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Volumn 10, Issue 3, 2013, Pages 93-101

Mesenchymal stem cell-derived secretome and microvesicles as a cell-free therapeutics for neurodegenerative disorders

Author keywords

Mesenchymal stem cells; Microvesicles; Neurodegenerative disorders; Secretome

Indexed keywords

DISEASE CONTROL; FLOWCHARTING; NEURODEGENERATIVE DISEASES; STEM CELLS; TISSUE; TISSUE REGENERATION;

EID: 84896735159     PISSN: 17382696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13770-013-0010-7     Document Type: Article
Times cited : (95)

References (101)
  • 1
    • 0016269155 scopus 로고
    • Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues: Cloning in vitro and retransplantation in vivo
    • AJ Friedenstein, RK Chailakhyan, NV Latsinik, et al., Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues: cloning in vitro and retransplantation in vivo, Transplantation, 17, 331 (1974).
    • (1974) Transplantation , vol.17 , pp. 331
    • Friedenstein, A.J.1    Chailakhyan, R.K.2    Latsinik, N.V.3
  • 2
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • MF Pittenger, AM Mackay, SC Beck, et al., Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143 (1999).
    • (1999) Science , vol.284 , pp. 143
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 3
    • 41549139755 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Revisiting history, concepts, and assays
    • P Bianco, PG Robey, PJ Simmons, Mesenchymal stem cells: revisiting history, concepts, and assays, Cell Stem Cell, 2, 313 (2008).
    • (2008) Cell Stem Cell , vol.2 , pp. 313
    • Bianco, P.1    Robey, P.G.2    Simmons, P.J.3
  • 4
    • 0036106054 scopus 로고    scopus 로고
    • Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells
    • RE Schwartz, M Reyes, L Koodie, et al., Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells, J Clin Invest 109, 1291 (2002).
    • (2002) J Clin Invest , vol.109 , pp. 1291
    • Schwartz, R.E.1    Reyes, M.2    Koodie, L.3
  • 5
    • 0034537437 scopus 로고    scopus 로고
    • Adult bone marrow stromal cells differentiate into neural cells in vitro
    • J Sanchez-Ramos, S Song, F Cardozo-Pelaez, et al., Adult bone marrow stromal cells differentiate into neural cells in vitro, Exp Neurol, 164, 247 (2000).
    • (2000) Exp Neurol , vol.164 , pp. 247
    • Sanchez-Ramos, J.1    Song, S.2    Cardozo-Pelaez, F.3
  • 6
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Y Jiang, BN Jahagirdar, RL Reinhardt, et al., Pluripotency of mesenchymal stem cells derived from adult marrow, Nature, 418, 41 (2002).
    • (2002) Nature , vol.418 , pp. 41
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 7
    • 27944435821 scopus 로고    scopus 로고
    • Clarification of the nomenclature for msc: The international society for cellular therapy position statement
    • EM Horwitz, K Le Blanc, M Dominici, et al., Clarification of the nomenclature for MSC: the international society for cellular therapy position statement, Cytotherapy, 7, 393 (2005).
    • (2005) Cytotherapy , vol.7 , pp. 393
    • Horwitz, E.M.1    Le Blanc, K.2    Dominici, M.3
  • 8
    • 35348921682 scopus 로고    scopus 로고
    • Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    • B Sacchetti, A Funari, S Michienzi, et al., Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment, Cell, 131, 324 (2007).
    • (2007) Cell , vol.131 , pp. 324
    • Sacchetti, B.1    Funari, A.2    Michienzi, S.3
  • 9
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement
    • M Dominici, K Le Blanc, I Mueller, et al., Minimal criteria for defining multipotent mesenchymal stromal cells. the international society for cellular therapy position statement, Cytotherapy, 8, 315 (2006).
    • (2006) Cytotherapy , vol.8 , pp. 315
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 10
    • 59749100262 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells: Isolation, expansion, characterization, viral transduction, and production of conditioned medium
    • M Gnecchi, LG Melo, Bone marrow-derived mesenchymal stem cells: isolation, expansion, characterization, viral transduction, and production of conditioned medium, Methods Mol Biol, 482, 281 (2009).
    • (2009) Methods Mol Biol , vol.482 , pp. 281
    • Gnecchi, M.1    Melo, L.G.2
  • 11
    • 84863066311 scopus 로고    scopus 로고
    • Isolation of mesenchymal stem cells from the mononuclear cells remaining in the bone marrow processing kit
    • S Kim, JS Heo, HS Kim, et al., Isolation of mesenchymal stem cells from the mononuclear cells remaining in the bone marrow processing kit, Korean J Blood Transfusion, 21, 280 (2010).
    • (2010) Korean J Blood Transfusion , vol.21 , pp. 280
    • Kim, S.1    Heo, J.S.2    Kim, H.S.3
  • 12
    • 33645322638 scopus 로고    scopus 로고
    • The heterogeneity of human mesenchymal stem cell preparations- evidence from simultaneous analysis of proteomes and transcriptomes
    • W Wagner, REJ Feldmann, A Seckinger, et al., The heterogeneity of human mesenchymal stem cell preparations- evidence from simultaneous analysis of proteomes and transcriptomes, Exp Hematol, 34, 536 (2006).
