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Volumn 66, Issue , 2014, Pages 113-121

Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines

Author keywords

Comet; Deoxynivalenol; Genotoxicity; HepaRG; Micronucleus; TK6

Indexed keywords

CASPASE 3; CASPASE 7; VOMITOXIN; MYCOTOXIN; TRICHOTHECENE DERIVATIVE;

EID: 84896718518     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.01.029     Document Type: Article
Times cited : (22)

References (41)
  • 1
    • 84896733468 scopus 로고    scopus 로고
    • Évaluation des risques liés à la présence de mycotoxines dans les chaînes alimentaires humaine et animale.
    • AFSSA
    • AFSSA, 2009. Évaluation des risques liés à la présence de mycotoxines dans les chaînes alimentaires humaine et animale.
    • (2009)
  • 2
    • 0016685233 scopus 로고
    • Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test
    • Ames B., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 1975, 31:347-363.
    • (1975) Mutat. Res. , vol.31 , pp. 347-363
    • Ames, B.1    McCann, J.2    Yamasaki, E.3
  • 3
    • 84862582252 scopus 로고    scopus 로고
    • The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human
    • Andersson T.B., Kanebratt K.P., Kenna J.G. The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human. Expert Opin. Drug Metab. Toxicol. 2012, 8:909-920.
    • (2012) Expert Opin. Drug Metab. Toxicol. , vol.8 , pp. 909-920
    • Andersson, T.B.1    Kanebratt, K.P.2    Kenna, J.G.3
  • 7
    • 77950351190 scopus 로고    scopus 로고
    • Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco 2 and HepaRG
    • Bazin E., Mourot A., Humpage A.R., Fessard V. Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco 2 and HepaRG. Environ. Mol. Mutagen. 2010, 51:251-259.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 251-259
    • Bazin, E.1    Mourot, A.2    Humpage, A.R.3    Fessard, V.4
  • 9
    • 33747762650 scopus 로고    scopus 로고
    • Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay
    • Bony S., Carcelen M., Olivier L., Devaux A. Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay. Toxicol. Lett. 2006, 166:67-76.
    • (2006) Toxicol. Lett. , vol.166 , pp. 67-76
    • Bony, S.1    Carcelen, M.2    Olivier, L.3    Devaux, A.4
  • 11
    • 49649091842 scopus 로고    scopus 로고
    • Mutagenic potency in Salmonella typhimurium of organic extracts of soil samples originating from urban, suburban, agricultural, forest and natural areas
    • Courty B., Le Curieux F., Belkessam L., Laboudigue A., Marzin D. Mutagenic potency in Salmonella typhimurium of organic extracts of soil samples originating from urban, suburban, agricultural, forest and natural areas. Mutat. Res. 2008, 653:1-5.
    • (2008) Mutat. Res. , vol.653 , pp. 1-5
    • Courty, B.1    Le Curieux, F.2    Belkessam, L.3    Laboudigue, A.4    Marzin, D.5
  • 12
    • 8844247487 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Deoxynivalenol (DON) as undesirable substance in animal feed
    • EFSA
    • EFSA, 2004. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Deoxynivalenol (DON) as undesirable substance in animal feed. EFSA J. 73, 1-41.
    • (2004) EFSA J. , vol.73 , pp. 1-41
  • 13
    • 85067915354 scopus 로고    scopus 로고
    • Scientific opinion on genotoxicity testing strategies applicable to food and feed safety assessment
    • EFSA
    • EFSA, 2011. Scientific opinion on genotoxicity testing strategies applicable to food and feed safety assessment. EFSA J. 9, 1-69.
    • (2011) EFSA J. , vol.9 , pp. 1-69
  • 14
    • 77953806816 scopus 로고    scopus 로고
    • A strategy to study genotoxicity: application to aquatic toxins, limits and solutions
    • Fessard V., Le Hegarat L. A strategy to study genotoxicity: application to aquatic toxins, limits and solutions. Anal. Bioanal. Chem. 2010, 397:1715-1722.
    • (2010) Anal. Bioanal. Chem. , vol.397 , pp. 1715-1722
    • Fessard, V.1    Le Hegarat, L.2
  • 15
    • 84856111701 scopus 로고    scopus 로고
    • Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. I. Choice of cell type
    • Fowler P., Smith K., Young J., Jeffrey L., Kirkland D., Pfuhler S., Carmichael P. Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. I. Choice of cell type. Mutat. Res. 2012, 742:11-25.
    • (2012) Mutat. Res. , vol.742 , pp. 11-25
    • Fowler, P.1    Smith, K.2    Young, J.3    Jeffrey, L.4    Kirkland, D.5    Pfuhler, S.6    Carmichael, P.7
  • 16
    • 84862331466 scopus 로고    scopus 로고
    • Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement
    • Fowler P., Smith R., Smith K., Young J., Jeffrey L., Kirkland D., Pfuhler S., Carmichael P. Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement. Mutat. Res. 2012, 747:104-117.
    • (2012) Mutat. Res. , vol.747 , pp. 104-117
    • Fowler, P.1    Smith, R.2    Smith, K.3    Young, J.4    Jeffrey, L.5    Kirkland, D.6    Pfuhler, S.7    Carmichael, P.8
  • 17
    • 84859163249 scopus 로고    scopus 로고
    • Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
    • Gerets H., Tilmant K., Gerin B., Chanteux H., Depelchin B., Dhalluin S., Atienzar F. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol. Toxicol. 2012, 28:69-87.
    • (2012) Cell Biol. Toxicol. , vol.28 , pp. 69-87
    • Gerets, H.1    Tilmant, K.2    Gerin, B.3    Chanteux, H.4    Depelchin, B.5    Dhalluin, S.6    Atienzar, F.7
  • 18
    • 84861466287 scopus 로고    scopus 로고
    • Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage
    • He K., Zhou H.R., Pestka J.J. Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. Toxicol. Sci. 2012, 127:382-390.
    • (2012) Toxicol. Sci. , vol.127 , pp. 382-390
    • He, K.1    Zhou, H.R.2    Pestka, J.J.3
  • 19
    • 79960999090 scopus 로고    scopus 로고
    • Cytotoxicity measurement in in vitro chromosome aberration test and micronucleus test
    • Honma M. Cytotoxicity measurement in in vitro chromosome aberration test and micronucleus test. Mutat. Res. 2011, 724:86-87.
    • (2011) Mutat. Res. , vol.724 , pp. 86-87
    • Honma, M.1
  • 20
    • 84860188521 scopus 로고    scopus 로고
    • An adaptation of the human HepaRG cells to the in vitro micronucleus assay
    • Jossé R., Rogue A., Lorge E., Guillouzo A. An adaptation of the human HepaRG cells to the in vitro micronucleus assay. Mutagenesis 2012, 27:295-304.
    • (2012) Mutagenesis , vol.27 , pp. 295-304
    • Jossé, R.1    Rogue, A.2    Lorge, E.3    Guillouzo, A.4
  • 21
    • 79951679077 scopus 로고    scopus 로고
    • A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins
    • Kirkland D., Reeve L., Gatehouse D., Vanparys P. A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins. Mutat. Res. 2011, 721:27-73.
    • (2011) Mutat. Res. , vol.721 , pp. 27-73
    • Kirkland, D.1    Reeve, L.2    Gatehouse, D.3    Vanparys, P.4
  • 23
    • 0342437504 scopus 로고    scopus 로고
    • Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes
    • Knasmuller S., Bresgen N., Kassie F., Mersch-Sundermann V., Gelderblom W., Zohrer E., Eckl P.M. Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes. Mutat. Res. 1997, 391:39-48.
    • (1997) Mutat. Res. , vol.391 , pp. 39-48
    • Knasmuller, S.1    Bresgen, N.2    Kassie, F.3    Mersch-Sundermann, V.4    Gelderblom, W.5    Zohrer, E.6    Eckl, P.M.7
  • 25
    • 22344452122 scopus 로고    scopus 로고
    • Estimated dietary exposure to principal food mycotoxins from the first French Total Diet Study
    • Leblanc J.C., Tard A., Volatier J.L., Verger P. Estimated dietary exposure to principal food mycotoxins from the first French Total Diet Study. Food Addit. Contam. 2005, 22:652-672.
    • (2005) Food Addit. Contam. , vol.22 , pp. 652-672
    • Leblanc, J.C.1    Tard, A.2    Volatier, J.L.3    Verger, P.4
  • 26
    • 77958084075 scopus 로고    scopus 로고
    • Comparison of different cytotoxicity measurements for the in vitro micronucleus assay using L5178Y and TK6 cells in support of OECD draft Test Guideline 487
    • Lorge E. Comparison of different cytotoxicity measurements for the in vitro micronucleus assay using L5178Y and TK6 cells in support of OECD draft Test Guideline 487. Mutat. Res. 2010, 702:199-207.
    • (2010) Mutat. Res. , vol.702 , pp. 199-207
    • Lorge, E.1
  • 27
    • 50349083414 scopus 로고    scopus 로고
    • Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects
    • Lorge E., Hayashi M., Albertini S., Kirkland D. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects. Mutat. Res. 2008, 655:1-3.
    • (2008) Mutat. Res. , vol.655 , pp. 1-3
    • Lorge, E.1    Hayashi, M.2    Albertini, S.3    Kirkland, D.4
  • 28
    • 84862825477 scopus 로고    scopus 로고
    • A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells
    • Ma Y., Zhang A., Shi Z., He C., Ding J., Wang X., Ma J., Zhang H. A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. Toxicol. In Vitro 2012, 26:414-420.
    • (2012) Toxicol. In Vitro , vol.26 , pp. 414-420
    • Ma, Y.1    Zhang, A.2    Shi, Z.3    He, C.4    Ding, J.5    Wang, X.6    Ma, J.7    Zhang, H.8
