Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in wistar rats

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Cheng, Kai Chun ^a   Asakawa, Akihiro ^a   Li, Ying Xiao ^a   Chung, Hsien Hui ^b   Amitani, Haruka ^a   Ueki, Takatoshi ^c   Cheng, Juei Tang ^d   Inui, Akio ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SILYMARIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; MALE; MYOTUBE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CELL LINE; DIET; GENE DELETION; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INSULIN RESISTANCE; MALE; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; PTEN PHOSPHOHYDROLASE; RATS; SIGNAL TRANSDUCTION; SILYMARIN;

EID: 84896760548     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084550     Document Type: Article

References (54)

1. Contos MJ, Choudhury J, Mills AS, Sanyal AJ (2004) The histologic spectrum of nonalcoholic fatty liver disease. Clin Liver Dis 8: 481-500. (Pubitemid 39141138)
2. Marchesini G, Babini M (2006) Nonalcoholic fatty liver disease and the metabolic syndrome. Minerva Cardioangiol 54: 229-239. (Pubitemid 43974287)
3. Williams R (2006) Global challenges in liver disease. Hepatology 44: 521-526. (Pubitemid 44433707)
4. Flora K, Hahn M, Rosen H, Benner K (1998) Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 93: 139-143. (Pubitemid 29063954)
5. Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA (2002) Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am J Med 113: 506-515. (Pubitemid 35335804)
6. Lieber CS, Leo MA, Cao Q, Ren C, DeCarli LM (2003) Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. J Clin Gastroenterol 37: 336-339. (Pubitemid 37158997)
7. Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, et al. (2002) Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res 62: 3063-3069. (Pubitemid 34602396)
8. Singh RP, Gu M, Agarwal R (2008) Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res 68: 2043-2050. (Pubitemid 351416592)
9. Singh RP, Sharma G, Dhanalakshmi S, Agarwal C, Agarwal R (2003) Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis. Cancer Epidemiol Biomarkers Prev 12: 933-939. (Pubitemid 37151532)
10. Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R (2008) Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving downregulation of survivin. Clin Cancer Res 14: 300-308. (Pubitemid 351378006)
11. Tyagi A, Agarwal C, Agarwal R (2002) Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention. Mol Cancer Ther 1: 525-532.
12. Tyagi A, Bhatia N, Condon MS, Bosland MC, Agarwal C, et al. (2002) Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells. Prostate 53: 211-217. (Pubitemid 35266181)
13. Lah JJ, Cui W, Hu KQ (2007) Effects and mechanisms of silibinin on human hepatoma cell lines. World J Gastroenterol 13: 5299-5305. (Pubitemid 47559458)
14. Varghese L, Agarwal C, Tyagi A, Singh RP, Agarwal R (2005) Silibinin efficacy against human hepatocellular carcinoma. Clin Cancer Res 11: 8441-8448. (Pubitemid 41746959)
15. Peyrou M, Bourgoin L, Foti M (2010) PTEN in liver diseases and cancer. World J Gastroenterol 16: 4627-4633.
16. Wang L, Wang WL, Zhang Y, Guo SP, Zhang J, et al. (2007) Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma. Hepatol Res 37: 389-396. (Pubitemid 46605424)
17. Vinciguerra M, Foti M (2006) PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling. Arch Physiol Biochem 112: 89-104. (Pubitemid 44384777)
18. Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, et al. (2005) Muscle specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 25: 1135-1145. (Pubitemid 40165819)
19. Butler M, McKay RA, Popoff IJ, Gaarde WA, Witchell D, et al. (2002) Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes 51: 1028-1034. (Pubitemid 34438346)
20. Chiu YJ, Chung HH, Yeh CH, Cheng JT, Lo SH (2011) Improvement of Insulin Resistance by Chlorella in Fructose-rich Chow-fed Rats. Phytother Res 25: 1306-1312.
21. Wang X, Ge A, Cheng M, Guo F, Zhao M, et al. (2012) Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to highfat diet. Exp Diabetes Res 2012: 847246.
22. Bu Z, Kuok K, Meng J, Wang R, Xu B, et al. (2012) The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level. Reprod Biol Endocrinol 10: 10.
23. Su CH, Liu IM, Chung HH, Cheng JT (2009) Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats. Neurosci Lett 457: 125-128.
24. Steele R (1959) Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 82: 420-430.
25. Wang SH, Kao MY, Wu SC, Lo DY, Wu JY, et al. (2011) Oral administration of Trapa taiwanensis Nakai fruit skin extracts conferring hepatoprotection from CCl4-caused injury. J Agric Food Chem 59: 3686-3692.
26. Alonso-Castro AJ, Zapata-Bustos R, Domínguez F, García-Carrancá A, Salazar-Olivo LA (2011) Magnolia dealbata Zucc and its active principles honokiol and magnolol stimulate glucose uptake in murine and human adipocytes using the insulin-signaling pathway. Phytomedicine 18: 926-933.
