satyanarayana S, Rao A (1986) Effect of Phyllantus niruri on the diuretic activity of Punarnava tablets. J Res Edu Med 1986; 5: 11 12.
27. Thyagarajan S, Thirunalasundari T, Subramanian S, Venkateswaran P, Blumberg B (1988) Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. The Lancet 332: 764-766.
28. Harish R, Shivanandappa T (2006) Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chemistry 95: 180-185. (Pubitemid 41338153)
29. Cheng JT, Lin TC, Hsu FL (1995) Antihypertensive effect of corilagin in the rat. Can J Physiol Pharmacol 73: 1425-1429.
30. Chatterjee M, Sil PC (2006) Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian J Biochem Biophys 43: 299-305.
31. Bhattacharjee R, Sil PC (2006) Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity. Biomedical Research 17: 75-79.
32. Sarkar MK, Sil PC (2007) Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity. Pathophysiology 14: 113-120. (Pubitemid 47554503)
33. Sarkar MK, Sil PC (2010) Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri. Toxicol In Vitro 24: 1711-1719.
34. Bhattacharyya S, Pal PB, Sil PC (2013) A 35 kD Phyllanthus niruri protein modulates iron mediated oxidative impairment to hepatocytes via the inhibition of ERKs, p38 MAPKs and activation of PI3k/Akt pathway. Food Chem Toxicol 56: 119-130.
35. Bhattacharjee R, Sil PC (2006) The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytotherapy Research 20: 595-601. (Pubitemid 44065144)
36. Bhattacharjee R, Sil PC (2007) Protein isolate from the herb, Phyllanthus niruri L.(Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food and Chemical Toxicology 45: 817-826. (Pubitemid 46463992)
37. Kind PR, King EJ (1954) Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J Clin Pathol 7: 322-326.
38. Rashid K, Bhattacharya S, Sil PC (2012) Protective role of D-saccharic acid-1,4-lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway. Free Radic Res 46: 240-252.
39. Ghosh M, Manna P, Sil PC (2011) Protective role of a coumarin-derived schiff base scaffold against tertiary butyl hydroperoxide (TBHP)-induced oxidative impairment and cell death via MAPKs, NF-kappaB and mitochondriadependent pathways. Free Radic Res 45: 620-637.
40. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82: 70-77.
41. Benzie IF, Strain JJ (1999) Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 299: 15-27. (Pubitemid 28483878)
42. Das J, Ghosh J, Manna P, Sil PC (2010) Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res 44: 340-355.
43. Ramadas D, Srinivas L (2011) Antioxidant effects of 28 kDa antioxidant protein from turmeric (Curcuma longa L). Asian Journal of Pharmaceutical and Clinical Research 4: 119-123.
44. Ahmed H, EL Zahab HA, Alswiai G (2013) Purification of antioxidant protein isolated from Peganum harmala and its protective effect against CCl4 toxicity in rats. Turkish Journal of Biology 37: 39-48.
45. Angel G, Vimala B, Nambisan B (2013) Antioxidant and anti-inflammatory activities of proteins isolated from eight Curcuma species. J Phytopharmacology 4: 96-105.
46. Sivapriya M, Leela S (2007) Isolation and purification of a novel antioxidant protein from the water extract of Sundakai (Solanum torvum) seeds. Food chemistry 104: 510-517. (Pubitemid 46661053)
47. Oh P-S, Lim K-T (2006) Plant originated glycoprotein has anti-oxidative and anti-inflammatory effects on dextran sulfate sodium-induced colitis in mouse. Journal of biomedical science 13: 549-560.
48. Lee SJ, Oh PS, Ko JH, Lim KT, Lim K (2006) Protective effect of glycoprotein isolated from Ulmus davidiana Nakai on carbon tetrachloride-induced mouse liver injury. Journal of pharmacy and pharmacology 58: 143-152.
49. Adachi M, Sakamoto H, Kawamura R, Wang W, Imai K, et al. (2007) Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells. Histol Histopathol 22: 437-442. (Pubitemid 46647257)
50. Garber E, Craig RM, Bahu RM (1975) Letter: Aspirin hepatotoxicity. Ann Intern Med 82: 592-593.
51. Bessone F (2010) Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage? World J Gastroenterol 16: 5651-5661.
52. Athreya BH, Gorske AL, Myers AR (1973) Aspirin-induced abnormalities of liver function. Am J Dis Child 126: 638-641.
53. Manov I, Motanis H, Frumin I, Iancu TC (2006) Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta Pharmacol Sin 27: 259-272. (Pubitemid 43357020)
54. Lopez-Morante AJ, Saez-Royuela F, Diez-Sanchez V, Martin-Lorente JL, Yuguero L, et al. (1993) Aspirin-induced cholestatic hepatitis. J Clin Gastroenterol 16: 270-272.
55. Das J, Ghosh J, Manna P, Sil PC (2010) Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. PLoS One 5: e12602.
56. Lanas A, Polo-Tomas M, Casado-Arroyo R (2013) The aspirin cardiovascular/gastrointestinal risk calculator-a tool to aid clinicians in practice. Aliment Pharmacol Ther 37: 738-748.
57. Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, et al. (2009) Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373: 1849-1860.
58. Mehta SR, Bassand JP, Chrolavicius S, Diaz R, Eikelboom JW, et al. (2010) Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med 363: 930-942.
59. De Berardis G, Sacco M, Strippoli GF, Pellegrini F, Graziano G, et al. (2009) Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ 339: b4531.
60. Sung JJ, Lau JY, Ching JY, Wu JC, Lee YT, et al. (2010) Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial. Ann Intern Med 152: 1-9.
61. Davenport HW (1967) Salicylate damage to the gastric mucosal barrier. N Engl J Med 276: 1307-1312.
62. Dalle-Donne I, Aldini G, Carini M, Colombo R, Rossi R, et al. (2006) Protein carbonylation, cellular dysfunction, and disease progression. J Cell Mol Med 10: 389-406. (Pubitemid 44870187)
63. Li WG, Stoll LL, Rice JB, Xu SP, Miller FJ Jr, et al. (2003) Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. Free Radic Biol Med 34: 937-946. (Pubitemid 36316078)
64. Baeuerle PA, Baltimore D (1996) NF-kappa B: ten years after. Cell 87: 13-20.
65. McCarty MF, Block KI (2006) Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy. Integr Cancer Ther 5: 252-268.
66. Kim KM, Song JJ, An JY, Kwon YT, Lee YJ (2005) Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem 280: 41047-41056. (Pubitemid 41780600)
67. Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396: 77-80. (Pubitemid 28520452)
68. Kim BJ, Ryu SW, Song BJ (2006) JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 281: 21256-21265.
69. Sinha K, Das J, Pal PB, Sil PC (2013) Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 87: 1157-1180.
70. Kopp E, Ghosh S (1994) Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265: 956-959.
71. Bhattacharyya S, Ghosh J, Sil PC (2012) Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: beneficial role of glycine. Free Radic Res 46: 1296-1307.
72. Bellosillo B, Pique M, Barragan M, Castano E, Villamor N, et al. (1998) Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood 92: 1406-1414. (Pubitemid 28369055)
73. Gu Q, Wang JD, Xia HH, Lin MC, He H, et al. (2005) Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis 26: 541-546. (Pubitemid 41214142)
74. Wang J, Ito T, Udaka N, Okudela K, Yazawa T, et al. (2005) PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung. Tissue Cell 37: 25-35. (Pubitemid 40214725)
75. Rameh LE, Cantley LC (1999) The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274: 8347-8350. (Pubitemid 29164617)