Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells

Biology Open

Volumn 2, Issue 3, 2013, Pages 295-305

  Suhane, Sonal ^a   Kanzaki, Hirotaka ^a   Arumugaswami, Vaithilingaraja ^a   Murali, Ramachandran ^a   Ramanujan, V Krishnan ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Aerobic glycolysis; Metabolic switch; Mitochondrial complex I; Mitochondrial dysfunction; NDUFS3; Reactive oxygen species

Indexed keywords

EID: 84965053068     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20133244     Document Type: Article

References (29)

1. Bellance, N., Lestienne, P. and Rossignol, R. (2009). Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis. Front. Biosci. 14, 4015-4034.
2. Brandon, M., Baldi, P. and Wallace, D. C. (2006). Mitochondrial mutations in cancer. Oncogene 25, 4647-4662.
3. Chen, Z., Lu, W., Garcia-Prieto, C. and Huang, P. (2007). The Warburg effect and its cancer therapeutic implications. J. Bioenerg. Biomembr. 39, 267-274.
4. Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L. and Cantley, L. C. (2008). The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233.
5. Fischman, A. J. (2008). PET imaging of brain tumors. Cancer Treat. Res. 143, 67-92.
6. Genova, M. L., Bovina, C., Marchetti, M., Pallotti, F., Tietz, C., Biagini, G., Pugnaloni, A., Viticchi, C., Gorini, A., Villa, R. F. et al. (1997). Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain nonsynaptic mitochondria of aged rats. FEBS Lett. 410, 467-469.
7. Gogvadze, V., Zhivotovsky, B. and Orrenius, S. (2010). The Warburg effect and mitochondrial stability in cancer cells. Mol. Aspects Med. 31, 60-74.
8. Hanahan, D. and Weinberg, R. A. (2000). The hallmarks of cancer. Cell 100, 57-70.
9. G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res. 22, 399-412.
10. Janssen, R. J., Nijtmans, L. G., van den Heuvel, L. P. and Smeitink, J. A. (2006). Mitochondrial complex I: structure, function and pathology. J. Inherit. Metab. Dis. 29, 499-515.
11. Koopman, W. J., Nijtmans, L. G., Dieteren, C. E., Roestenberg, P., Valsecchi, F., Smeitink, J. A. and Willems, P. H. (2010). Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid. Redox Signal. 12, 1431-1470.
12. Lu, W., Hu, Y., Chen, G., Chen, Z., Zhang, H., Wang, F., Feng, L., Pelicano, H., Wang, H., Keating, M. J. et al. (2012). Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol. 10, e1001326.
13. Mathupala, S. P., Ko, Y. H. and Pedersen, P. L. (2009). Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. Semin. Cancer Biol. 19, 17-24.
14. Nijtmans, L. G., Artal, S. M., Grivell, L. A. and Coates, P. J. (2002). The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease. Cell. Mol. Life Sci. 59, 143-155.
15. Pelicano, H., Lu, W., Zhou, Y., Zhang, W., Chen, Z., Hu, Y. and Huang, P. (2009). Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism. Cancer Res. 69, 2375-2383.
16. Ramanujan, V. K. and Herman, B. A. (2007). Aging process modulates nonlinear dynamics in liver cell metabolism. J. Biol. Chem. 282, 19217-19226.
17. Ramanujan, V. K. and Herman, B. A. (2008). Nonlinear scaling analysis of glucose metabolism in normal and cancer cells. J. Biomed. Opt. 13, 031219.
18. Ramanujan, V. K., Zhang, J. H., Biener, E. and Herman, B. (2005). Multiphoton fluorescence lifetime contrast in deep tissue imaging: prospects in redox imaging and disease diagnosis. J. Biomed. Opt. 10, 051407.
19. Ramanujan, V. K., Jo, J. A., Cantu, G. and Herman, B. A. (2008). Spatially resolved fluorescence lifetime mapping of enzyme kinetics in living cells. J. Microsc. 230, 329-338.
20. Semenza, G. L. (2007). HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J. Bioenerg. Biomembr. 39, 231-234.
21. Suhane, S. and Ramanujan, V. K. (2011). Thyroid hormone differentially modulates Warburg phenotype in breast cancer cells. Biochem. Biophys. Res. Commun. 414, 73-78.
22. Suhane, S., Berel, D. and Ramanujan, V. K. (2011). Biomarker signatures of mitochondrial NDUFS3 in invasive breast carcinoma. Biochem. Biophys. Res. Commun. 412, 590-595.
23. Tennant, D. A., Durán, R. V., Boulahbel, H. and Gottlieb, E. (2009). Metabolic transformation in cancer. Carcinogenesis 30, 1269-1280.
24. Unwin, R. D., Craven, R. A., Harnden, P., Hanrahan, S., Totty, N., Knowles, M., Eardley, I., Selby, P. J. and Banks, R. E. (2003). Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect. Proteomics 3, 1620-1632.
25. Vander Heiden, M. G., Cantley, L. C. and Thompson, C. B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033.
26. Vogel, R. O., Dieteren, C. E., van den Heuvel, L. P., Willems, P. H., Smeitink, J. A., Koopman, W. J. and Nijtmans, L. G. (2007). Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits. J. Biol. Chem. 282, 7582-7590.
27. Wallace, D. C. (1999). Mitochondrial diseases in man and mouse. Science 283, 1482-1488.
28. Wang, J., Bai, L., Li, J., Sun, C., Zhao, J., Cui, C., Han, K., Liu, Y., Zhuo, X., Wang, T. et al. (2009). Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart. Sci. China C Life Sci. 52, 1003-1010.
29. Warburg, O. (1956). On respiratory impairment in cancer cells. Science 124, 269-270.