-
1
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
The Huntington's Disease Collaborative Research Group
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group, 1993. Cell 72, 971-983
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
2
-
-
0037002444
-
Huntington's disease of the endocrine pancreas: Insulin deficiency and diabetes mellitus due to impaired insulin gene expression
-
DOI 10.1006/nbdi.2002.0562
-
O.A. Andreassen, A. Dedeoglu, V. Stanojevic, D.B. Hughes, S.E. Browne, C.A. Leech, R.J. Ferrante, J.F. Habener, M.F. Beal, and M.K. Thomas Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression Neurobiol. Dis. 11 2002 410 424 (Pubitemid 36269126)
-
(2002)
Neurobiology of Disease
, vol.11
, Issue.3
, pp. 410-424
-
-
Andreassen, O.A.1
Dedeoglu, A.2
Stanojevic, V.3
Hughes, D.B.4
Browne, S.E.5
Leech, C.A.6
Ferrante, R.J.7
Habener, J.F.8
Beal, M.F.9
Thomas, M.K.10
-
3
-
-
0031916812
-
Complex I defect in muscle from patients with Huntington's disease
-
DOI 10.1002/ana.410430321
-
J. Arenas, Y. Campos, R. Ribacoba, M.A. Martín, J.C. Rubio, P. Ablanedo, and A. Cabello Complex I defect in muscle from patients with Huntington's disease Ann. Neurol. 43 1998 397 400 (Pubitemid 28113606)
-
(1998)
Annals of Neurology
, vol.43
, Issue.3
, pp. 397-400
-
-
Arenas, J.1
Campos, Y.2
Ribacoba, R.3
Martin, M.A.4
Rubio, J.C.5
Ablanedo, P.6
Cabello, A.7
-
4
-
-
56149125562
-
Weight loss in Huntington disease increases with higher CAG repeat number
-
N.A. Aziz, J.M.M. van der Burg, G.B. Landwehrmeyer, P. Brundin, T. Stijnen, and R.A.C. Roos Weight loss in Huntington disease increases with higher CAG repeat number Neurology 71 2008 1506 1513
-
(2008)
Neurology
, vol.71
, pp. 1506-1513
-
-
Aziz, N.A.1
Van Der Burg, J.M.M.2
Landwehrmeyer, G.B.3
Brundin, P.4
Stijnen, T.5
Roos, R.A.C.6
-
5
-
-
33745392939
-
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin
-
DOI 10.1091/mbc.E05-07-0607
-
A. Benchoua, Y. Trioulier, D. Zala, M.-C. Gaillard, N. Lefort, N. Dufour, F. Saudou, J.-M. Elalouf, E. Hirsch, P. Hantraye, N. Déglon, and E. Brouillet Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin Mol. Biol. Cell 17 2006 1652 1663 (Pubitemid 44011583)
-
(2006)
Molecular Biology of the Cell
, vol.17
, Issue.4
, pp. 1652-1663
-
-
Benchoua, A.1
Trioulier, Y.2
Zala, D.3
Gaillard, M.-C.4
Lefort, N.5
Dufour, N.6
Saudou, F.7
Elalouf, J.-M.8
Hirsch, E.9
Hantraye, P.10
Deglon, N.11
Brouillet, E.12
-
6
-
-
20044392282
-
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient β-cell mass and exocytosis
-
DOI 10.1093/hmg/ddi053
-
M. Björkqvist, M. Fex, E. Renström, N. Wierup, A. Petersén, J. Gil, K. Bacos, N. Popovic, J.-Y. Li, F. Sundler, P. Brundin, and H. Mulder The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis Hum. Mol. Genet. 14 2005 565 574 (Pubitemid 40309582)
-
(2005)
Human Molecular Genetics
, vol.14
, Issue.5
, pp. 565-574
-
-
Bjorkqvist, M.1
Fex, M.2
Renstrom, E.3
Wierup, N.4
Petersen, A.5
Gil, J.6
Bacos, K.7
Popovic, N.8
Li, J.-Y.9
Sundler, F.10
Brundin, P.11
Mulder, H.12
-
7
-
-
33745210300
-
Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease
-
DOI 10.1093/hmg/ddl094
-
M. Björkqvist, A. Petersén, K. Bacos, J. Isaacs, P. Norlén, J. Gil, N. Popovic, F. Sundler, G.P. Bates, S.J. Tabrizi, P. Brundin, and H. Mulder Progressive alterations in the hypothalamic-pituitary- adrenal axis in the R6/2 transgenic mouse model of Huntington's disease Hum. Mol. Genet. 15 2006 1713 1721 (Pubitemid 43904837)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.10
, pp. 1713-1721
-
-
Bjorkqvist, M.1
Petersen, A.2
Bacos, K.3
Isaacs, J.4
Norlen, P.5
Gil, J.6
Popovic, N.7
Sundler, F.8
Bates, G.P.9
Tabrizi, S.J.10
Brundin, P.11
Mulder, H.12
-
8
-
-
55249118839
-
Increased contractility to noradrenaline and normal endothelial function in mesenteric small arteries from the Goto-Kakizaki rat model of type 2 diabetes
-
E. Brondum, H. Kold-Petersen, H. Nilsson, A. Flyvbjerg, and C. Aalkjaer Increased contractility to noradrenaline and normal endothelial function in mesenteric small arteries from the Goto-Kakizaki rat model of type 2 diabetes J. Physiol Sci. 58 2008 333 339
-
(2008)