    • (2006) Exp Hematol , vol.34 , pp. 536
    • Wagner, W.1    Rej, F.2    Seckinger, A.3
  • 13
    • 34247532764 scopus 로고    scopus 로고
    • Clonal isolation and characterization of bone marrow stromal cells from patients with osteoarthritis
    • S Mareddy, R Crawford, G Brooke, et al., Clonal isolation and characterization of bone marrow stromal cells from patients with osteoarthritis, Tissue Eng, 13, 819 (2007).
    • (2007) Tissue Eng , vol.13 , pp. 819
    • Mareddy, S.1    Crawford, R.2    Brooke, G.3
  • 14
    • 79952109021 scopus 로고    scopus 로고
    • Clonal characterization of bone marrow derived stem cells and their application for bone regeneration
    • Y Xiao, S Mareddy, R Crawford, Clonal characterization of bone marrow derived stem cells and their application for bone regeneration, Int J Oral Sci, 2, 127 (2010).
    • (2010) Int J Oral Sci , vol.2 , pp. 127
    • Xiao, Y.1    Mareddy, S.2    Crawford, R.3
  • 15
    • 84865384024 scopus 로고    scopus 로고
    • Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived msc subsets
    • K Sivasubramaniyan, D Lehnen, R Ghazanfari, et al., Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets, Ann NY Acad Sci, 1266, 94 (2012).
    • (2012) Ann NY Acad Sci , vol.1266 , pp. 94
    • Sivasubramaniyan, K.1    Lehnen, D.2    Ghazanfari, R.3
  • 16
    • 0031954963 scopus 로고    scopus 로고
    • Mesenchymal stem cell surface antigen sb-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation
    • SP Bruder, NS Ricalton, RE Boynton, et al., Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation, J Bone Mineral Res, 13, 655 (1998).
    • (1998) J Bone Mineral Res , vol.13 , pp. 655
    • Bruder, S.P.1    Ricalton, N.S.2    Boynton, R.E.3
  • 17
    • 0034737742 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase
    • RK Jaiswal, N Jaiswal, SP Bruder, et al., Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase, J Biol Chem, 275, 9645 (2000).
    • (2000) J Biol Chem , vol.275 , pp. 9645
    • Jaiswal, R.K.1    Jaiswal, N.2    Bruder, S.P.3
  • 18
    • 0035882056 scopus 로고    scopus 로고
    • Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation- dependent gene expression of matrix components
    • F Barry, RE Boynton, B Liu, et al., Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation- dependent gene expression of matrix components, Exp Cell Res, 268, 189 (2001).
    • (2001) Exp Cell Res , vol.268 , pp. 189
    • Barry, F.1    Boynton, R.E.2    Liu, B.3
  • 19
    • 0031909665 scopus 로고    scopus 로고
    • Role of morphogenetic proteins in skeletal tissue engineering and regeneration
    • AH Reddi, Role of morphogenetic proteins in skeletal tissue engineering and regeneration, Nature Biotech, 16, 247 (1998).
    • (1998) Nature Biotech , vol.16 , pp. 247
    • Reddi, A.H.1
  • 20
    • 25844509347 scopus 로고    scopus 로고
    • Canonical wnt signaling promotes osteogenesis by directly stimulating runx2 gene expression
    • T Gaur, CJ Lengner, H Hovhannisyan, et al., Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression, J Biol Chem, 280, 33132 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 33132
    • Gaur, T.1    Lengner, C.J.2    Hovhannisyan, H.3
  • 21
    • 77957800393 scopus 로고    scopus 로고
    • Mechanical stimulation of mesenchymal stem cells for tissue engineering
    • JH Kim, CS Cho, YH Choung, et al., Mechanical stimulation of mesenchymal stem cells for tissue engineering, Tissue Eng Reg Med, 6, 199 (2009).
    • (2009) Tissue Eng Reg Med , vol.6 , pp. 199
    • Kim, J.H.1    Cho, C.S.2    Choung, Y.H.3
  • 22
    • 0033106384 scopus 로고    scopus 로고
    • Cardiomyocytes can be generated from marrow stromal cells in vitro
    • S Makino, K Fukuda, S Miyoshi, et al., Cardiomyocytes can be generated from marrow stromal cells in vitro, J Clin Invest, 103, 697 (1999).
    • (1999) J Clin Invest , vol.103 , pp. 697
    • Makino, S.1    Fukuda, K.2    Miyoshi, S.3
  • 23
    • 0032489651 scopus 로고    scopus 로고
    • Muscle regeneration by bone marrow-derived myogenic progenitors
    • G Ferrari, G Cusella-De Angelis, M Coletta, et al., Muscle regeneration by bone marrow-derived myogenic progenitors, Science, 279, 1528 (1998).
