Invited review: Molecular mechanisms of phenotypic plasticity in smooth muscle cells

Journal of Applied Physiology

Volumn 90, Issue 1, 2001, Pages 358-368

  Halayko, A J ^a   Solway, J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Cytoskeleton; Gene transcription; Heterogeneity; Phenotype; Rho GTPase; Serum response factor

Indexed keywords

CONTRACTILE PROTEIN; CYTOSKELETON PROTEIN; RECEPTOR PROTEIN; STRUCTURAL PROTEIN; TRANSCRIPTION FACTOR;

CYTOLOGY; GASTROINTESTINAL DISEASE; GENE EXPRESSION; GENETIC CODE; HUMAN; MOLECULAR BIOLOGY; MORPHOLOGY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; VASCULAR DISEASE; ANIMAL; GENETIC MARKER; GENETIC TRANSCRIPTION; HEART PAPILLARY MUSCLE; MUSCLE CONTRACTION; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; GENETIC MARKERS; HUMANS; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCLE, SMOOTH; PAPILLARY MUSCLES; PHENOTYPE; TRANSCRIPTION, GENETIC;

EID: 0035164457     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.90.1.358     Document Type: Review

References (167)

1. Positive and negative acting Krüppel-like transcription factors bind a transforming growth factor β control element required for expression of the smooth muscle cell differentiation marker SM22 in vivo
2. Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia
3. Effectors for the Rho GTPases
4. Entry and distribution of fluorescent antiproliferative heparin derivatives into rat vascular smooth muscle cells: Comparison between heparin-sensitive and heparin-resistant cultures
5. Organization and myogenic restricted expression of the murine serum response factor gene. A role for autoregulation
6. Evidence for cultured human vascular smooth muscle cell heterogeneity: Isolation of clonal cells and study of their growth characteristics
7. Synthesis and expression of smooth muscle phenotype markers in primary culture of rabbit aortic smooth muscle cells: Influence of seeding density and media and relation to cell contractility
8. Elements of the smooth muscle α-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation
9. A retinoic acid-induced clonal cell line derived from multipotential P19 embryonal carcinoma cells expresses smooth muscle characteristics
10. Phenotypic heterogeneity of rat arterial smooth muscle cell clones. Implications for the development of experimental intimal thickening
11. Tissue-specific expression of profilin
12. Signalling pathways: Jack of all cascades
13. Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor
14. Chemical stimuli of the hypertrophic response in smooth muscle
15. Smooth muscle phenotypic changes in arterial wall homeostasis. Implications for pathogenesis of atherosclerosis
16. The smooth muscle cell in culture
17. Mechanical strain memory in airway smooth muscle
18. Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase
19. Relevance of normalization and classification by size to topographical differences in bronchial smooth muscle contractile response
20. Assembly of smooth muscle myosin into side-polar filaments
21. Avian serum response factor expression restricted primarily to muscle cell lineages is required for α-actin gene transcription
22. MHox: A mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer
23. Regional heterogeneity of arterial structural changes
24. Expression and localization of tropoelastin mRNA in the developing bovine pulmonary artery is dependent on vascular cell phenotype
25. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study
26. Expression of smooth muscle myosin light chain 17 and unloaded shortening in single smooth muscle cells
27. Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties
28. Reversible disaggregation of myofilaments in vertebrate smooth muscle
29. Myocyte enhancer binding factor- 2 expression and activity in vascular smooth muscle cells. Association with the activated phenotype
30. Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities
31. Smooth muscle cell heterogeneity in pulmonary and systemic vessels. Importance in vascular disease
32. Phenotypic changes of human smooth muscle cells during development: Late expression of heavy caldesmon and calponin
33. Mutagenesis analysis of SM22 function: Characterization of actin binding domain and modulation of actin binding by protein kinase C phosphorylation
34. Vascular smooth muscle cells differ from other smooth muscle cells: Predominance of vimentin filaments and a specific alpha-type actin
35. Density of myosin filaments in the rat anococcygeus muscle, at rest and in contraction
36. Calponin and SM 22 isoforms in avian and mammalian smooth muscle. Absence of phosphorylation in vivo
37. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma
38. Modulation of human aorta smooth muscle cell phenotype: A study of muscle-specific variants of vinculin, caldesmon, and actin expression
39. Polarized light microscopy of the smooth muscle anococcygeus of the rat
40. Mechanical properties of smooth muscle. I. Length-tension and force-velocity relations
41. Mechanisms for the mechanical plasticity of tracheal smooth muscle
42. The contractile apparatus and mechanical properties of airway smooth muscle
43. Divergent differentiation paths in airway smooth muscle culture: Induction of functionally contractile myocytes
44. Proliferation of canine airway smooth muscle cells: Characterization of subpopulations by sensitivity to heparin inhibition
