Regulation of mineral metabolism by lithium

Pflugers Archiv European Journal of Physiology

Volumn 466, Issue 3, 2014, Pages 467-475

  Fakhri, Hajar ^a   Pathare, Ganesh ^a   Fajol, Abul ^a   Zhang, Bingbing ^a   Bock, Thomas ^a   Kandolf, Reinhard ^a   Schleicher, Erwin ^a   Biber, Jürg ^b   Föller, Michael ^a   Lang, Undine E ^c   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

1,25(OH)2D3; Calcium; FGF23; Klotho; Lithium; Phosphate

Indexed keywords

CALCITRIOL; CALCIUM; FIBROBLAST GROWTH FACTOR 23; GLYCOGEN SYNTHASE KINASE 3; KLOTHO PROTEIN; LITHIUM; PHOSPHATE; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CONTROLLED STUDY; DOWN REGULATION; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; METABOLIC REGULATION; MINERAL METABOLISM; MOUSE; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHOSPHATE EXCRETION; PHOTOMETRY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; URINARY EXCRETION; VASOPRESSIN BLOOD LEVEL; VITAMIN BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; CALCITRIOL; CALCIUM; FEMALE; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; KIDNEY; LITHIUM; MICE; MICE, INBRED C57BL; PHOSPHATES;

EID: 84896738682     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-013-1340-y     Document Type: Article

References (88)

