Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance

PLoS Genetics

Volumn 8, Issue 1, 2012, Pages

  Alexandrov, Ilya M ^a   Ivshina, Maria ^a   Jung, Dae Young ^a   Friedline, Randall ^a   Ko, Hwi Jin ^a   Xu, Mei ^a   O'Sullivan Murphy, Bryan ^a   Bortell, Rita ^a   Huang, Yen Tsung ^b   Urano, Fumihiko ^a   Kim, Jason K ^a   Richter, Joel D ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CPEB1 PROTEIN, HUMAN; CPEB1 PROTEIN, MOUSE; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; STAT3 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; EMBRYO; GENE; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE SEQUENCE; GLUCOSE HOMEOSTASIS; HORMONE ACTION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; KNOCKOUT MOUSE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEPLETION; PROTEIN RNA BINDING; PTEN GENE; RNA ANALYSIS; RNA TRANSLATION; SIGNAL TRANSDUCTION; STAT3 GENE; TRANSLATION REGULATION; ANIMAL; CELL LINE; CYTOLOGY; FIBROBLAST; GENETICS; LIPID DIET; LIVER; METABOLISM; MOUSE MUTANT; POLYSOME; PROTEIN SYNTHESIS;

MUS;

ANIMALS; CELL LINE; DIET, HIGH-FAT; FIBROBLASTS; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, KNOCKOUT; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; PTEN PHOSPHOHYDROLASE; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 84857466289     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002457     Document Type: Article

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