Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways

Food and Chemical Toxicology

Volumn 66, Issue , 2014, Pages 245-253

  Fernández Millán, Elisa ^a   Ramos, Sonia ^b   Alvarez, Carmen ^a,c   Bravo, Laura ^b   Goya, Luis ^b   Martín, María Ángeles ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTE OF FOOD SCIENCE   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Dietary polyphenols; INS 1E beta cells; Oxidative stress; Type 2 diabetes mellitus

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; 3 HYDROXYPHENYLPROPIONIC ACID; 3,4 DIHYDROXYPHENYLACETIC ACID; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; UNCLASSIFIED DRUG; GLUCOSE; INSULIN; PHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE;

ANIMAL CELL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL FUNCTION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PANCREAS ISLET; SECRETION (PROCESS); TOXICITY;

ANIMALS; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; PHENOLS; PROTEIN KINASE C; RATS; REACTIVE OXYGEN SPECIES; TERT-BUTYLHYDROPEROXIDE;

EID: 84896709399     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.01.044     Document Type: Article

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