1. Albert U, De Cori D, Aguglia A, Barbaro F, Lanfranco F, Bogetto F, Maina G (2013) Lithium-associated hyperparathyroidism and hypercalcemia: a case-control cross-sectional study. J Affect Disord. doi: 10.1016/j.jad.2013.06. 046
2. Bai X, Dinghong Q, Miao D, Goltzman D, Karaplis AC (2009) Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype. Am J Physiol Endocrinol Metab 296(1):E79-E88
3. Bai X, Miao D, Li J, Goltzman D, Karaplis AC (2004) Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 145(11):5269-5279
4. Bai XY, Miao D, Goltzman D, Karaplis AC (2003) The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency. J Biol Chem 278(11):9843-9849
5. Bernheim J, Benchetrit S (2011) The potential roles of FGF23 and Klotho in the prognosis of renal and cardiovascular diseases. Nephrol Dial Transplant 26(8):2433-2438
6. Bhat RV, Budd Haeberlein SL, Avila J (2004) Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 89(6):1313-1317
7. Birnbaum J, Klandorf H, Giuliano A, Van Herle A (1988) Lithium stimulates the release of human parathyroid hormone in vitro. J Clinical Endocrinol Metab 66(6):1187-1191
8. Bockenhauer D, Bichet DG (2013) Inherited secondary nephrogenic diabetes insipidus: concentrating on humans. Am J Physiol Renal Physiol 304(8):F1037-F1042
9. Broome JT, Solorzano CC (2011) Lithium use and primary hyperparathyroidism. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol 17(Suppl 1):31-35. doi: 10.4158/EP10273.RA
10. Brown AJ, Finch J, Slatopolsky E (2002) Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport. J Lab Clin Med 139(5):279-284
11. Carpinelli MR, Wise AK, Burt RA (2011) Vitamin D-deficient diet rescues hearing loss in Klotho mice. Hear Res 275(1-2):105-109
12. Cross HR, Radda GK, Clarke K (1995) The role of Na+/K + ATPase activity during low flow ischemia in preventing myocardial injury: a 31P, 23Na, and 87Rb NMR spectroscopic study. Magn Reson Med 34(5):673-685
13. Custer M, Lotscher M, Biber J, Murer H, Kaissling B (1994) Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am J Physiol 266(5 Pt 2):F767-F774
14. Dermaku-Sopjani M, Sopjani M, Saxena A, Shojaiefard M, Bogatikov E, Alesutan I, Eichenmuller M, Lang F (2011) Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. Cell Physiol Biochem 28(2):251-258
15. Desjardins L, Liabeuf S, Renard C, Lenglet A, Lemke HD, Choukroun G, Drueke TB, Massy ZA, Group. EUTEW (2012) FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages. Osteoporos Int 23(7):2017-2025
16. Eldar-Finkelman H (2002) Glycogen synthase kinase 3: an emerging therapeutic target. Trends Mol Med 8(3):126-132
17. Fukuchi Y (2009) The aging lung and chronic obstructive pulmonary disease: similarity and difference. Proc Am Thorac Soc 6(7):570-572
18. 3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4. Am J Physiol Renal Physiol 301(2):F371-F377
19. George B, Vollenbroker B, Saleem MA, Huber TB, Pavenstadt H, Weide T (2011) GSK3beta inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility. Am J Physiol Renal Physiol 300(5):F1152-F1162
20. Giachelli CM (2003) Vascular calcification: in vitro evidence for the role of inorganic phosphate. J Am Soc Nephrol 14(9 Suppl 4):S300-S304
21. Grunfeld JP, Rossier BC (2009) Lithium nephrotoxicity revisited. Nat Rev Nephrol 5(5):270-276. doi: 10.1038/nrneph.2009.43
22. Hernandez F, Lucas JJ, Avila J (2013) GSK3 and tau: two convergence points in Alzheimer's disease. J Alzheimers Dis 33(Suppl 1):S141-S144
23. Hori M, Shimizu Y, Fukumoto S (2011) Minireview: fibroblast growth factor 23 in phosphate homeostasis and bone metabolism. Endocrinology 152(1):4-10
24. Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, Lanske B, Razzaque MS, Rosenblatt KP, Baum MG, Moe OW (2010) Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 24(9):3438-3450
25. Hu MC, Shiizaki K, Kuro O, Moe OW (2013) Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol 75:503-533
26. Inoue Y, Segawa H, Kaneko I, Yamanaka S, Kusano K, Kawakami E, Furutani J, Ito M, Kuwahata M, Saito H, Fukushima N, Kato S, Kanayama HO, Miyamoto K (2005) Role of the vitamin D receptor in FGF23 action on phosphate metabolism. Biochem J 390(Pt 1):325-331
27. Jope RS (2011) Glycogen synthase kinase-3 in the etiology and treatment of mood disorders. Front Mol Neurosci 4:16
28. Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, Shirai Y, Horie K, Saito N, Takeda J, Hara H (2010) Diacylglycerol kinase beta knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS One 5(10):e13447
29. Kempe DS, Ackermann TF, Fischer SS, Koka S, Boini KM, Mahmud H, Foller M, Rosenblatt KP, Kuro O, Lang F (2009) Accelerated suicidal erythrocyte death in Klotho-deficient mice. Pflugers Arch 458(3):503-512
30. Khairallah W, Fawaz A, Brown EM, El-Hajj Fuleihan G (2007) Hypercalcemia and diabetes insipidus in a patient previously treated with lithium. Nat Clin Pract Nephrol 3(7):397-404. doi: 10.1038/ncpneph0525
31. Kishore BK, Ecelbarger CM (2013) Lithium: a versatile tool to understand renal physiology. Am J Physiol Renal Physiol 304(9):F1139-F1149
