Silymarin inhibits cervical cancer cell through an increase of phosphatase and tensin homolog

Phytotherapy Research

Volumn 26, Issue 5, 2012, Pages 709-715

  Yu, Hann Chin ^a   Chen, Li Jen ^b   Cheng, Kai Chun ^c   Li, Ying Xiao ^c   Yeh, Ching Hua ^d   Cheng, Juei Tang ^b,d,e  

^a Zhudong Veterans Hospital   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^e CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

apoptosis; C 33A; cell invasion; cell migration; cervical cancer cell; PTEN; silymarin

Indexed keywords

CASPASE 3; GELATINASE B; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN KINASE B; SILYMARIN; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL INVASION; CELL MIGRATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FAMILY; PTEN GENE; UTERINE CERVIX CANCER; WESTERN BLOTTING; WOUND HEALING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; GENES, BCL-2; HUMANS; MATRIX METALLOPROTEINASE 9; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SILYMARIN; UTERINE CERVICAL NEOPLASMS; WOUND HEALING;

SILYBUM MARIANUM;

EID: 84859902267     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3618     Document Type: Article

References (37)

1. Agarwal C, Singh RP, Dhanalakshmi S, et al,. 2003. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 22 (51): 8271-8282. (Pubitemid 37485520)
2. Cai Z, Korner M, Tarantino N, Chouaib S,. 1997. IkappaB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-kappaB activation but not tumor necrosis factor-alpha-induced apoptosis. J Biol Chem 272 (1): 96-101. (Pubitemid 27021130)
3. Cantley LC, Neel BG,. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 96 (8): 4240-4245. (Pubitemid 29190320)
4. Chen PN, Hsieh YS, Chiang CL, Chiou HL, Yang SF, Chu SC,. 2006. Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway. J Dent Res 85 (3): 220-225.
5. Chu SC, Chiou HL, Chen PN, Yang SF, Hsieh YS,. 2004. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog 40 (3): 143-149.
6. Chung JH, Eng C,. 2005. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res 65 (18): 8096-8100. (Pubitemid 41330571)
7. Cui W, Gu F, Hu KQ,. 2009. Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice. World J Gastroenterol 15 (16): 1943-1950.
8. Fang Y, Svoboda KK,. 2005. Nicotine inhibits human gingival fibroblast migration via modulation of Rac signalling pathways. J Clin Periodontol 32 (12): 1200-1207. (Pubitemid 41729547)
9. Feher J, Lengyel G,. 2008. Silymarin in the treatment of chronic liver diseases: past and future. Orv Hetil 149 (51): 2413-2418.
10. Franke TF, Cantley LC,. 1997. Apoptosis. A Bad kinase makes good. Nature 390 (6656): 116-117. (Pubitemid 27507959)
11. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C,. 2003. PI3K/Akt and apoptosis: size matters. Oncogene 22 (56): 8983-8998. (Pubitemid 38121699)
12. Furukawa K, Kumon Y, Harada H, et al,. 2006. PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules. Int J Oncol 29 (1): 73-81.
13. Kanamori Y, Kigawa J, Itamochi H, et al,. 2001. Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma. Clin Cancer Res 7 (4): 892-895. (Pubitemid 32708726)
14. Katiyar SK,. 2002. Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol 21 (6): 1213-1222.
15. Katiyar SK, Roy AM, Baliga MS,. 2005. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ther 4 (2): 207-216. (Pubitemid 40340200)
16. Kaur M, Velmurugan B, Tyagi A, Agarwal C, Singh RP, Agarwal R,. 2010. Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia 12 (5): 415-424.
17. Kroll DJ, Shaw HS, Oberlies NH,. 2007. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther 6 (2): 110-119. (Pubitemid 46871844)
18. Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C,. 2001. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas. Am J Pathol 158 (6): 2097-2106. (Pubitemid 32545195)
19. Lah JJ, Cui W, Hu KQ,. 2007. Effects and mechanisms of silibinin on human hepatoma cell lines. World J Gastroenterol 13 (40): 5299-5305. (Pubitemid 47559458)
20. Lien HM, Lin HW, Wang YJ, et al,. 2009. Inhibition of anchorage-independent proliferation and G0/G1 cell-cycle regulation in human colorectal carcinoma cells by 4,7-dimethoxy-5-methyl-l,3-benzodioxole Isolated from the fruiting body of Antrodia camphorate. Evid Based Complement Alternat Medicine. 1-10. DOI: 10.1093/eCAM/nep020.
21. Lu Y, Lin YZ, LaPushin R, et al,. 1999. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene 18 (50): 7034-7045. (Pubitemid 30028874)
22. Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB,. 1999. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. J Immunol 163 (12): 6800-6809.
23. Matsuda T, Ferreri K, Todorov I, et al,. 2005. Silymarin protects pancreatic beta-cells against cytokine-mediated toxicity: implication of c-Jun NH2-terminal kinase and janus kinase/signal transducer and activator of transcription pathways. Endocrinology 146 (1): 175-185. (Pubitemid 40051737)
24. McCubrey JA, Steelman LS, Kempf CR, et al,. 2011. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. J Cell Physiol DOI: 10.1002/jcp.22647.
25. Palomero T, Dominguez M, Ferrando AA,. 2008. The role of the PTEN/AKT pathway in NOTCH1-induced leukemia. Cell Cycle 7 (8): 965-970. (Pubitemid 351679827)
26. Peyrou M, Bourgoin L, Foti M,. 2010. PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer. Dig Dis 28 (1): 236-246.
27. Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP,. 2010. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465 (7301): 1033-1038.
28. Salvesen GS, Dixit VM,. 1997. Caspases: intracellular signaling by proteolysis. Cell 91 (4): 443-446. (Pubitemid 27508233)
29. Shukla S, Maclennan GT, Hartman DJ, Fu P, Resnick MI, Gupta S,. 2007. Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. Int J Cancer 121 (7): 1424-1432. (Pubitemid 47328700)
30. Singh RP, Agarwal R,. 2004. A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutat Res 555 (1-2): 21-32. (Pubitemid 39345395)
31. Soto C, Recoba R, Barron H, Alvarez C, Favari L,. 2003. Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol C Toxicol Pharmacol 136 (3): 205-212. (Pubitemid 37500850)
32. Varghese L, Agarwal C, Tyagi A, Singh RP, Agarwal R,. 2005. Silibinin efficacy against human hepatocellular carcinoma. Clin Cancer Res 11 (23): 8441-8448. (Pubitemid 41746959)
33. Workman P, Clarke PA, Raynaud FI, van Montfort RL,. 2010. Drugging the PI3 kinome: from chemical tools to drugs in the clinic. Cancer Res 70 (6): 2146-2157.
34. Wu KJ, Zeng J, Zhu GD, et al,. 2009. Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression. Acta Pharmacol Sin 30 (8): 1162-1168.
35. Wu YF, Fu SL, Kao CH, Yang CW, Lin CH, Hsu MT, et al,. 2008. Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice. Cancer Res 68 (6): 2033-2042.
36. Zhong X, Zhu Y, Lu Q, Zhang J, Ge Z, Zheng S,. 2006. Silymarin causes caspases activation and apoptosis in K562 leukemia cells through inactivation of Akt pathway. Toxicology 227 (3): 211-216. (Pubitemid 44402863)
37. Zhou B, Wu LJ, Tashiro S, Onodera S, Uchiumi F, Ikejima T,. 2006. Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle. Biol Pharm Bull 29 (9): 1900-1905. (Pubitemid 44338415)