Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity

Journal of Medicinal Chemistry

Volumn 40, Issue 6, 1997, Pages 980-989

  Lazer, Edward S ^a   Miao, Clara K ^a   Cywin, Charles L ^a   Sorcek, Ronald ^a   Wong, Hin Chor ^a   Meng, Zhaoxing ^a   Potocki, Ian ^a   Hoermann, MaryAnn ^a   Snow, Roger J ^a   Tschantz, Matt A ^a   Kelly, Terence A ^a   McNeil, Daniel W ^a   Coutts, Simon J ^a   Churchill, Laurie ^a   Graham, Anne G ^a   David, Eva ^a   Grob, Peter M ^a   Engel, Wolfhard ^a,b   Meier, Hans ^a,b   Trummlitz, Günter ^a,b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; THIAZINE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; INFLAMMATION; PROSTAGLANDIN SYNTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZINES; THIAZOLES;

EID: 14444275534     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9607010     Document Type: Article

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