In vivo hepatic differentiation potential of human cord blood-derived mesenchymal stem cells

International Journal of Molecular Medicine

Volumn 27, Issue 5, 2011, Pages 701-706

  Kim, Sinyoung ^a   Kim, Han Soo ^a   Lee, Eugene ^a   Kim, Hyun O K ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Cord blood; Hepatic differentiation; Mesenchymal stem cell

Indexed keywords

BIOCHEMICAL MARKER; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER FUNCTION; LIVER INJURY; MESENCHYMAL STEM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT;

ALANINE TRANSAMINASE; AMMONIA; ANIMALS; ANTIGENS, DIFFERENTIATION; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; CELL DIFFERENTIATION; FEMALE; FETAL BLOOD; HUMANS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; RATS; RATS, WISTAR; SERUM ALBUMIN; THIOACETAMIDE;

EID: 79952905311     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.627     Document Type: Article

References (27)

1. Lee SW, Wang X, Chowdhury NR and Roy-Chowdhury J: Hepatocyte transplantation: state of the art and strategies for overcoming existing hurdles. Ann Hepatol 3: 48-53, 2004.
2. Walldorf J, Aurich H, Cai H, Runge D, Christ B, Strom SC and Fleig WE: Expanding hepatocytes in vitro before cell transplantation: donor age-dependent proliferative capacity of cultured human hepatocytes. Scand J Gastroenterol 39: 584-593, 2004. (Pubitemid 38916266)
3. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS and Goff JP: Bone marrow as a potential source of hepatic oval cells. Science 284: 1168-1170, 1999. (Pubitemid 29288406)
4. Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O and Krause DS: Liver from bone marrow in humans. Hepatology 32: 11-16, 2000. (Pubitemid 30432360)
5. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A and Anversa P: Bone marrow cells regenerate infarcted myocardium. Nature 410: 701-705, 2001.
6. Eglitis MA and Mezey E: Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci USA 94: 4080-4085, 1997. (Pubitemid 27180502)
7. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S and Sharkis SJ: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105: 369-377, 2001. (Pubitemid 32455343)
8. Schwartz E, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS and Verfaillie CM: Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 109: 1291-1302, 2002. (Pubitemid 34546893)
9. Thorgeirsson SS and Grisham JW: Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence. Hepatology 43: 2-8, 2006. (Pubitemid 43733584)
10. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AW, Behnaim P, Lorenz HP and Hedrick MH: Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211-228, 2001. (Pubitemid 32295155)
11. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147, 1999. (Pubitemid 29282067)
12. Bieback K, Kern S, Klüter H and Eichler H: Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells 22: 625-634, 2004. (Pubitemid 39014578)
13. de Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S and Atala A: Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 25: 100-106, 2007. (Pubitemid 46087908)
14. In 't Anker PS, Scherjon SA, Kleijburg-van der Keur C, de Groot-Swings GM, Claas FH, Fibbe WE and Kanhai HH: Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells 22: 1338-1345, 2004.
15. Lee KD, Kuo TK, Whang-Peng J, Chung YF, Lin CT, Chou SH, Chen JR, Chen YP and Lee OK: In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40: 1275-1284, 2004.
16. Wang X, Ge S, McNamara G, Hao QL, Crooks GM and Nolta JA: Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood 101: 4201-4208, 2003. (Pubitemid 36857905)
17. Hengstler JG, Brulport M, Schormann W, Bauer A, Hermes M, Nussler AK, Fandrich F, Ruhnke M, Ungefroren H, Griffin L, Bockamp E, Oesch F and von Mach MA: Generation of human hepatocytes by stem cell technology: definition of the hepatocyte. Expert Opin Drug Metab Toxicol 1: 61-74, 2005.
18. Fang B, Shi M, Liao L, Yang S, Liu Y and Zhao RC: Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation 78: 83-88, 2004.
19. Seo MJ, Suh SY, Bae YC and Jung JS: Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun 328: 258-264, 2005. (Pubitemid 40164663)
20. di Bonzo LV, Ferrero I, Cravanzola C, Mareschi K, Rustichell D, Novo E, Sanavio F, Cannito S, Zamara E, Bertero M, Davit A, Francica S, Novelli F, Colombatto S, Fagioli F and Parola M: Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential. Gut 57: 223-231, 2008. (Pubitemid 351158051)
21. Nakamura T, Torimura T, Sakamoto M, Hashimoto O, Taniguchi E, Inoue K, Sakata R, Kumashiro R, Murohara T, Ueno T and Sata M: Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model. Gastroenterology 133: 91-107, 2007.
22. Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H and Okita K: Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 40: 1304-1311, 2004. (Pubitemid 39657004)
23. Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL and Chen TH: Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103: 1669-1675, 2004. (Pubitemid 38268958)
24. Hong SH, Gang EJ, Jeong JA, Ahn C, Hwang SH, Yang IH, Park HK, Han H and Kim H: In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun 330: 1153-1161, 2005.
25. Snykers S, Vanhaecke T, Papeleu P, Luttun A, Jiang Y, Vander Heyden Y, Verfaillie C and Rogiers V: Sequential exposure to cytokines reflecting embryogenesis: the key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells. Toxicol Sci 94: 330-341, 2006. (Pubitemid 44817149)
26. Oyagi S, Hirose M, Kojima M, Okuyama M, Kawase M, Nakamura T, Ohgushi H and Yagi K: Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J Hepatol 44: 742-748, 2006.
27. Russo FP, Alison MR, Bigger BW, Amofah E, Florou A, Amin F, Bou-Gharios G, Jeffery R, Iredale JP and Forbes SJ: The bone marrow functionally contributes to liver fibrosis. Gastroenterology 130: 1807-1821, 2006.