The inhibitory effects of different curcuminoids on β-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells

Neuroscience Letters

Volumn 485, Issue 2, 2010, Pages 83-88

  Liu, Hongying ^a,b   Li, Zhong ^a   Qiu, Donghai ^a   Gu, Qiong ^a   Lei, Qingfeng ^a   Mao, Li ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Amyloid precursor protein; Amyloid protein; Site amyloid precursor protein cleaving enzyme 1; Alzheimer's disease; Curcumin; Curcuminoids

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CELL SURVIVAL; CURCUMIN; HEK293 CELLS; HUMANS; MUTATION; PEPTIDE FRAGMENTS;

EID: 77957337974     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.08.035     Document Type: Article

References (31)

1. Adlerz L., Beckman M., Holback S., Tehranian R. Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction. Brain Res. Mol. Brain Res. 2003, 119(1):62-72.
2. Baum L., Lam C.W., Cheung S.K., Kwok T., Lui V., Tsoh J., Lam L., Leung V., Hui E., Ng C., Woo J., Chiu H.F., Goggins W.B., Zee B.C., Cheng K.F., Fong C.Y., Wong A., Mok H., Chow M.S., Ho P.C., Ip S.P., Ho C.S., Yu X.W., Lai C.Y., Chan M.H., Szeto S., Chan I.H., Mok V. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J. Clin. Psychopharmacol. 2008, 28(1):110-113.
3. Bos R., Windono T., Woerdenbag H.J., Boersma Y.L., Koulman A., Kayser O. HPLC-photodiode array detection analysis of curcuminoids in Curcuma species indigenous to Indonesia. Phytochem. Anal. 2007, 18(2):118-122.
4. Cai H., Wang Y., McCarthy D., Wen H., Borchelt D.R., Price D.L., Wong P.C. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 2001, 4(3):233-234.
5. Chandra V., Pandav R., Dodge H.H., Johnston J.M., Belle S.H., DeKosky S.T., Ganguli M. Incidence of Alzheimer's disease in a rural community in India: the Indo-US study. Neurology 2001, 57(6):985-989.
6. Garcia-Alloza M., Borrelli L.A., Rozkalne A., Hyman B.T., Bacskai B.J. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J. Neurochem. 2007, 102(4):1095-1104.
7. Ghosh A.K., Bilcer G., Harwood C., Kawahama R., Shin D., Hussain K.A., Hong L., Loy J.A., Nguyen C., Koelsch G., Ermolieff J., Tang J. Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase). J. Med. Chem. 2001, 44(18):2865-2868.
8. Hattori C., Asai M., Onishi H., Sasagawa N., Hashimoto Y., Saido T.C., Maruyama K., Mizutani S., Ishiura S. BACE1 interacts with lipid raft proteins. J. Neurosci. Res. 2006, 84(4):912-917.
9. Hébert S.S., Horré K., Nicolaï L., Papadopoulou A.S., Mandemakers W., Silahtaroglu A.N., Kauppinen S., Delacourte A. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc. Natl. Acad. Sci. U.S.A. 2008, 105(17):6415-6420.
10. Holsinger R.M., McLean C.A., Beyreuther K., Masters C.L., Evin G. Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann. Neurol. 2002, 51(6):783-786.
11. Kim D.S., Park S.Y., Kim J.K. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1±42) insult. Neurosci. Lett. 2001, 303(1):57-61.
12. Lim G.P., Chu T., Yang F., Beech W., Frautschy S.A., Cole G.M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 2001, 21(21):8370-8377.
13. Lin R., Chen X., Li W., Han Y., Liu P., Pi R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci. Lett. 2008, 440(3):344-347.
14. Ng T.P., Chiam P.C., Lee T., Chua H.C., Lim L., Kua E.H. Curry consumption and cognitive function in the elderly. Am. J. Epidemiol. 2006, 164(9):898-906.
15. Niwa R., Zhou F., Li C., Slack F.J. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev. Biol. 2008, 315(2):418-425.
16. Ono K., Hasegawa K., Naiki H., Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J. Neurosci. Res. 2004, 75(6):742-750.
17. Palmert M.R., Podlisny M.B., Witker D.S., Oltersdorf T., Younkin L.H., Selkoe D.J., Younkin S.G. The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc. Natl. Acad. Sci. U.S.A. 1989, 86(16):6338-6342.
18. Patel N., Hoang D., Miller N., Ansaloni S., Huang Q., Rogers J.T., Lee J.C., Saunders A.J. MicroRNAs can regulate human APP levels. Mol. Neurodegener. 2008, 3:10.
19. Roberds S.L., Anderson J., Basi G., Bienkowski M.J., Branstetter D.G., Chen K.S., Freedman S.B., Frigon N.L., Games D., Hu K., Johnson-Wood K., Kappenman K.E., Kawabe T.T., Kola I., Kuehn R., Lee M., Liu W., Motter R., Nichols N.F., Power M., Robertson D.W., Schenk D., Schoor M., Shopp G.M., Shuck M.E., Sinha S., Svensson K.A., Tatsuno G., Tintrup H., Wijsman J., Wright S., McConlogue L. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum. Mol. Genet. 2001, 10(12):1317-1324.
20. Sandur S.K., Pandey M.K., Sung B., Ahn K.S., Murakami A., Sethi G., Limtrakul P., Badmaev V., Aggarwal B.B. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 2007, 28(8):1765-1773.
21. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81(2):741-766.
22. Selkoe D.J., Yamazaki T., Citron M., Podlisny M.B., Koo E.H., Teplow D.B., Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann. N. Y. Acad. Sci. 1996, 777:57-64.
23. Shimmyo Y., Kihara T., Akaike A., Niidome T., Sugimoto H. Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. Neuroreport 2008, 19(13):1329-1333.
24. Shytle R.D., Bickford P.C., Rezai-zadeh K., Hou L., Zeng J., Tan J., Sanberg P.R., Sanberg C.D., Roschek B., Fink R.C., Alberte R.S. Optimized Turmeric Extracts Have Potent Anti-amyloidogenic Effects. Curr. Alzheimer Res. 2009, 6(6):564-571.
25. Somparn P., Phisalaphong C., Nakornchai S., Unchern S., Morales N.P. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol. Pharm. Bull. 2007, 30(1):74-78.
26. Sun M., Estrov Z., Ji Y., Coombes K.R., Harris D.H., Kurzrock R. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol. Cancer Ther. 2008, 7(3):464-473.
27. Tamagno E., Bardini P., Guglielmotto M., Danni O., Tabaton M. The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression. Free Radic. Biol. Med. 2006, 41(2):202-212.
28. Tanzi R.E., Gusella J.F., Watkins P.C., Bruns G.A., St George-Hyslop P., Van Keuren M.L., Patterson D., Pagan S., Kurnit D.M., Neve R.L. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987, 235(4791):880-884.
29. Vardy E.R, Catto A.J., Hooper N.M. Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol. Med. 2005, 11(10):464-472.
30. Xue S., Jia L., Jia J. Hypoxia and reoxygenation increased BACE1 mRNA and protein levels in human neuroblastoma SH-SY5Y cells. Neurosci. Lett. 2006, 405(3):231-235.
31. Yang F., Lim G.P., Begum A.N., Ubeda O.J., Simmons M.R., Ambegaokar S.S., Chen P.P., Kayed R., Glabe C.G., Frautschy S.A., Cole G.M. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J. Biol. Chem. 2005, 280(7):5892-5901.