J. Physiol Sci.
, vol.58
, pp. 333-339
-
-
Brondum, E.1
Kold-Petersen, H.2
Nilsson, H.3
Flyvbjerg, A.4
Aalkjaer, C.5
-
9
-
-
57649187103
-
Mitochondria and Huntington's disease pathogenesis: Insight from genetic and chemical models
-
S.E. Browne Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models Ann. N.Y. Acad. Sci. 1147 2008 358 382
-
(2008)
Ann. N.Y. Acad. Sci.
, vol.1147
, pp. 358-382
-
-
Browne, S.E.1
-
10
-
-
58249110567
-
Cardiovascular actions of neurotrophins
-
A. Caporali, and C. Emanueli Cardiovascular actions of neurotrophins Physiol. Rev. 89 2009 279 308
-
(2009)
Physiol. Rev.
, vol.89
, pp. 279-308
-
-
Caporali, A.1
Emanueli, C.2
-
11
-
-
0034143642
-
Increased CBF velocity during word fluency in Huntington's disease patients
-
DOI 10.1016/S0278-5846(99)00099-8, PII S0278584699000998
-
A.W. Deckel, and D. Cohen Increased CBF velocity during word fluency in Huntington's disease patients Prog. Neuro-Psychopharmacol. Biol. Psychiatry 24 2000 193 206 (Pubitemid 30159529)
-
(2000)
Progress in Neuro-Psychopharmacology and Biological Psychiatry
, vol.24
, Issue.2
, pp. 193-206
-
-
Deckel, A.W.1
Cohen, D.2
-
12
-
-
0035900181
-
Reduced activity and protein expression of NOS in R6/2 HD transgenic mice: Effects of L-NAME on symptom progression
-
DOI 10.1016/S0006-8993(01)03000-1, PII S0006899301030001
-
A.W. Deckel, A. Gordinier, D. Nuttal, V. Tang, C. Kuwada, R. Freitas, and K.A. Gary Reduced activity and protein expression of NOS in R6/2 HD transgenic mice: effects of l-NAME on symptom progression Brain Res. 919 2001 70 81 (Pubitemid 33016591)
-
(2001)
Brain Research
, vol.919
, Issue.1
, pp. 70-81
-
-
Deckel, A.W.1
Gordinier, A.2
Nuttal, D.3
Tang, V.4
Kuwada, C.5
Freitas, R.6
Gary, K.A.7
-
13
-
-
77956266974
-
Endothelium-derived vasoactive factors and hypertension: Possible roles in pathogenesis and as treatment targets
-
M. Félétou, R. Köhler, and P.M. Vanhoutte Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets Curr. Hypertens. Rep. 12 2010 267 275
-
(2010)
Curr. Hypertens. Rep.