32. Kjaersgaard G, Madsen K, Marcussen N, Christensen S, Walter S, Jensen BL (2012) Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase-3beta-positive epithelium. Am J Physiol Renal Physiol 302(4):F455-F465
33. Kolek OI, Hines ER, Jones MD, LeSueur LK, Lipko MA, Kiela PR, Collins JF, Haussler MR, Ghishan FK (2005) 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 289(6):G1036-G1042. doi: 10.1152/ajpgi.00243.2005
34. Komaba H, Fukagawa M (2012) The role of FGF23 in CKD-with or without Klotho. Nat Rev Nephrol 8(8):484-490
35. Kosakai A, Ito D, Nihei Y, Yamashita S, Okada Y, Takahashi K, Suzuki N (2011) Degeneration of mesencephalic dopaminergic neurons in Klotho mouse related to vitamin D exposure. Brain Res 1382:109-117
36. Kuro-o M (2010) Klotho. Pflugers Arch 459(2):333-343
37. Kuro-o M (2010) Overview of the FGF23-Klotho axis. Pediatr Nephrol 25(4):583-590
38. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390(6655):45-51
39. Kuro O (2012) Klotho and betaKlotho. Adv Exp Med Biol 728:25-40
40. Lally J, Lee B, McDonald C (2013) Prevalence of hypercalcemia in patients on maintenance lithium therapy monitored in primary care. Irish Med J 106(1):15-17
41. Lang F, Ritz E, Voelkl J, Alesutan I (2013) Vascular calcification - is aldosterone a culprit? Nephrol Dial Transplant 28(5):1080-1084
42. Larsson T, Marsell R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Juppner H, Jonsson KB (2003) Transgenic mice expressing fibroblast growth factor 23 under the control of the a1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostatis. Endocrinology 145(3087):3094
43. Lee YJ, Lee JE, Choi HJ, Lim JS, Jung HJ, Baek MC, Frokiaer J, Nielsen S, Kwon TH (2011) E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal. Am J Physiol Renal Physiol 301(4):F883-F896
44. Lehmann SW, Lee J (2013) Lithium-associated hypercalcemia and hyperparathyroidism in the elderly: what do we know? J Affect Disord 146(2):151-157. doi: 10.1016/j.jad.2012.08.028
45. Lim K, Lu TS, Molostvov G, Lee C, Lam FT, Zehnder D, Hsiao LL (2012) Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation 125(18):2243-2255
46. London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H (2003) Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 18(9):1731-1740
47. Lu Y, Feng JQ (2011) FGF23 in skeletal modeling and remodeling. Curr Osteoporos Rep 9(2):103-108
48. Lumachi F, Cappelletti P, Tozzoli R, Basso SM, Luisetto G, Camozzi V (2012) Diagnosis of alterations of serum calcium metabolism. Med Chem 8(4):551-555
49. Mackenzie NC, MacRae VE (2011) The role of cellular senescence during vascular calcification: a key paradigm in aging research. Curr Aging Sci 4(2):128-136
50. Maltese G, Karalliedde J (2012) The putative role of the antiaging protein Klotho in cardiovascular and renal disease. Int J Hypertens 2012:757469
51. Marsell R, Jonsson KB (2010) The phosphate regulating hormone fibroblast growth factor-23. Acta Physiol (Oxf) 200(2):97-106
52. Martinez A, Castro A, Dorronsoro I, Alonso M (2002) Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med Res Rev 22(4):373-384
53. Masuyama R, Stockmans I, Torrekens S, Van Looveren R, Maes C, Carmeliet P, Bouillon R, Carmeliet G (2006) Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest 116(12):3150-3159
54. Miyamoto K, Segawa H, Ito M, Kuwahata M (2004) Physiological regulation of renal sodium-dependent phosphate cotransporters. Jpn J Physiol 54(2):93-102
55. Murer H, Hernando N, Forster I, Biber J (2000) Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol Rev 80(4):1373-1409
56. Nikolov IG, Mozar A, Drueke TB, Massy ZA (2009) Impact of disturbances of calcium and phosphate metabolism on vascular calcification and clinical outcomes in patients with chronic kidney disease. Blood Purif 27(4):350-359
57. Ohnishi M, Razzaque MS (2010) Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 24(9):3562-3571
58. Pathare G, Foller M, Daryadel A, Mutig K, Bogatikov E, Fajol A, Almilaji A, Michael D, Stange G, Voelkl J, Wagner CA, Bachmann S, Lang F (2012) OSR1-sensitive renal tubular phosphate reabsorption. Kidney Blood Press Res 36(1):149-161
59. Pathare G, Foller M, Michael D, Walker B, Hierlmeier M, Mannheim JG, Pichler BJ, Lang F (2012) Enhanced FGF23 serum concentrations and phosphaturia in gene-targeted mice expressing WNK-resistant SPAK. Kidney Blood Press Res 36(1):355-364
60. Rao R (2012) Glycogen synthase kinase-3 regulation of urinary concentrating ability. Curr Opin Nephrol Hypertens 21(5):541-546
61. Rodriguez M, Martinez-Moreno JM, Rodriguez-Ortiz ME, Munoz-Castaneda JR, Almaden Y (2011) Vitamin D and vascular calcification in chronic kidney disease. Kidney Blood Press Res 34(4):261-268
62. Saito H, Kusano K, Kinosaki M, Ito H, Hirata M, Segawa H, Miyamoto K, Fukushima N (2003) Human fibroblast growth factor-23 mutants suppress Na + -dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. J Biol Chem 278(4):2206-2211
