New betulinic acid derivatives as potent proteasome inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5944-5947

  Qian, Keduo ^a   Kim, Sang Yong ^a   Hung, Hsin Yi ^a   Huang, Li ^b   Chen, Chin Ho ^b   Lee, Kuo Hsiung ^a,c  

^a University of North Carolina   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Betulinic acid derivatives; Proteasome inhibitors

Indexed keywords

AROMATIC COMPOUND; BETULIC ACID; CHYMOTRYPSIN; LACTACYSTIN; PROTEASOME; PROTEASOME INHIBITOR;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; LIPOPHILICITY; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CHYMOTRYPSIN; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; INFLAMMATION; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 80052566948     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.072     Document Type: Article

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