27. Zu L, Shen Z, Wesley J, Cai ZP (2011) PTEN inhibitors cause a negative inotropic and chronotropic effect in mice. Eur J Pharmacol 650: 298-302.
28. Wedin WK, Diaz-Gimenez L, Convit AJ (2012) Prediction of insulin resistance with anthropometric measures: lessons from a large adolescent population. Diabetes Metab Syndr Obes 5: 219-225.
29. Kamezaki F, Sonoda S, Nakata S, Kashiyama K, Muraoka Y, et al. (2012) Proposed cutoff level of waist circumference in Japanese men: evaluation by homeostasis model assessment of insulin resistance levels. Intern Med 51: 2119-2124.
30. Zhao D, McCully BH, Brooks VL (2012) Rosiglitazone improves insulin sensitivity and baroreflex gain in rats with diet-induced obesity. J Pharmacol Exp Ther 343: 206-213.
31. Zhang Z, Sheng S, Guo L, Li G, Zhang L, et al. (2012) Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats. Mol Cell Endocrinol 361: 213-218.
32. Nandhini AT, Thirunavukkarasu V, Ravichandran MK, Anuradha CV (2005) Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats. Singapore Med J 46: 82-87. (Pubitemid 40203743)
33. Hawke RL, Schrieber SJ, Soule TA, Wen Z, Smith PC, et al. (2010) Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C. J Clin Pharmacol 50: 434-449.
34. Schrieber SJ, Hawke RL, Wen Z, Smith PC, Reddy KR, et al. (2011) Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C. Drug Metab Dispos. 39: 2182-2190.
35. Leber HW, Knauff S (1976) Influence of silymarin on drug metabolizing enzymes in rat and man. Arzneimittelforschung. 26: 1603-1605.
36. Khan RA, Khan MR, Ahmed M, Sahreen S, Shah NA, et al. (2012) Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats. BMC Complement Altern Med 12: 114.
37. Tzeng JI, Chen MF, Chung HH, Cheng JT (2012) Silymarin Decreases Connective Tissue Growth Factor to Improve Liver Fibrosis in Rats Treated with Carbon Tetrachloride. Phytother Res 27: 1023-1028.
38. Vengerovskii AI, Khazanov VA, Eskina KA, Vasilyev KY (2007) Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus. Bull Exp Biol Med 144: 53-56. (Pubitemid 350142485)
39. Vessal G, Akmali M, Najafi P, Moein MR, Sagheb MM (2010) Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats. Renal Fail 32: 733-739.
40. Ashkavand Z, Malekinejad H, Amniattalab A, Rezaei-Golmisheh A, Vishwanath BS (2012) Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. Phytomedicine 19: 1200-1205.
41. Cecen E, Dost T, Culhaci N, Karul A, Ergur B, et al. (2011) Protective effects of silymarin against doxorubicin-induced toxicity. Asian Pac J Cancer Prev 12: 2697-2704.
42. Baluchnejadmojarad T, Roghani M, Khastehkhodaie Z (2010) Chronic treatment of silymarin improves hyperalgesia and motor nerve conduction velocity in diabetic neuropathic rat. Phytother Res 24: 1120-1125.
43. Malekinejad H, Rezabakhsh A, Rahmani F, Hobbenaghi R (2012) Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats. Phytomedicine 19: 583-590.
44. Mak LH, Vilar R, Woscholski R (2010) Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol 3: 157-163.
45. Alexandrov IM, Ivshina M, Jung DY, Friedline R, Ko HJ, et al. (2012) Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. PLoS Genet 8: e1002457.
46. Lee SK, Lee JO, Kim JH, Kim SJ, You GY, et al. (2011) Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells. J Cell Biochem 112: 1259-1267.
47. DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J (1983) Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32: 35-45. (Pubitemid 13203694)
48. Sarabia V, Lam L, Burdett E, Leiter LA, Klip A (1992) Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin. J Clin Invest 90: 1386-1395.
49. Landau BR, Spring-Robinson CL, Muzic RF Jr, Rachdaoui N, Rubin D, et al. (2007) 6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport. Am J Physiol Endocrinol Metab 2007; 293: 237-245.
50. Blodgett AB, Kothinti RK, Kamyshko I, Petering DH, Kumar S, et al. (2011) A fluorescence method for measurement of glucose transport in kidney cells. Diabetes Technol Ther 13: 743-751.
51. Zou C, Wang Y, Shen Z (2005) 2-NBDG as a fluorescent indicator for direct glucose uptake measurement. J Biochem Biophys Methods 64: 207-215. (Pubitemid 41393730)
52. Louzao MC, Espiña B, Vieytes MR, Vega FV, Rubiolo JA, et al. (2008) "Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection. Glycoconj J 25: 503-510.
53. Alonso-Castro AJ, Salazar-Olivo LA (2008) The anti-diabetic properties of Guazuma ulmifolia Lam are mediated by the stimulation of glucose uptake in normal and diabetic adipocytes without inducing adipogenesis. J Ethnopharmacol 118: 252-256.
54. Yu HC, Chen LJ, Cheng KC, Li YX, Yeh CH, et al. (2012) Silymarin inhibits cervical cancer cell through an increase of phosphatase and tensin homolog. Phytother Res 26: 709-715.