    • (1998) Science , vol.279 , pp. 1528
    • Ferrari, G.1    Cusella-De Angelis, G.2    Coletta, M.3
  • 24
    • 0038755063 scopus 로고    scopus 로고
    • Isolation of bone marrow stromal cell-derived smooth muscle cells by a human sm22alpha promoter: In vitro differentiation of putative smooth muscle progenitor cells of bone marrow
    • Y Kashiwakura, Y Katoh, K Tamayose, et al., Isolation of bone marrow stromal cell-derived smooth muscle cells by a human SM22alpha promoter: in vitro differentiation of putative smooth muscle progenitor cells of bone marrow, Circulation, 107, 2078 (2003).
    • (2003) Circulation , vol.107 , pp. 2078
    • Kashiwakura, Y.1    Katoh, Y.2    Tamayose, K.3
  • 25
    • 0032874061 scopus 로고    scopus 로고
    • Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains
    • GC Kopen, DJ Prockop, DG Phinney, Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains, Proc Natl Acad Sci USA, 96, 10711 (1999).
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10711
    • Kopen, G.C.1    Prockop, D.J.2    Phinney, D.G.3
  • 26
    • 0035881367 scopus 로고    scopus 로고
    • Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats
    • J Chen, Y Li, L Wang, et al., Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats, J Neurol Sci, 189, 49 (2001).
    • (2001) J Neurol Sci , vol.189 , pp. 49
    • Chen, J.1    Li, Y.2    Wang, L.3
  • 27
    • 0033553591 scopus 로고    scopus 로고
    • Bone marrow as a potential source of hepatic oval cells
    • BE Petersen, WC Bowen, KD Patrene, et al., Bone marrow as a potential source of hepatic oval cells, Science, 284, 1168 (1999).
    • (1999) Science , vol.284 , pp. 1168
    • Petersen, B.E.1    Bowen, W.C.2    Patrene, K.D.3
  • 28
    • 0033694301 scopus 로고    scopus 로고
    • Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    • E Lagasse, H Connors, M Al-Dhalimy, et al., Purified hematopoietic stem cells can differentiate into hepatocytes in vivo, Nature Med, 6, 1229 (2000).
    • (2000) Nature Med , vol.6 , pp. 1229
    • Lagasse, E.1    Connors, H.2    Al-Dhalimy, M.3
  • 29
    • 33646566806 scopus 로고    scopus 로고
    • Human mesenchymal stem cells express neural genes, suggesting a neural predisposition
    • NR Blondheim, YS Levy, T Ben-Zur, et al., Human mesenchymal stem cells express neural genes, suggesting a neural predisposition, Stem Cells Dev, 15, 141 (2006).
    • (2006) Stem Cells Dev , vol.15 , pp. 141
    • Blondheim, N.R.1    Levy, Y.S.2    Ben-Zur, T.3
  • 30
    • 0034663515 scopus 로고    scopus 로고
    • Adult rat and human bone marrow stromal cells differentiate into neurons
    • D Woodbury, EJ Schwarz, DJ Prockop, et al., Adult rat and human bone marrow stromal cells differentiate into neurons, J Neurosci Res, 61, 364 (2000).
    • (2000) J Neurosci Res , vol.61 , pp. 364
    • Woodbury, D.1    Schwarz, E.J.2    Prockop, D.J.3
  • 31
    • 0242637612 scopus 로고    scopus 로고
    • Induction of neuronspecific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells
    • YS Levy, D Merims, H Panet, et al., Induction of neuronspecific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells, J Mol Neurosci, 21, 121 (2003).
    • (2003) J Mol Neurosci , vol.21 , pp. 121
    • Levy, Y.S.1    Merims, D.2    Panet, H.3
  • 32
    • 58149170639 scopus 로고    scopus 로고
    • Long-term serial passage and neuronal differentiation capability of human bone marrow mesenchymal stem cells
    • ML Khoo, B Shen, H Tao, et al., Long-term serial passage and neuronal differentiation capability of human bone marrow mesenchymal stem cells, Stem Cells Dev, 17, 883 (2008).
    • (2008) Stem Cells Dev , vol.17 , pp. 883
    • Khoo, M.L.1    Shen, B.2    Tao, H.3
  • 33
    • 0037418179 scopus 로고    scopus 로고
    • Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma
    • JL Spees, SD Olson, J Ylostalo, et al., Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma, Proc Natl Acad Sci USA, 100, 2397 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2397
    • Spees, J.L.1    Olson, S.D.2    Ylostalo, J.3
  • 34
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem/ multipotent stromal cells: The state of transdifferentiation and modes of tissue repair-current views
    • DG Phinney, DJ Prockop, Concise review: mesenchymal stem/ multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views, Stem Cells, 25, 2896 (2007).
    • (2007) Stem Cells , vol.25 , pp. 2896
    • Phinney, D.G.1    Prockop, D.J.2
  • 35
    • 79952905311 scopus 로고    scopus 로고
    • In vivo hepatic differentiation potential of human cord blood-derived mesenchymal stem cells
    • S Kim, HS Kim, E Lee, et al., In vivo hepatic differentiation potential of human cord blood-derived mesenchymal stem cells, Int J Mol Med, 27, 701 (2011).