, vol.12
, pp. 267-275
-
-
Félétou, M.1
Köhler, R.2
Vanhoutte, P.M.3
-
15
-
-
10844288015
-
Early sympathetic hyperactivity in Huntington's disease
-
DOI 10.1111/j.1468-1331.2004.00894.x
-
J. Kobal, B. Meglic, A. Mesec, and B. Peterlin Early sympathetic hyperactivity in Huntington's disease Eur. J. Neurol. 11 2004 842 848 (Pubitemid 39665063)
-
(2004)
European Journal of Neurology
, vol.11
, Issue.12
, pp. 842-848
-
-
Kobal, J.1
Meglic, B.2
Mesec, A.3
Peterlin, B.4
-
16
-
-
0041903805
-
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
-
DOI 10.1038/ng1211
-
D. Lambrechts, E. Storkebaum, M. Morimoto, J. Del-Favero, F. Desmet, S.L. Marklund, S. Wyns, V. Thijs, J. Andersson, I. van Marion, A. Al-Chalabi, S. Bornes, R. Musson, V. Hansen, L. Beckman, R. Adolfsson, H.S. Pall, H. Prats, S. Vermeire, P. Rutgeerts, S. Katayama, T. Awata, N. Leigh, L. Lang-Lazdunski, M. Dewerchin, C. Shaw, L. Moons, R. Vlietinck, K.E. Morrison, W. Robberecht, C. Van Broeckhoven, D. Collen, P.M. Andersen, and P. Carmeliet VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death Nat. Genet. 34 2003 383 394 (Pubitemid 36935331)
-
(2003)
Nature Genetics
, vol.34
, Issue.4
, pp. 383-394
-
-
Lambrechts, D.1
Storkebaum, E.2
Morimoto, M.3
Del-Favero, J.4
Desmet, F.5
Marklund, S.L.6
Wyns, S.7
Thijs, V.8
Andersson, J.9
Van Marion, I.10
Al-Chalabi, A.11
Bornes, S.12
Musson, R.13
Hansen, V.14
Beckman, L.15
Adolfsson, R.16
Pall, H.S.17
Prats, H.18
Vermeire, S.19
Rutgeerts, P.20
Katayama, S.21
Awata, T.22
Leigh, N.23
Lang-Lazdunski, L.24
Dewerchin, M.25
Shaw, C.26
Moons, L.27
Vlietinck, R.28
Morrison, K.E.29
Robberecht, W.30
Van Broeckhoven, C.31
Collen, D.32
Andersen, P.M.33
Carmeliet, P.34
more..
-
17
-
-
16044373842
-
Exon I of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
DOI 10.1016/S0092-8674(00)81369-0
-
L. Mangiarini, K. Sathasivam, M. Seller, B. Cozens, A. Harper, C. Hetherington, M. Lawton, Y. Trottier, H. Lehrach, S.W. Davies, and G.P. Bates Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice Cell 87 1996 493 506 (Pubitemid 26374323)
-
(1996)
Cell
, vol.87
, Issue.3
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
Bates, G.P.11
-
18
-
-
33846369453
-
Cardiac dysfunction in the R6/2 mouse model of Huntington's disease
-
DOI 10.1016/j.nbd.2006.09.016, PII S0969996106002415
-
M.J. Mihm, D.M. Amann, B.L. Schanbacher, R.A. Altschuld, J.A. Bauer, and K.R. Hoyt Cardiac dysfunction in the R6/2 mouse model of Huntington's disease Neurobiol. Dis. 25 2007 297 308 (Pubitemid 46127844)
-
(2007)
Neurobiology of Disease
, vol.25
, Issue.2
, pp. 297-308
-
-
Mihm, M.J.1
Amann, D.M.2
Schanbacher, B.L.3
Altschuld, R.A.4
Bauer, J.A.5
Hoyt, K.R.6
-
19
-
-
77649153747
-
Impairment of α1-adrenoceptor-mediated contractile activity in caudal arterial smooth muscle from type 2 diabetic Goto-Kakizaki rats
-
M. Mita, T. Kuramoto, K. Ito, N. Toguchi-Senrui, S. Hishinuma, M.P. Walsh, and M. Shoji Impairment of α1-adrenoceptor-mediated contractile activity in caudal arterial smooth muscle from type 2 diabetic Goto-Kakizaki rats Clin. Exp. Pharmacol. Physiol. 37 2010 350 357
-
(2010)
Clin. Exp. Pharmacol. Physiol.
