Comparison of different cytotoxicity measurements for the in vitro micronucleus assay using L5178Y and TK6 cells in support of OECD draft Test Guideline 487

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 702, Issue 2, 2010, Pages 199-207

  Lorge, Elisabeth ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

2 Aminoanthracene; 5 Fluorouracil; Cadmium chloride; Cytotoxicity; Micronucleus assay; Mitomycin C; Vinblastine sulphate

Indexed keywords

2 AMINOANTHRACENE; CADMIUM CHLORIDE; FLUOROURACIL; MITOMYCIN C; VINBLASTINE SULFATE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINESIS; CYTOTOXICITY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOBLASTOID CELL LINE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL COUNT; CELL LINE; CELL LINE, TUMOR; CYTOTOXINS; GUIDELINES AS TOPIC; HUMANS; LEUKEMIA L5178; MICE; MICRONUCLEUS TESTS; MUTAGENS;

EID: 77958084075     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.03.002     Document Type: Article

References (9)

1. OECD (draft). In vitro Mammalian Cell Micronucleus Test (Mnvit). OECD Guideline for Testing of Chemicals No. 487, OECD, Paris. Available at: []. http://www.oecd.org/env/testguidelines.
2. Kirkland D. Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNvit): introduction to the collaborative trial. Mutat. Res. 2010, 702:199-207.
3. Miller B., Potter-Locher F., Seelbach A., Stopper H., Utesch D., Madle S. Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Mutat. Res. 1998, 410:81-116.
4. Moore M.M., Honma M., Clements J., Awogi T., Bolcsfoldi G., Cole J., Gollapudi B., Harrington-rock K., Mitchell A., Muster W., Myhr B., O'Donovan M., Ouldelhkim M.-C., San R., Shimada H., Stankowski L. The mouse lymphoma thymidine kinase locus (Tk) gene mutation assay: International Workshop on Genotoxicity Test Procedures (IWGTP) Workgroup Report. Environ. Mol. Mutagen. 2000, 35:185-190.
5. Fenech M., Chang W.P., Kirsch-Volders M., Holland N., Bonassi S., Zeiger E. HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat. Res. 2003, 534:65-75.
6. Lorge E., Hayashi M., Albertini S., Kirkland D. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. Mutat. Res. 2008, 655:1-3.
7. Fellows M.D., O'Donovan M.R., Lorge E., Kirkland D. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test, using examples with toxic agents. Mutat. Res. 2008, 655:4-21.
8. Fellows M.D., O'Donovan M.R. Cytotoxicity in cultured mammalian cells is a function of the method used to estimate it. Mutagenesis 2007, 22:275-280.
9. Greenwood S., Hill R., Sun J., Armstrong M., Johnson T., Gara T., Galloway S.M. Population doubling: a simple and more accurate estimation of cell growth suppression in the in vitro assay for chromosomal aberrations that reduces irrelevant positive results. Environ. Mol. Mutagen. 2004, 43(1):36-44.