63. Saito Y, Nakamura T, Ohyama Y, Suzuki T, Iida A, Shiraki-Iida T, Nabeshima Y, Kurabayashi M, Nagai R (2000) In vivo Klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun 276(2):767-772
64. Sakoda H, Gotoh Y, Katagiri H, Kurokawa M, Ono H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Fukushima Y, Abe M, Shojima N, Kikuchi M, Oka Y, Hirai H, Asano T (2003) Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 278(28):25802-25807
65. Sanches TR, Volpini RA, Massola Shimizu MH, Braganca AC, Oshiro-Monreal F, Seguro AC, Andrade L (2012) Sildenafil reduces polyuria in rats with lithium-induced NDI. Am J Physiol Renal Physiol 302(1):F216-F225
66. Sandulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, Mack A, Friedrich B, Vallon V, Wulff P, Kuhl D, Palmada M, Lang F (2006) Renal Ca2+ handling in sgk1 knockout mice. Pflugers Arch 452(4):444-452. doi: 10.1007/s00424-005-0021-x
67. Schoppet M, Hofbauer LC, Brinskelle-Schmal N, Varennes A, Goudable J, Richard M, Hawa G, Chapurlat R, Szulc P (2012) Serum level of the phosphaturic factor FGF23 is associated with abdominal aortic calcification in men: the STRAMBO study. J Clin Endocrinol Metab 97(4):E575-E583
68. Segawa H, Kaneko I, Yamanaka S, Ito M, Kuwahata M, Inoue Y, Kato S, Miyamoto K (2004) Intestinal Na-P(i) cotransporter adaptation to dietary P(i) content in vitamin D receptor null mice. Am J Physiol Renal Physiol 287(1):F39-F47
69. Segawa H, Kawakami E, Kaneko I, Kuwahata M, Ito M, Kusano K, Saito H, Fukushima N, Miyamoto K (2003) Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter. Pflugers Arch 446(5):585-592
70. Shaw M, Cohen P, Alessi DR (1997) Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett 416(3):307-311
71. Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S, Yamashita T (2004) FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19(3):429-435
72. Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, Fukumoto S, Tomizuka K, Yamashita T (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113(4):561-568
73. Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, Takeda S, Takeuchi Y, Fujita T, Fukumoto S, Yamashita T (2001) Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A 98(11):6500-6505
74. Shimada T, Takeshita Y, Murohara T, Sasaki K, Egami K, Shintani S, Katsuda Y, Ikeda H, Nabeshima Y, Imaizumi T (2004) Angiogenesis and vasculogenesis are impaired in the precocious-aging Klotho mouse. Circulation 110(9):1148-1155
75. Shimada T, Yamazaki Y, Takahashi M, Hasegawa H, Urakawa I, Oshima T, Ono K, Kakitani M, Tomizuka K, Fujita T, Fukumoto S, Yamashita T (2005) Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am J Physiol Renal Physiol 289(5):F1088-F1095
76. Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Juppner H, Lanske B (2004) Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 23(7):421-432
77. Sugawara M, Hashimoto K, Ota Z (1988) Involvement of prostaglandin E2, cAMP, and vasopressin in lithium-induced polyuria. Am J Physiol 254(6 Pt 2):R863-R869
78. Takenaka T, Watanabe Y, Inoue T, Miyazaki T, Suzuki H (2013) Fibroblast growth factor 23 enhances renal Klotho abundance. Pflugers Arch 465(7):935-943
79. Takeshita K, Fujimori T, Kurotaki Y, Honjo H, Tsujikawa H, Yasui K, Lee JK, Kamiya K, Kitaichi K, Yamamoto K, Ito M, Kondo T, Iino S, Inden Y, Hirai M, Murohara T, Kodama I, Nabeshima Y (2004) Sinoatrial node dysfunction and early unexpected death of mice with a defect of Klotho gene expression. Circulation 109(14):1776-1782
80. Tang C, Pathare G, Michael D, Fajol A, Eichenmuller M, Lang F (2011) Downregulation of Klotho expression by dehydration. Am J Physiol Renal Physiol 301(4):F745-F750
81. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G (2005) Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 112(17):2627-2633
82. Torres PU, Prie D, Molina-Bletry V, Beck L, Silve C, Friedlander G (2007) Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 71(8):730-737
83. Tuohimaa P (2009) Vitamin D and aging. J Steroid Biochem Mol Biol 114(1-2):78-84
84. Tyber MA (1974) Treatment of the painful shoulder syndrome with amitriptyline and lithium carbonate. Can Med Assoc J 111(2):137-140
85. Unsal A, Kose BS, Koc Y, Basturk T, Sakaci T, Ahbap E, Sinangil A (2012) Relationship of fibroblast growth factor 23 with left ventricle mass index and coronary calcification in chronic renal disease. Kidney Blood Press Res 36(1):55-64
86. Wyatt AW, Hussain A, Amann K, Klingel K, Kandolf R, Artunc F, Grahammer F, Huang DY, Vallon V, Kuhl D, Lang F (2006) DOCA-induced phosphorylation of glycogen synthase kinase 3beta. Cell Physiol Biochem 17(3-4):137-144
87. Yoshida T, Fujimori T, Nabeshima Y (2002) Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous Klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 143(2):683-689
88. Zhang Y, Pop IL, Carlson NG, Kishore BK (2012) Genetic deletion of the P2Y2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE2 signaling. Am J Physiol Renal Physiol 302(1):F70-F77