Co-administration of betulinic acid and methamphetamine causes toxicity to dopaminergic and serotonergic nerve terminals in the striatum of late adolescent rats

Journal of Neurochemistry

Volumn 128, Issue 5, 2014, Pages 764-775

  Killinger, Bryan ^a   Shah, Mrudang ^a   Moszczynska, Anna ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

betulinic acid; methamphetamine; mitochondria; neurotoxicity; striatum

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; BETULIC ACID; CASPASE 3; COMPLEX I SUBUNIT NDUFS3; CYTOCHROME C; DOPAMINE; METHAMPHETAMINE; PARKIN; PROTEASOME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SEROTONIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRYPTOPHAN; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN LEVEL; BRAIN SYNAPTOSOME; CELL LEVEL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME DEGRADATION; IMMUNOREACTIVITY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; NERVE ENDING; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEFICIENCY; RAT; SEROTONINERGIC NERVE CELL;

RATTUS;

BETULINIC ACID; METHAMPHETAMINE; MITOCHONDRIA; NEUROTOXICITY; STRIATUM;

ANIMALS; ANTI-HIV AGENTS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CASPASE 3; CHYMOTRYPSIN; CYTOCHROMES C; DOPAMINE AGENTS; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; FEVER; MALE; METHAMPHETAMINE; MITOCHONDRIA; NEOSTRIATUM; NERVE ENDINGS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONERGIC NEURONS; SYNAPTOSOMES; TRITERPENES; UBIQUITIN-PROTEIN LIGASES;

EID: 84896703583     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12496     Document Type: Article

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