Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Hoover, Wyn C ^a   Zhang, Wenwu ^a   Xue, Zhidong ^a   Gao, Huanling ^a   Chernoff, Jonathan ^b   Clapp, D Wade ^a   Gunst, Susan J ^a   Tepper, Robert S ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; P21 ACTIVATED KINASE; PHOSPHOTRANSFERASE INHIBITOR; SEROTONIN;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BREATHING MUSCLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; FUNCTIONAL ASSESSMENT; GENE; GENE DELETION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG FUNCTION; LUNG PARENCHYMA; MORPHOLOGY; MOUSE; MUSCLE EXCITATION; MUSCLE TISSUE; NONHUMAN; PAK1 GENE; SMOOTH MUSCLE CONTRACTILITY; TRACHEA MUSCLE; WILD TYPE;

ACETYLCHOLINE; ADMINISTRATION, INHALATION; ADMINISTRATION, INTRAVENOUS; ANIMALS; BRONCHIAL HYPERREACTIVITY; DISEASE MODELS, ANIMAL; DISULFIDES; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; LUNG; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH; NAPHTHOLS; P21-ACTIVATED KINASES; TRACHEA;

EID: 84864981988     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042601     Document Type: Article

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