PTEN inhibitors cause a negative inotropic and chronotropic effect in mice

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 298-302

  Zu, Lingyun ^a,b   Shen, Zhenyun ^b   Wesley, Jacob ^c   Cai, Zheqing P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Cardiac contractility; Myocardial infarction; PI3K; PTEN; Reperfusion injury

Indexed keywords

ESTERASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE INHIBITOR; POTASSIUM BISPEROXO(1,10 PHENANTHROLINE)OXOVANADATE; UNCLASSIFIED DRUG; VANADYLHYDROXYPICOLINIC ACID 5 HYDROXYPYRIDINE 2 CARBOXYL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART RATE; IN VIVO STUDY; INOTROPISM; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; SYSTOLIC BLOOD PRESSURE;

ANIMALS; CARDIOTONIC AGENTS; ENZYME ACTIVATION; ENZYME INHIBITORS; HEART; HEART RATE; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECOVERY OF FUNCTION; REPERFUSION INJURY;

EID: 78649740716     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.09.069     Document Type: Article

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