Estrogen up-regulates MMP2/9 expression in endometrial epithelial cell via VEGF-ERK1/2 pathway

Asian Pacific Journal of Tropical Medicine

Volumn 6, Issue 10, 2013, Pages 826-830

  Shan, Bao ^a   Li, Wang ^a   Yang, Shu Ying ^a   Li, Zhuo Ri ^a  

^a Department of Gynaecology and Obstetrics of Hainan People's Hospital ^*  (China)

Author keywords

Dysfunctional uterine bleeding; ERK1 2 signal pathway; Estrogen; Matrix metalloproteinase 2 and 9; Primary uterine epithelial cells; Vascular endothelial growth factor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CELL PROTEIN; ESTROGEN; GELATINASE; GELATINASE A; GELATINASE B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; VASCULOTROPIN;

ANIMAL CELL; ANOVULATION; ANOVULATORY DYSFUNCTIONAL UTERINE BLEEDING; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOMETRIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GELATIN ZYMOGRAPHY ANALYSIS; HYDROLYSIS; MESSENGER RNA SYNTHESIS; METRORRHAGIA; NONHUMAN; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

DYSFUNCTIONAL UTERINE BLEEDING; ERK1/2 SIGNAL PATHWAY; ESTROGEN; MATRIX METALLOPROTEINASE 2 AND 9; PRIMARY UTERINE EPITHELIAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CELLS, CULTURED; ENDOMETRIUM; EPITHELIAL CELLS; ESTROGENS; FEMALE; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METRORRHAGIA; UP-REGULATION;

EID: 84880641241     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(13)60146-7     Document Type: Article

References (15)

1. Hansen K Dysfunctional uterine bleeding (DUB)-a term beyond its time. SD Med 2012, 65(10):379.
2. Pitkin J Dysfunctional uterine bleeding. BMJ 2007, 334(7603):1110-1111.
3. Thomas MC Treatment options for dysfunctional uterine bleeding. Nurse Pract 2011, 36(8):14-20.
4. Zhang X, Qi C, Lin J Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding. Fertil Steril 2010, 93(7):2362-2367.
5. Rodgers WH, Matrisian LM, Giudice LC, Dsupin B, Cannon P, Svitek C, et al. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest 1994, 94(3):946-953.
6. Lockwood CJ Mechanisms of normal and abnormal endometrial bleeding. Menopause 2011, 18(4):408-411.
7. Lee YL, Chan YL, Chow WN, Ng EH, Lee KF, Yeung WS, et al. Endocrine gland-derived vascular endothelial growth factor stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the mitogen-activated protein kinase but not through the Akt pathway. Fertil Steril 2009, 91(5 Suppl):2163-2171.
8. Adya R, Tan BK, Punn A, Chen J, Randeva HS Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res 2008, 78(2):356-365.
9. Yu CQ, Shi SF, Liu YH, Wang RX, Song YH, Yu J Primary culture and morphologic observation of eutopic and ectopic endometrial cells from patients with endometriosis. Zhong Xi Yi Jie He Xue Bao 2006, 4(2):189-193.
10. George SJ, Johnson JL In situ zymography. Methods Mol Biol 2010, 622:271-277.
11. Cairns RA, Khokha R, Hill RP Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med 2003, 3(7):659-671.
12. Ghajar CM, George SC, Putnam AJ Matrix metalloproteinase control of capillary morphogenesis. Crit Rev Eukaryot Gene Expr 2008, 18(3):251-278.
13. Yong VW, Zabad RK, Agrawal S, Goncalves Dasilva A, Metz LM Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators. J Neurol Sci 2007, 259(1-2):79-84.
14. Chakrabarti S, Patel KD Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res 2005, 31(6):599-621.
15. Hyder SM, Huang JC, Nawaz Z, Boettger-Tong H, Mäkelä S, Chiappetta C, et al. Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environ Health Perspect 2000, 108(Suppl 5):785-790.