Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated h-bonding network

Journal of Biological Chemistry

Volumn 289, Issue 10, 2014, Pages 6799-6808

  Xu, Shu ^a   Hermanson, Daniel J ^a   Banerjee, Surajit ^b,c   Ghebreselasie, Kebreab ^a   Clayton, Gina M ^d   Garavito, R Michael ^d   Marnett, Lawrence J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

ACTIVE SITE; ANTI-INFLAMMATORY DRUGS; BINDING POCKETS; CYCLOOXYGENASES; H-BONDING NETWORKS; MELOXICAM; OXICAMS; STRUCTURAL DESCRIPTIONS;

COMPLEX NETWORKS;

AMIDE; ARGININE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HYDROGEN; HYDROXYL GROUP; ISOLEUCINE; ISOXICAM; LEUCINE; MELOXICAM; NITROGEN; NONSTEROID ANTIINFLAMMATORY AGENT; OXICAM DERIVATIVE; PHENYLALANINE; SERINE; THIAZINE DERIVATIVE; TYROSINE; VALINE; WATER;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENE MUTATION; HYDROGEN BOND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; X RAY CRYSTALLOGRAPHY;

CYCLOOXYGENASE (COX) PATHWAY; DRUG ACTION; ENZYME STRUCTURE; PROTEIN DRUG INTERACTIONS; X-RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARGININE; BINDING SITES; CATALYTIC DOMAIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; HYDROGEN BONDING; LEUCINE; MICE; MUTATION; PIROXICAM; PROTEIN STRUCTURE, SECONDARY; SERINE; THIAZINES; THIAZOLES; TYROSINE; WATER;

EID: 84896765443     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.517987     Document Type: Article

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