High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus

Synapse

Volumn 60, Issue 7, 2006, Pages 521-532

  Bowyer, John F ^a,b   Ali, Syed ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b NCTR   (United States)

Author keywords

Blood brain barrier; Fluoro Jade C; Hippocampus; Methamphetamine; Neurodegeneration; Seizures

Indexed keywords

FLUORESCENT DYE; FLUORO JADE C; IMMUNOGLOBULIN G; METHAMPHETAMINE; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY TEMPERATURE; BRAIN DAMAGE; BRAIN REGION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG MEGADOSE; EPILEPTIC STATE; HIPPOCAMPUS; HISTOPATHOLOGY; HYPERTHERMIA; IMMUNOREACTIVITY; LEARNING DISORDER; LIMBIC CORTEX; MACROPHAGE; MALE; MEMORY DISORDER; MICROGLIA; MOUSE; NERVE CELL DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE; SINGLE DRUG DOSE;

AMPHETAMINE-RELATED DISORDERS; AMYGDALA; ANIMALS; BLOOD-BRAIN BARRIER; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBRAL ARTERIES; DISEASE MODELS, ANIMAL; FEVER; GLIOSIS; HIPPOCAMPUS; IMMUNOGLOBULIN G; MALE; METHAMPHETAMINE; MICE; MICE, INBRED C57BL; MICROGLIA; NERVE DEGENERATION; NEURONS; ORGANIC CHEMICALS; PHAGOCYTOSIS; PLANT LECTINS; SEIZURES;

EID: 33749561071     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20324     Document Type: Article

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