45. Characterization of molecular determinants of smooth muscle cell heterogeneity
46. Markers of airway smooth muscle phenotype
47. Potential role for phenotypic modulation of bronchial smooth muscle cells in chronic asthma
48. Rho GTPases and the actin cytoskeleton
49. Length versus active force relationship in single isolated smooth muscle cells
50. Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox
51. Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase
52. Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells
53. Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells
54. Length-tension relationship of smooth muscle of the hog carotid artery
55. Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho
56. Differential effects of extracellular matrix proteins on human airway smooth muscle cell proliferation and phenotype
57. 3-D image reconstruction of reconstituted smooth muscle thin filaments containing calponin: Visualization of interactions between F-actin and calponin
58. Epithelial-mesenchymal interactions in the pathogenesis of asthma
59. Differentiated vascular myocytes: Are they involved in neointimal formation?
60. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase
61. Identification of functional promoter elements in the rabbit smooth muscle myosin heavy chain gene
62. A novel smooth muscle-specific enhancer regulates transcription of the smooth muscle myosin heavy chain gene in vascular smooth muscle cells
63. Polymerization of vertebrate non-muscle and smooth muscle myosins
64. A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages
65. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
66. Regional contractile responses in pulmonary artery to α- and β-adrenoreceptor agonists
67. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
68. Identification of two types of smooth muscle cells from rabbit urinary bladder
69. Diversity in smooth muscle thin filament composition
70. Heparin binding, internalization, and metabolism in vascular smooth muscle cells. I. Upregulation of heparin binding correlates with antiproliferative activity
71. Heparin binding, internalization, and metabolism in vascular smooth muscle cells. II. Degradation and secretion in sensitive and resistant cells
72. SM22 α, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis
73. Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes
74. Heterogeneous iso-actin gene expression in the adult rat gastrointestinal tract
75. Detection of two clusters of mechanical properties of smooth muscle along the airway tree
76. Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells
77. Immunocytochemical localization of caldesmon and calponin in chicken gizzard smooth muscle
78. Smooth muscle differentiation marker gene expression is regulated by rhoA-mediated actin polymerization
79. Smooth muscle α-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex
80. Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells
81. Smooth muscle-specific expression of the smooth muscle myosin heavy chain gene in transgenic mice requires 5′-flanking and first intronic DNA sequence
82. Smooth muscle cells isolated from the neointima after vascular injury exhibit altered responses to platelet-derived growth factor and other stimuli
83. Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury
84. Expression of smooth muscle myosin heavy chains and unloaded shortening in single smooth muscle cells
85. Actin polymerization stimulated by contractile activation regulates force development in canine tracheal smooth muscle
86. 2+-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle
87. Role of contractile protein activation in the length-dependent modulation of tracheal smooth muscle force
88. Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells
89. Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis
90. Heterogeneity of smooth muscle cells in embryonic human aorta
91. Smooth muscle cell markers in developing rat lung
92. Induction of M3 muscarinic receptor gene expression and acetylcholine responsiveness in cultured canine tracheal smooth muscle cells
93. Monoclonality of smooth muscle cells in human atherosclerosis
94. Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis
95. Cellular retinol-binding protein-1 is expressed by distinct subsets of rat arterial smooth muscle cells in vitro and in vivo
96. Different electrical responses to vasoactive agonists in morphologically distinct smooth muscle cell types
97. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimeric focal complexes associated with actin stress fibers, lamellipodia, and filopodia
98. Calponin is localised in both the contractile apparatus and the cytoskeleton of smooth muscle cells
99. Actin isoform compartments in chicken gizzard smooth muscle cells
100. Smooth muscle cell phenotype-dependent transcriptional regulation of the alpha-1 integrin gene
101. Heterogeneity of intermediate filament expression in vascular smooth muscle: A gradient in desmin positive cells from the rat aortic arch to the level of the arteria iliaca communis
102. Regulation of differentiation of vascular smooth muscle cells
103. Actin and actin-binding proteins. A critical evaluation of mechanisms and functions
104. Plasticity in canine airway smooth muscle
105. 2+ sensitive to voltage dependent
106. Cell elongation induces laminin α2 chain expression in mouse embryonic mesenchymal cells: Role in visceral myogenesis
107. Stress fibres take shape
108. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
109. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
110. RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation
111. Myosin isoform expression in smooth muscle cells during physiological and pathological vascular remodelling
112. Cellular distribution of smooth muscle actins during mammalian embryogenesis: Expression of the α-vascular but not the γ-enteric isoform in differentiating striated myocytes
113. Inhibition of CapZ during myofibrillogenesis alters assembly of actin filaments
114. Regulation of non-muscle myosin assembly by calmodulin-dependent light chain kinase
115. Laminin alpha1 chain synthesis in the mouse developing lung: Requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development
116. Response of arterial smooth muscle to length perturbation
117. Series-to-parallel transition in the filament lattice of airway smooth muscle
118. Smooth muscle cell heterogeneity: Patterns of gene expression in vascular smooth muscle cells in vitro and in vivo
119. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells
120. The smooth muscle α-actin gene promoter is differentially regulated in smooth muscle versus non-smooth muscle cells
121. The Schultz-Dale response of sensitized canine bronchial smooth muscle
122. Strain reorganizes focal adhesions and cytoskeleton in cultured airway smooth muscle cells
123. Strain increases airway smooth muscle contractile and cytoskeletal proteins in vitro
124. Regulation of myosin filament assembly by light-chain phosphorylation
125. Transcriptional regulation of smooth muscle-specific genes
126. Structure and expression of a smooth muscle cell-specific gene, SM22 α
127. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and nonmuscle myosin II
128. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics
129. Growth and differentiation of C2 myogenic cells are dependent on serum response factor
130. Innervation and function of the distal airways in the developing bronchial tree of fetal pig
131. Expression of the serum response factor gene is regulated by serum response factor binding sites
132. The new kid on the airway smooth muscle block: Plasticity theory and series-toparallel filament transition
133. Force-velocity characteristics of respiratory airway smooth muscle
134. M3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms
135. Length-dependent modulation of myosin phosphorylation and contractile force in coronary arterial smooth muscle
136. The 5′-flanking region of the human smooth muscle cell calponin gene contains a cis-acting domain for interaction with a methylated DNA-binding transcription repressor
137. Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle
138. The anti-cancer agent distamycin A displaces essential transcription factors and selectively inhibits myogenic differentiation
139. Fibronectin and the basement membrane components laminin and collagen type IV influence the phenotypic properties of subcultured rat aortic smooth muscle cells differently
140. Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells
141. Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-β
142. The serum response element
143. Filamentous smooth muscle myosin is regulated by phosphorylation
144. Assembly of smooth muscle myosin minifilaments: Effects of phosphorylation and nucleotide binding
145. 2+], myosin phosphorylation, and force in smooth muscle
146. Calcium sensitization of smooth muscle mediated by Rho-associated protein kinase in hypertension
147. Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells
148. Heterogeneity in vascular smooth muscle
149. Isolation of a morphologically and functionally distinct smooth muscle cell type from the intimal aspect of the normal rat aorta. Evidence for smooth muscle cell heterogeneity
150. Characterization and confocal imaging of calponin in gastrointestinal smooth muscle
151. Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle
152. Effect of chronic passive length change on airway smooth muscle length-tension relationship
153. Tyrosine phosphorylation of the dense plaque protein paxillin is regulated during smooth muscle contraction
154. Effect of muscle length on isometric stress and myosin light chain phosphorylation in gallbladder smooth muscle
155. FH proteins as cytoskeletal organizers
156. X-ray diffraction study on mammalian visceral smooth muscles in resting and activated states
157. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
158. Diversity of response in vascular smooth muscle cells to changes in oxygen tension
159. Approaches to the development of selective inhibitors of vascular smooth muscle cell proliferation
160. Identification of promoter elements involved in cell-specific regulation of rat smooth muscle myosin heavy chain gene transcription
161. The arterial medial cell, smooth muscle or multifunctional mesenchyme?
162. Hypoxia selectively induces proliferation in a specific subpopulation of smooth muscle cells in the bovine neonatal pulmonary arterial media
163. Polymerization of myosin on activation of rat anococcygeus smooth muscle
164. Myosin filament structure in vertebrate smooth muscle
165. Myosin isoforms and cell heterogeneity in vascular smooth muscle. I. Developing and adult bovine aorta
166. Sorting of murine vascular smooth muscle cells during wound healing in the chicken chorioallantoic membrane
167. Signal transduction and actin filament organization