Cutting edge communication: Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages

Journal of Hematotherapy and Stem Cell Research

Volumn 9, Issue 6, 2000, Pages 841-848

  Majumdar, M K ^a,c   Thiede, M A ^a   Haynesworth, S E ^b   Bruder, S P ^d   Gerson, S L ^b  

^a OSIRIS THERAPEUTICS INC   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c PFIZER INC   (United States)

^d Anika Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; DEXAMETHASONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; MESSENGER RNA; STEM CELL FACTOR; CYTOKINE; INTERLEUKIN 1;

ADIPOSE TISSUE; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL FATE; CHONDROGENESIS; CYTOKINE PRODUCTION; HEMATOPOIESIS; HUMAN; HUMAN CELL; MESENCHYME; PRIORITY JOURNAL; STEM CELL; TENDON; BONE MARROW CELL; CELL LINEAGE; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MESODERM; METABOLISM; PHYSIOLOGY; STROMA CELL;

BONE MARROW CELLS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CULTURE MEDIA; CYTOKINES; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HUMANS; INTERLEUKIN-1; MESODERM; OSTEOGENESIS; RNA, MESSENGER; STEM CELLS; STROMAL CELLS;

EID: 0034489772     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/152581600750062264     Document Type: Article

References (19)

1. Multilineage potential of adult human mesenchymal stem cells
2. Cell surface antigens on human marrow derived mesenchymal cells are detected by monoclonal antibodies
3. Porous ceramic vehicles for rat marrow-derived (Rattus norvegicus) osteogenic cell delivery: Effects of pretreatment of fibronectin or laminin
4. In vitro chondrogenesis of bone marrow-derived mesenchymal cells
5. Human mesenchymal stem cells can be directed into chondrocytes, adipocytes and osteocytes
6. Characterization of cells with osteogenic potential from the human marrow
7. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells
8. Cytokine expression by human marrow derived mesenchymal progenitor cells in vitro: Effects of dexamethasone and IL-1a
9. Conditions controlling the proliferation of hematopoietic stem cells in vitro
10. IL-1α and TNF-α act synergistically to stimulate production of myeloid colony-stimulating factors by cultured human bone marrow stromal cells and cloned stromal cell lines
11. Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor
12. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long term human bone marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer
13. Interleukin messenger RNA expression and Interleukin protein secretion in cells isolated from normal human bone marrow: Regulation by interleukin-1
14. Production of various cytokines by normal human osteoblast-like cells in response to IL-1β and Tumor Necrosis Factor-α
15. PCR detection of cytokines in normal human and pagetic osteoblast-like cells
16. Ex vivo expansion & subsequent infusion of human bone marrow (BM)-derived stromal progenitor cells (mesenchymal stem cells [MSC]): Implications for therapeutic use
17. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high dose chemotherapy
18. Osteogenic induction of purified human mesenchymal stem cells in vitro: Quantitative assessment of the osteoblastic phenotype
19. Lacz and IL-3 expression in vivo in retrovirally transduced marrow-derived human osteogenic mesenchymal progenitors