, vol.37
, pp. 350-357
-
-
Mita, M.1
Kuramoto, T.2
Ito, K.3
Toguchi-Senrui, N.4
Hishinuma, S.5
Walsh, M.P.6
Shoji, M.7
-
20
-
-
0036327065
-
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
-
DOI 10.1038/nn884
-
A.V. Panov, C.-A. Gutekunst, B.R. Leavitt, M.R. Hayden, J.R. Burke, W.J. Strittmatter, and J.T. Greenamyre Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines Nat. Neurosci. 5 2002 731 736 (Pubitemid 34827590)
-
(2002)
Nature Neuroscience
, vol.5
, Issue.8
, pp. 731-736
-
-
Panov, A.V.1
Gutekunst, C.-A.2
Leavitt, B.R.3
Hayden, M.R.4
Burke, J.R.5
Strittmatter, W.J.6
Greenamyre, J.T.7
-
21
-
-
44449104300
-
Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure
-
DOI 10.1161/CIRCULATIONAHA.107.750232, PII 0000301720080527000007
-
J.S. Pattison, A. Sanbe, A. Maloyan, H. Osinska, R. Klevitsky, and J. Robbins Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure Circulation 117 2008 2743 2751 (Pubitemid 351770455)
-
(2008)
Circulation
, vol.117
, Issue.21
, pp. 2743-2751
-
-
Pattison, J.S.1
Sanbe, A.2
Maloyan, A.3
Osinska, H.4
Klevitsky, R.5
Robbins, J.6
-
22
-
-
61849093278
-
Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models
-
J. Phan, M.A. Hickey, P. Zhang, M.-F. Chesselet, and K. Reue Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models Hum. Mol. Genet. 18 2009 1006 1016
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 1006-1016
-
-
Phan, J.1
Hickey, M.A.2
Zhang, P.3
Chesselet, M.-F.4
Reue, K.5
-
23
-
-
58149232354
-
The role of caveolin-1 in cardiovascular regulation
-
A. Rahman, and K. Swärd The role of caveolin-1 in cardiovascular regulation Acta Physiol. (Oxf) 195 2009 231 245
-
(2009)
Acta Physiol. (Oxf)
, vol.195
, pp. 231-245
-
-
Rahman, A.1
Swärd, K.2
-
24
-
-
67349247037
-
Mitochondrial structural and functional dynamics in Huntington's disease
-
P.H. Reddy, P. Mao, and M. Manczak Mitochondrial structural and functional dynamics in Huntington's disease Brain Res. Rev. 61 2009 33 48
-
(2009)
Brain Res. Rev.
, vol.61
, pp. 33-48
-
-
Reddy, P.H.1
Mao, P.2
Manczak, M.3
-
25
-
-
70350018469
-
The neurovascular link in health and disease: An update
-
I. Segura, F. De Smet, P.J. Hohensinner, C. Ruiz de Almodovar, and P. Carmeliet The neurovascular link in health and disease: an update Trends. Mol. Med. 15 2009 439 451
-
(2009)
Trends. Mol. Med.
, vol.15
, pp. 439-451
-
-
Segura, I.1
De Smet, F.2
Hohensinner, P.J.3
Ruiz De Almodovar, C.4
Carmeliet, P.5
-
26
-
-
0028043535
-
Signal transduction and regulation in smooth muscle
-
DOI 10.1038/372231a0
-
A.P. Somlyo, and A.V. Somlyo Signal transduction and regulation in smooth muscle Nature 372 1994 231 236 (Pubitemid 24352442)
-
(1994)
Nature
, vol.372
, Issue.6503
, pp. 231-236
-
-
Somlyo, A.P.1
Somlyo, A.V.2
-
27
-
-
0027432418
-
Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues
-
DOI 10.1038/ng1193-259
-
T.V. Strong, D.A. Tagle, J.M. Valdes, L.W. Elmer, K. Boehm, M. Swaroop, K.W. Kaatz, F.S. Collins, and R.L. Albin Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues Nat. Genet. 5 1993 259 265 (Pubitemid 23330389)
-
(1993)
Nature Genetics
, vol.5
, Issue.3
, pp. 259-265
-
-
Strong, T.V.1
Tagle, D.A.2
Valdes, J.M.3
Elmer, L.W.4
Boehm, K.5
Swaroop, M.6
Kaatz, K.W.7
Collins, F.S.8
Albin, R.L.9
-
28
-
-
0037134406
-
i in rat tail artery
-
DOI 10.1161/01.RES.0000015214.40360.84
-
K. Swärd, K. Dreja, A. Lindqvist, E. Persson, and P. Hellstrand Influence of mitochondrial inhibition on global and local [Ca(2+)](I) in rat tail artery Circ. Res. 90 2002 792 799 (Pubitemid 34633895)
-
(2002)
Circulation Research
, vol.90
, Issue.7
, pp. 792-799
-
-
Sward, K.1
Dreja, K.2
Lindqvist, A.3
Persson, E.4
Hellstrand, P.5
-
29
-
-
68249113963
-
Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: Cross-sectional analysis of baseline data
-
S.J. Tabrizi, D.R. Langbehn, B.R. Leavitt, R.A. Roos, A. Durr, D. Craufurd, C. Kennard, S.L. Hicks, N.C. Fox, R.I. Scahill, B. Borowsky, A.J. Tobin, H.D. Rosas, H. Johnson, R. Reilmann, B. Landwehrmeyer, and J.C. Stout Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data Lancet Neurol. 8 2009 791 801
-
(2009)
Lancet Neurol.