  • 29
    • 0003062746 scopus 로고
    • Analysis of data from microbial colony assays.
    • In: Kirkland, D. (Ed.), Statistical Evaluation of Mutagenicity test Data - UKEMS Sub-Committee on Guidelines for Mutagenicity Testing, Report Part III. Cambridge, New-York
    • Mahon, G.A.T., Middleton, B., Robinson, W.D., Green, M.H.L., Mitchell, I., Tweats, D.J., 1989. Analysis of data from microbial colony assays. In: Kirkland, D. (Ed.), Statistical Evaluation of Mutagenicity test Data - UKEMS Sub-Committee on Guidelines for Mutagenicity Testing, Report Part III. Cambridge, New-York, pp. 26-65.
    • (1989) , pp. 26-65
    • Mahon, G.A.T.1    Middleton, B.2    Robinson, W.D.3    Green, M.H.L.4    Mitchell, I.5    Tweats, D.J.6
  • 30
    • 0020533372 scopus 로고
    • Revised methods for the Salmonella mutagenicity test
    • Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
    • (1983) Mutat. Res. , vol.113 , pp. 173-215
    • Maron, D.M.1    Ames, B.N.2
  • 31
    • 77958108582 scopus 로고    scopus 로고
    • Cytosine arabinoside, vinblastine, diethylstilboestrol and 2-aminoanthracene tested in the in vitro human TK6 cell line micronucleus test (MNvit) at Institut Pasteur de Lille in support of OECD draft test guideline 487
    • Nesslany F., Marzin D. Cytosine arabinoside, vinblastine, diethylstilboestrol and 2-aminoanthracene tested in the in vitro human TK6 cell line micronucleus test (MNvit) at Institut Pasteur de Lille in support of OECD draft test guideline 487. Mutat. Res. 2010, 702:212-218.
    • (2010) Mutat. Res. , vol.702 , pp. 212-218
    • Nesslany, F.1    Marzin, D.2
  • 32
    • 68349133588 scopus 로고    scopus 로고
    • Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay
    • Nesslany F., Simar-Meintières S., Ficheux H., Marzin D. Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay. Mutat. Res. 2009, 678:13-19.
    • (2009) Mutat. Res. , vol.678 , pp. 13-19
    • Nesslany, F.1    Simar-Meintières, S.2    Ficheux, H.3    Marzin, D.4
  • 33
    • 84868538327 scopus 로고    scopus 로고
    • A critique of methods to measure cytotoxicity in mammalian cell genotoxicity assays
    • O'Donovan M. A critique of methods to measure cytotoxicity in mammalian cell genotoxicity assays. Mutagenesis 2012, 27:615-621.
    • (2012) Mutagenesis , vol.27 , pp. 615-621
    • O'Donovan, M.1
  • 34
    • 84896731296 scopus 로고    scopus 로고
    • OECD, Test No. 471: Bacterial Reverse Mutation Test. OECD Publishing.
    • OECD, 1997. Test No. 471: Bacterial Reverse Mutation Test. OECD Publishing.
    • (1997)
  • 35
    • 84896713055 scopus 로고    scopus 로고
    • OECD, Test No. 487. In Vitro Mammalian Cell Micronucleus Test. OECD Publishing.
    • OECD, 2010. Test No. 487. In Vitro Mammalian Cell Micronucleus Test. OECD Publishing.
    • (2010)
  • 37
    • 10044297379 scopus 로고    scopus 로고
    • Baseline levels of chromosome instability in the human lymphoblastoid cell TK6
    • Schwartz J.L., Jordan R., Evans H.H., Lenarczyk M., Liber H.L. Baseline levels of chromosome instability in the human lymphoblastoid cell TK6. Mutagenesis 2004, 19:477-482.
    • (2004) Mutagenesis , vol.19 , pp. 477-482
    • Schwartz, J.L.1    Jordan, R.2    Evans, H.H.3    Lenarczyk, M.4    Liber, H.L.5
  • 38
    • 77249135763 scopus 로고    scopus 로고
    • Coupling cytotoxicity biomarkers with DNA damage assessment in TK6 human lymphoblast cells
    • Shi J., Springer S., Escobar P. Coupling cytotoxicity biomarkers with DNA damage assessment in TK6 human lymphoblast cells. Mutat. Res. 2010, 696:167-178.
    • (2010) Mutat. Res. , vol.696 , pp. 167-178
    • Shi, J.1    Springer, S.2    Escobar, P.3
  • 39
    • 84869132263 scopus 로고    scopus 로고
    • Dietary exposure to mycotoxins and health risk assessment in the second French total diet study
    • Sirot V., Fremy J.-M., Leblanc J.-C. Dietary exposure to mycotoxins and health risk assessment in the second French total diet study. Food Chem. Toxicol. 2013, 52:1-11.
    • (2013) Food Chem. Toxicol. , vol.52 , pp. 1-11
    • Sirot, V.1    Fremy, J.-M.2    Leblanc, J.-C.3
  • 40
    • 0017880759 scopus 로고
    • Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins
    • Wehner F.C., Marasas W.F., Thiel P.G. Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins. Appl. Environ. Microbiol. 1978, 35:659-662.
    • (1978) Appl. Environ. Microbiol. , vol.35 , pp. 659-662
    • Wehner, F.C.1    Marasas, W.F.2    Thiel, P.G.3


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