    • (2011) Int J Mol Med , vol.27 , pp. 701
    • Kim, S.1    Kim, H.S.2    Lee, E.3
  • 36
    • 0042887242 scopus 로고    scopus 로고
    • Regulation of neural markers nestin and gfap expression by cultivated bone marrow stromal cells
    • S Wislet-Gendebien, P Leprince, G Moonen, et al., Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells, J Cell Sci, 116, 3295 (2003).
    • (2003) J Cell Sci , vol.116 , pp. 3295
    • Wislet-Gendebien, S.1    Leprince, P.2    Moonen, G.3
  • 37
    • 18144380142 scopus 로고    scopus 로고
    • Bone marrowderived mesenchymal stem cells already express specific neural proteins before any differentiation
    • T Tondreau, L Lagneaux, M Dejeneffe, et al., Bone marrowderived mesenchymal stem cells already express specific neural proteins before any differentiation, Differentiation, 72, 319 (2004).
    • (2004) Differentiation , vol.72 , pp. 319
    • Tondreau, T.1    Lagneaux, L.2    Dejeneffe, M.3
  • 38
    • 33745499805 scopus 로고    scopus 로고
    • Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation
    • J Deng, BE Petersen, DA Steindler, et al., Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation, Stem Cells, 24, 1054 (2006).
    • (2006) Stem Cells , vol.24 , pp. 1054
    • Deng, J.1    Petersen, B.E.2    Steindler, D.A.3
  • 39
    • 0036118625 scopus 로고    scopus 로고
    • Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats
    • LR Zhao, WM Duan, M Reyes, et al., Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats, Exp Neurol, 174, 11 (2002).
    • (2002) Exp Neurol , vol.174 , pp. 11
    • Zhao, L.R.1    Duan, W.M.2    Reyes, M.3
  • 40
    • 30344440721 scopus 로고    scopus 로고
    • Transdifferentiation of mesenchymal stem cells into schwann cell-like myelinating cells
    • G Keilhoff, A Goihl, K Langnäse, et al., Transdifferentiation of mesenchymal stem cells into Schwann cell-like myelinating cells, Eur J Cell Biol, 85, 11 (2006).
    • (2006) Eur J Cell Biol , vol.85 , pp. 11
    • Keilhoff, G.1    Goihl, A.2    Langnäse, K.3
  • 41
    • 47249119239 scopus 로고    scopus 로고
    • Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of parkinson's disease
    • YS Levy, M Bahat-Stroomza, R Barzilay, et al., Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease, Cytotherapy, 10, 340 (2008).
    • (2008) Cytotherapy , vol.10 , pp. 340
    • Levy, Y.S.1    Bahat-Stroomza, M.2    Barzilay, R.3
  • 42
    • 65949121841 scopus 로고    scopus 로고
    • Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype
    • NL Kennea, SN Waddington, J Chan, et al., Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype, Cell Cycle, 8, 1069 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 1069
    • Kennea, N.L.1    Waddington, S.N.2    Chan, J.3
  • 43
    • 3042801100 scopus 로고    scopus 로고
    • Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: Disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype
    • B Neuhuber, G Gallo, L Howard, et al., Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype, J Neurosci Res, 77, 192 (2004).
    • (2004) J Neurosci Res , vol.77 , pp. 192
    • Neuhuber, B.1    Gallo, G.2    Howard, L.3
  • 44
    • 33846639224 scopus 로고    scopus 로고
    • Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment
    • Y Iso, JL Spees, C Serrano, et al., Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment, Biochem Biophys Res Commun, 354, 700 (2007).
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 700
    • Iso, Y.1    Spees, J.L.2    Serrano, C.3
  • 45
    • 84862835586 scopus 로고    scopus 로고
    • Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation
    • L von Bahr, I Batsis, G Moll, et al., Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation, Stem Cells, 30, 1575 (2012).
    • (2012) Stem Cells , vol.30 , pp. 1575
    • Von Bahr, L.1    Batsis, I.2    Moll, G.3
  • 46
    • 26244441779 scopus 로고    scopus 로고
    • Neurogenic potential of human mesenchymal stem cells revisited: Analysis by immunostaining, time-lapse video and microarray
    • N Bertani, P Malatesta, G Volpi, et al., Neurogenic potential of human mesenchymal stem cells revisited: analysis by immunostaining, time-lapse video and microarray, J Cell Sci, 118, 3925 (2005).
    • (2005) J Cell Sci , vol.118 , pp. 3925
    • Bertani, N.1    Malatesta, P.2    Volpi, G.3
  • 47
    • 33749067408 scopus 로고    scopus 로고
    • Analysis of neuron-like differentiation of human bone marrow mesenchymal stem cells
    • CB Choi, YK Cho, KV Prakash, et al., Analysis of neuron-like differentiation of human bone marrow mesenchymal stem cells, Biochem Biophys Res Commun, 350, 138 (2006).
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 138
    • Choi, C.B.1    Cho, Y.K.2    Prakash, K.V.3
  • 48
    • 42949171536 scopus 로고    scopus 로고
    • Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells
    • T Tondreau, M Dejeneffe, N Meuleman, et al., Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells, BMC Genomics, 9, 166 (2008).
