AMP-activated kinase relaxes agonist induced contractions in the mouse aorta via effects on PKC signaling and inhibits NO-induced relaxation

European Journal of Pharmacology

Volumn 695, Issue 1-3, 2012, Pages 88-95

  Davis, Benjamin ^a   Rahman, Awahan ^a   Arner, Anders ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

AICAR; AMPK; Mouse; NO; PKC; SNP

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE 1 BETA D RIBOFURANOSIDE; ACETYLCHOLINE; ADENOSINE MONOPHOSPHATE ACTIVATED KINASE ALPHA 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INDOMETACIN; MESSENGER RNA; MUSCLE RELAXANT AGENT; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA CONSTRICTION; ARTERY COMPLIANCE; ARTERY RESISTANCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE RELAXATION;

ADRENERGIC AGONISTS; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MUSCARINIC AGONISTS; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE; PHENYLEPHRINE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RIBONUCLEOTIDES; RNA, MESSENGER; SIGNAL TRANSDUCTION; URINARY BLADDER;

EID: 84867580539     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.025     Document Type: Article

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