, vol.8
, pp. 791-801
-
-
Tabrizi, S.J.1
Langbehn, D.R.2
Leavitt, B.R.3
Roos, R.A.4
Durr, A.5
Craufurd, D.6
Kennard, C.7
Hicks, S.L.8
Fox, N.C.9
Scahill, R.I.10
Borowsky, B.11
Tobin, A.J.12
Rosas, H.D.13
Johnson, H.14
Reilmann, R.15
Landwehrmeyer, B.16
Stout, J.C.17
-
30
-
-
0032102920
-
Hypoxia and smooth muscle function: Key regulatory events during metabolic stress
-
DOI 10.1111/j.1469-7793.1998.315bn.x
-
M.J. Taggart, and S. Wray Hypoxia and smooth muscle function: key regulatory events during metabolic stress J. Physiol. (Lond.) 509 Pt 2 1998 315 325 (Pubitemid 28286991)
-
(1998)
Journal of Physiology
, vol.509
, Issue.2
, pp. 315-325
-
-
Taggart, M.J.1
Wray, S.2
-
31
-
-
33845357970
-
Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo
-
DOI 10.1093/hmg/ddl434
-
E. Trushina, R.D. Singh, R.B. Dyer, S. Cao, V.H. Shah, R.G. Parton, R.E. Pagano, and C.T. McMurray Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo Hum. Mol. Genet. 15 2006 3578 3591 (Pubitemid 44884124)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.24
, pp. 3578-3591
-
-
Trushina, E.1
Singh, R.D.2
Dyer, R.B.3
Cao, S.4
Shah, V.H.5
Parton, R.G.6
Pagano, R.E.7
McMurray, C.T.8
-
32
-
-
36549050391
-
Increased metabolism in the R6/2 mouse model of Huntington's disease
-
DOI 10.1016/j.nbd.2007.07.029, PII S0969996107001830
-
J.M.M. van der Burg, K. Bacos, N.I. Wood, A. Lindqvist, N. Wierup, B. Woodman, J.I. Wamsteeker, R. Smith, T. Deierborg, M.J. Kuhar, G.P. Bates, H. Mulder, C. Erlanson-Albertsson, A.J. Morton, P. Brundin, A. Petersén, and M. Björkqvist Increased metabolism in the R6/2 mouse model of Huntington's disease Neurobiol. Dis. 29 2008 41 51 (Pubitemid 350180481)
-
(2008)
Neurobiology of Disease
, vol.29
, Issue.1
, pp. 41-51
-
-
Van Der Burg, J.M.M.1
Bacos, K.2
Wood, N.I.3
Lindqvist, A.4
Wierup, N.5
Woodman, B.6
Wamsteeker, J.I.7
Smith, R.8
Deierborg, T.9
Kuhar, M.J.10
Bates, G.P.11
Mulder, H.12
Erlanson-Albertsson, C.13
Morton, A.J.14
Brundin, P.15
Petersen, A.16
Bjorkqvist, M.17
-
33
-
-
67650095269
-
Beyond the brain: Widespread pathology in Huntington's disease
-
J.M.M. van der Burg, M. Björkqvist, and P. Brundin Beyond the brain: widespread pathology in Huntington's disease Lancet Neurol. 8 2009 765 774
-
(2009)
Lancet Neurol.
, vol.8
, pp. 765-774
-
-
Van Der Burg, J.M.M.1
Björkqvist, M.2
Brundin, P.3
-
34
-
-
0022395922
-
Neuropathological classification of Huntington's disease
-
J.P. Vonsattel, R.H. Myers, T.J. Stevens, R.J. Ferrante, E.D. Bird, and E.P. Richardson Jr Neuropathological classification of Huntington's disease J. Neuropathol. Exp. Neurol. 44 1985 559 577 (Pubitemid 16196286)
-
(1985)
Journal of Neuropathology and Experimental Neurology
, vol.44
, Issue.6
, pp. 559-577
-
-
Vonsattel, J.-P.1
Myers, R.H.2
Stevens, T.J.3
|