    • (2008) BMC Genomics , vol.9 , pp. 166
    • Tondreau, T.1    Dejeneffe, M.2    Meuleman, N.3
  • 49
    • 13544268736 scopus 로고    scopus 로고
    • Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
    • Y Li, J Chen, CL Zhang, et al., Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells, Glia, 49, 407 (2005).
    • (2005) Glia , vol.49 , pp. 407
    • Li, Y.1    Chen, J.2    Zhang, C.L.3
  • 50
    • 77949576510 scopus 로고    scopus 로고
    • Cell therapy for neonatal hypoxicischemic encephalopathy
    • PM Pimentel-Coelho, R Mendez-Otero, Cell therapy for neonatal hypoxicischemic encephalopathy, Stem Cells Dev, 19, 299 (2010).
    • (2010) Stem Cells Dev , vol.19 , pp. 299
    • Pimentel-Coelho, P.M.1    Mendez-Otero, R.2
  • 51
    • 71749083461 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against mptp toxicity in the substantia nigra in a model of parkinson's disease
    • YX Chao, BP He, SS Tay, Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease, J Neuroimmunol, 216, 39 (2009).
    • (2009) J Neuroimmunol , vol.216 , pp. 39
    • Chao, Y.X.1    He B, P.2    Tay, S.S.3
  • 52
    • 58149333136 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells reduce brain amyloid-beta deposition and accelerate the activation of microglia in an acutely induced alzheimer's disease mouse model
    • JK Lee, HK Jin, JS Bae, Bone marrow-derived mesenchymal stem cells reduce brain amyloid-beta deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model, Neurosci Lett, 450, 136 (2009).
    • (2009) Neurosci Lett , vol.450 , pp. 136
    • Lee, J.K.1    Jin, H.K.2    Bae, J.S.3
  • 53
    • 54949145003 scopus 로고    scopus 로고
    • Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxicischemic rats
    • T Yasuhara, K Hara, M Maki, et al., Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxicischemic rats, J Cereb Blood Flow Metab, 28, 1804 (2008).
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1804
    • Yasuhara, T.1    Hara, K.2    Maki, M.3
  • 54
    • 78149244306 scopus 로고    scopus 로고
    • Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: A longitudinal imaging study
    • JS Jackson, JP Golding, C Chapon, et al., Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study, Stem Cell Res Ther, 1, 17 (2010).
    • (2010) Stem Cell Res Ther , vol.1 , pp. 17
    • Jackson, J.S.1    Golding, J.P.2    Chapon, C.3
  • 55
    • 84866862490 scopus 로고    scopus 로고
    • The preventive and therapeutic effects of intravenous human adipose-derived stem cells in alzheimer's disease mice
    • S Kim, KA Chang, J Kim, et al., The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice, PLoS One, 7, e45757 (2012).
    • (2012) PLoS One , vol.7
    • Kim, S.1    Chang, K.A.2    Kim, J.3
  • 56
    • 73649147404 scopus 로고    scopus 로고
    • Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in parkinson's disease
    • NK Venkataramana, SK Kumar, S Balaraju, et al., Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease, Transl Res, 155, 62 (2010).
    • (2010) Transl Res , vol.155 , pp. 62
    • Venkataramana, N.K.1    Kumar, S.K.2    Balaraju, S.3
  • 57
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • OY Bang, JS Lee, PH Lee, et al., Autologous mesenchymal stem cell transplantation in stroke patients, Ann Neurol, 57, 874 (2005).
    • (2005) Ann Neurol , vol.57 , pp. 874
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3
  • 58
    • 77957964299 scopus 로고    scopus 로고
    • Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    • D Karussis, C Karageorgiou, A Vaknin-Dembinsky, et al., Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis, Arch Neurol, 67, 1187 (2010).
    • (2010) Arch Neurol , vol.67 , pp. 1187
    • Karussis, D.1    Karageorgiou, C.2    Vaknin-Dembinsky, A.3
  • 59
    • 84864488997 scopus 로고    scopus 로고
    • A randomized trial of mesenchymal stem cells in multiple system atrophy
    • PH Lee, JE Lee, HS Kim, et al., A randomized trial of mesenchymal stem cells in multiple system atrophy, Ann Neurol, 72, 32 (2012).
    • (2012) Ann Neurol , vol.72 , pp. 32
    • Lee, P.H.1    Lee, J.E.2    Kim, H.S.3
  • 60
    • 70450158749 scopus 로고    scopus 로고
    • Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: A pilot clinical study
    • R Pal, NK Venkataramana, A Bansal, et al., Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study, Cytotherapy, 11, 897 (2009).
    • (2009) Cytotherapy , vol.11 , pp. 897
    • Pal, R.1    Venkataramana, N.K.2    Bansal, A.3
  • 61
    • 77957744902 scopus 로고    scopus 로고
    • Case control series of intrathecal autologous bone marrow mesenchymal stem cell therapy for chronic spinal cord injury
    • NA Kishk, H Gabr, S Hamdy, et al., Case control series of intrathecal autologous bone marrow mesenchymal stem cell therapy for chronic spinal cord injury, Neurorehabil Neural Repair, 24, 702 (2010).
