Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Wang, Xue ^a   Kim, Jun Ran ^b   Lee, Seong Baek ^c   Kim, Young Joon ^d   Jung, Moon Y ^b   Kwon, Hyung Wook ^b   Ahn, Young Joon ^b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Cellumed Co   (South Korea)

^d Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Alzheimer's disease; BACE 1; Curcuma longa; Curcuminoids; Drosophila melanogaster; Structure activity relationship

Indexed keywords

AMYLOID BETA PROTEIN; BETA AMYLOID PRECURSOR CLEAVAGE 1; CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; EPIGALLOCATECHIN GALLATE; FUNCTIONAL GROUP; UNCLASSIFIED DRUG; PLANT EXTRACT; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BEHAVIOR DISORDER; CLIMBING; CONTROLLED STUDY; CURCUMA LONGA; DIET SUPPLEMENTATION; DROSOPHILA MELANOGASTER; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; FEEDING; FEMALE; HYDROPHOBICITY; IC 50; IN VITRO STUDY; LIFESPAN; LOCOMOTION; MALE; MOTOR ACTIVITY; NERVE CELL; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RHIZOME; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; CURCUMA; DISEASE MODEL; DROSOPHILA; DRUG EFFECTS; EYE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; LONGEVITY; METABOLISM;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BEHAVIOR, ANIMAL; CURCUMA; CURCUMIN; DISEASE MODELS, ANIMAL; DROSOPHILA; EYE; FEMALE; HUMANS; LONGEVITY; MALE; PLANT EXTRACTS; RHIZOME;

EID: 84896722238     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-88     Document Type: Article

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