    • (2010) Neurorehabil Neural Repair , vol.24 , pp. 702
    • Kishk, N.A.1    Gabr, H.2    Hamdy, S.3
  • 62
    • 33846910469 scopus 로고    scopus 로고
    • Sarcoma derived from cultured mesenchymal stem cells
    • J Tolar, AJ Nauta, MJ Osborn, et al., Sarcoma derived from cultured mesenchymal stem cells, Stem cells, 25, 371 (2007).
    • (2007) Stem cells , vol.25 , pp. 371
    • Tolar, J.1    Nauta, A.J.2    Osborn, M.J.3
  • 63
    • 84875756240 scopus 로고    scopus 로고
    • Duration of in vitro storage affects the key stem cell features of human bone marrowderived mesenchymal stem cells for clinical transplantation
    • In Press
    • HS Sohn, JS Heo, HS Kim, et al., Duration of in vitro storage affects the key stem cell features of human bone marrowderived mesenchymal stem cells for clinical transplantation, Cytotherapy, In Press, (2013).
    • (2013) Cytotherapy
    • Sohn, H.S.1    Heo, J.S.2    Kim, H.S.3
  • 64
    • 0035144015 scopus 로고    scopus 로고
    • Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion
    • SM Devine, AM Bartholomew, N Mahmud, et al., Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion, Exp Hematol, 29, 244 (2001).
    • (2001) Exp Hematol , vol.29 , pp. 244
    • Devine, S.M.1    Bartholomew, A.M.2    Mahmud, N.3
  • 65
    • 31944450798 scopus 로고    scopus 로고
    • Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents
    • MA Hellmann, H Panet, Y Barhum, et al., Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents, Neurosci Lett, 395, 124 (2006).
    • (2006) Neurosci Lett , vol.395 , pp. 124
    • Hellmann, M.A.1    Panet, H.2    Barhum, Y.3
  • 66
    • 50849090271 scopus 로고    scopus 로고
    • Transplanted bone marrow stromal cells migrate, differentiate and improve motor function in rats with experimentally induced cerebral stroke
    • JR Chen, GY Cheng, CC Sheu, et al., Transplanted bone marrow stromal cells migrate, differentiate and improve motor function in rats with experimentally induced cerebral stroke, J Anat, 213, 249 (2008).
    • (2008) J Anat , vol.213 , pp. 249
    • Chen, J.R.1    Cheng, G.Y.2    Sheu, C.C.3
  • 67
    • 64149095138 scopus 로고    scopus 로고
    • A new role of substance p as an injury-inducible messenger for mobilization of cd29(+) stromal-like cells
    • HS Hong, J Lee, E Lee, et al., A new role of substance P as an injury-inducible messenger for mobilization of CD29(+) stromal-like cells, Nature Med, 15, 425 (2009).
    • (2009) Nature Med , vol.15 , pp. 425
    • Hong, H.S.1    Lee, J.2    Lee, E.3
  • 68
    • 77958572322 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Mechanisms of immunomodulation and homing
    • H Yagi, A Soto-Gutierrez, B Parekkadan, et al., Mesenchymal stem cells: mechanisms of immunomodulation and homing, Cell Transplant, 19, 667 (2010).
    • (2010) Cell Transplant , vol.19 , pp. 667
    • Yagi, H.1    Soto-Gutierrez, A.2    Parekkadan, B.3
  • 69
    • 0037106144 scopus 로고    scopus 로고
    • Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis
    • D Woodbury, K Reynolds, IB Black, Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis, J Neurosci Res, 69, 908 (2002).
    • (2002) J Neurosci Res , vol.69 , pp. 908
    • Woodbury, D.1    Reynolds, K.2    Black, I.B.3
  • 70
    • 0141796313 scopus 로고    scopus 로고
    • Mesenchymal stem cells modified with akt prevent remodeling and restore performance of infarcted hearts
    • AA Mangi, N Noiseux, D Kong, et al., Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts, Nature Med, 9, 1195 (2003).
    • (2003) Nature Med , vol.9 , pp. 1195
    • Mangi, A.A.1    Noiseux, N.2    Kong, D.3
  • 71
  • 72
    • 29144460856 scopus 로고    scopus 로고
    • Human stem/ progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice
    • JR Munoz, BR Stoutenger, AP Robinson, et al., Human stem/ progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice, Proc Natl Acad Sci USA, 102, 18171 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18171
    • Munoz, J.R.1    Stoutenger, B.R.2    Robinson, A.P.3
  • 73
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • AI Caplan, JE Dennis, Mesenchymal stem cells as trophic mediators, J Cell Biochem, 98, 1076 (2006).
    • (2006) J Cell Biochem , vol.98 , pp. 1076
    • Caplan, A.I.1    Dennis, J.E.2
  • 74
    • 32644434557 scopus 로고    scopus 로고
    • Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis
    • L Crigler, RC Robey, A Asawachaicharn, et al., Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis, Exp Neurol, 198, 54 (2006).
    • (2006) Exp Neurol , vol.198 , pp. 54
    • Crigler, L.1    Robey, R.C.2    Asawachaicharn, A.3
  • 75
    • 34147131808 scopus 로고    scopus 로고
    • Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts
    • VN Lama, L Smith, L Badri, et al., Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts, J Clin Invest, 117, 989 (2007).
    • (2007) J Clin Invest , vol.117 , pp. 989
    • Lama, V.N.1    Smith, L.2    Badri, L.3
  • 76
    • 0034489772 scopus 로고    scopus 로고
    • Human marrow-derived mesenchymal stem cells (mscs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages
    • MK Majumdar, MA Thiede, SE Haynesworth, et al., Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages, J Hematother Stem Cell Res, 9, 841 (2000).
    • (2000) J Hematother Stem Cell Res , vol.9 , pp. 841
    • Majumdar, M.K.1    Thiede, M.A.2    Haynesworth, S.E.3
  • 77
    • 1842486565 scopus 로고    scopus 로고
    • Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    • T Kinnaird, E Stabile, MS Burnett, et al., Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms, Circulation, 109, 1543 (2004).
    • (2004) Circulation , vol.109 , pp. 1543
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3
  • 78
    • 20244389882 scopus 로고    scopus 로고
    • Paracrine action accounts for marked protection of ischemic heart by akt-modified mesenchymal stem cells
    • M Gnecchi, H He, OD Liang, et al., Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells, Nature Med, 11, 367 (2005).
    • (2005) Nature Med , vol.11 , pp. 367
    • Gnecchi, M.1    He, H.2    Liang, O.D.3
  • 79
    • 44349134076 scopus 로고    scopus 로고
    • Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium
    • L Timmers, SK Lim, F Arslan, et al., Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium, Stem Cell Res, 1, 129 (2007).
    • (2007) Stem Cell Res , vol.1 , pp. 129
    • Timmers, L.1    Lim, S.K.2    Arslan, F.3
  • 80
    • 41549162430 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure
    • B Parekkadan, D van Poll, K Suganuma, et al., Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure, PLoS One, 2, e941 (2007).
    • (2007) PLoS One , vol.2
    • Parekkadan, B.1    Van Poll, D.2    Suganuma, K.3
  • 81
    • 84861868459 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
    • GF Curley, M Hayes, B Ansari, et al., Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat, Thorax, 67, 496 (2012).
    • (2012) Thorax , vol.67 , pp. 496
    • Curley, G.F.1    Hayes, M.2    Ansari, B.3
  • 82
    • 84869874224 scopus 로고    scopus 로고
    • Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats
    • TJ Chuang, KC Lin, CC Chio, et al., Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats, J Trauma Acute Care Surg, 73, 1161 (2012).
    • (2012) J Trauma Acute Care Surg , vol.73 , pp. 1161
    • Chuang, T.J.1    Lin, K.C.2    Chio, C.C.3
  • 83
    • 84863116200 scopus 로고    scopus 로고
    • Direct and indirect contribution of human embryonic stem cell-derived hepatocytelike cells to liver repair in mice
    • DH Woo, SK Kim, HJ Lim, et al., Direct and indirect contribution of human embryonic stem cell-derived hepatocytelike cells to liver repair in mice, Gastroenterology, 142, 602 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 602
    • Woo, D.H.1    Kim, S.K.2    Lim, H.J.3
  • 84
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cellderived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer of mrna and protein delivery
    • J Ratajczak, K Miekus, M Kucia, et al., Embryonic stem cellderived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery, Leukemia, 20, 847 (2006).
    • (2006) Leukemia , vol.20 , pp. 847
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3
  • 85
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mrnas and micrornas is a novel mechanism of genetic exchange between cells
    • H Valadi, K Ekström, A Bossios, et al., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nature Cell Biol, 9, 654 (2007).
    • (2007) Nature Cell Biol , vol.9 , pp. 654
    • Valadi, H.1    Ekström, K.2    Bossios, A.3
  • 86
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport rna and proteins that promote tumour growth and provide diagnostic biomarkers
    • J Skog, T Würdinger, S van Rijn, et al., Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nature Cell Biol, 10, 1470 (2008).
    • (2008) Nature Cell Biol , vol.10 , pp. 1470
    • Skog, J.1    Würdinger, T.2    Van Rijn, S.3
  • 87
    • 67349142591 scopus 로고    scopus 로고
    • Prostate cancer-derived urine exosomes: A novel approach to biomarkers for prostate cancer
    • J Nilsson, J Skog, A Nordstrand, et al., Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer, Br J Cancer, 100, 1603 (2009).
    • (2009) Br J Cancer , vol.100 , pp. 1603
    • Nilsson, J.1    Skog, J.2    Nordstrand, A.3
  • 88
    • 84862618600 scopus 로고    scopus 로고
    • Tumor-derived microvesicles: Shedding light on novel microenvironment modulators and prospective cancer biomarkers
    • C D'Souza-Schorey, JW Clancy, Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers, Genes Dev, 26, 1287 (2012).
    • (2012) Genes Dev , vol.26 , pp. 1287
    • D'Souza-Schorey, C.1    Clancy, J.W.2
  • 89
    • 79955571241 scopus 로고    scopus 로고
    • Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury
    • S Gatti, S Bruno, MC Deregibus, et al., Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury, Nephrol Dial Transplant, 26, 1474 (2011).
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 1474
    • Gatti, S.1    Bruno, S.2    Deregibus, M.C.3
  • 90
    • 84858185865 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury
    • S Bruno, C Grange, F Collino, et al., Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury, PLoS One, 7, e33115 (2012).
    • (2012) PLoS One , vol.7
    • Bruno, S.1    Grange, C.2    Collino, F.3
  • 91
    • 84862981326 scopus 로고    scopus 로고
    • Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model
    • J He, Y Wang, S Sun, et al., Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model, Nephrol, 17, 493 (2012).
    • (2012) Nephrol , vol.17 , pp. 493
    • He, J.1    Wang, Y.2    Sun, S.3
  • 92
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by msc reduces myocardial ischemia/reperfusion injury
    • RC Lai, F Arslan, MM Lee, et al., Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury, Stem Cell Res, 4, 214 (2010).
    • (2010) Stem Cell Res , vol.4 , pp. 214
    • Lai, R.C.1    Arslan, F.2    Lee, M.M.3
  • 93
    • 77955133368 scopus 로고    scopus 로고
    • Human liver stem cellderived microvesicles accelerate hepatic regeneration in hepatectomized rats
    • MB Herrera, V Fonsato, S Gatti, et al., Human liver stem cellderived microvesicles accelerate hepatic regeneration in hepatectomized rats, J Cell Mol Med, 14, 1605 (2010).
    • (2010) J Cell Mol Med , vol.14 , pp. 1605
    • Herrera, M.B.1    Fonsato, V.2    Gatti, S.3
  • 94
    • 77955643809 scopus 로고    scopus 로고
    • Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of mirnas
    • F Collino, MC Deregibus, S Bruno, et al., Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs, PLoS One, 5, e11803 (2010).
    • (2010) PLoS One , vol.5
    • Collino, F.1    Deregibus, M.C.2    Bruno, S.3
  • 95
    • 84863060761 scopus 로고    scopus 로고
    • Proteomic analysis of microvesicles derived from human mesenchymal stem cells
    • HS Kim, DY Choi, SJ Yun, et al., Proteomic analysis of microvesicles derived from human mesenchymal stem cells, J Proteome Res, 11, 839 (2012).
    • (2012) J Proteome Res , vol.11 , pp. 839
    • Kim, H.S.1    Choi, D.Y.2    Yun, S.J.3
  • 96
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of sirna to the mouse brain by systemic injection of targeted exosomes
    • L Alvarez-Erviti, Y Seow, H Yin, et al., Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nature Biotech, 29, 341 (2011).
    • (2011) Nature Biotech , vol.29 , pp. 341
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3
  • 97
    • 62749181868 scopus 로고    scopus 로고
    • Transfer of micrornas by embryonic stem cell microvesicles
    • A Yuan, EL Farber, AL Rapoport, et al., Transfer of microRNAs by embryonic stem cell microvesicles, PLoS One, 4, e4722 (2009).
    • (2009) PLoS One , vol.4
    • Yuan, A.1    Farber, E.L.2    Rapoport, A.L.3
  • 98
    • 79960554011 scopus 로고    scopus 로고
    • The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures)
    • CA Ribeiro, AJ Salgado, JS Fraga, et al., The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures), J Tissue Eng Regen Med, 5, 668 (2011).
    • (2011) J Tissue Eng Regen Med , vol.5 , pp. 668
    • Ribeiro, C.A.1    Salgado, A.J.2    Fraga, J.S.3
  • 99
    • 84861667226 scopus 로고    scopus 로고
    • The secretome of stem cells isolated from the adipose tissue and wharton jelly acts differently on central nervous system derived cell populations
    • CA Ribeiro, JS Fraga, M Grãos, et al., The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations, Stem Cell Res Ther, 3, 18 (2012).
    • (2012) Stem Cell Res Ther , vol.3 , pp. 18
    • Ribeiro, C.A.1    Fraga, J.S.2    Grãos, M.3
  • 100
    • 79959833632 scopus 로고    scopus 로고
    • Mesenchymal stem cell-conditioned medium triggers neuroinflammation and reactive species generation in organotypic cultures of rat hippocampus
    • AP Horn, A Bernardi, R Luiz Frozza, et al., Mesenchymal stem cell-conditioned medium triggers neuroinflammation and reactive species generation in organotypic cultures of rat hippocampus, Stem Cells Dev, 20, 1171 (2011).
    • (2011) Stem Cells Dev , vol.20 , pp. 1171
    • Horn, A.P.1    Bernardi, A.2    Luiz Frozza, R.3
  • 101
    • 84872039899 scopus 로고    scopus 로고
    • Hypoxic preconditioning enhances the therapeutic potential of the secretome from cultured human mesenchymal stem cells in experimental traumatic brain injury
    • CP Chang, CC Chio, CU Cheong, et al., Hypoxic preconditioning enhances the therapeutic potential of the secretome from cultured human mesenchymal stem cells in experimental traumatic brain injury, Clin Science, 124, 165 (2013).
    • (2013) Clin Science , vol.124 , pp. 165
    • Chang, C.P.1    Chio, C.C.2    Cheong, C.U.3


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