Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Fernandez Ruiz, Rebeca ^a,b   Vieira, Elaine ^a,b   Garcia Roves, Pablo M ^a,b   Gomis, Ramon ^a,b,c,d  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE 1B; STAT3 PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL LOSS; CELL PROLIFERATION; CELL VOLUME; CONTROLLED STUDY; ENZYME ACTIVITY; IN VIVO STUDY; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; APOPTOSIS; CELL COUNT; CELL LINE; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STREPTOZOCIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84896533846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090344     Document Type: Article

References (46)

1. Lebovitz HE (2001) Insulin resistance: definition and consequences. Exp Clin Endocrinol Diabetes 109 Suppl 2: S135-148. (Pubitemid 32577577)
2. Benito M (2011) Tissue-specificity of insulin action and resistance. Arch Physiol Biochem 117: 96-104.
3. Henquin JC, Cerasi E, Efendic S, Steiner DF, Boitard C (2008) Pancreatic betacell mass or beta-cell function? That is the question! Diabetes Obes Metab 10 Suppl 4: 1-4.
4. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, et al. (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110. (Pubitemid 36042113)
5. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, et al. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286: E41-49. (Pubitemid 38036608)
6. Ueki K, Okada T, Hu J, Liew CW, Assmann A, et al. (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 38: 583-588.
7. Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96. (Pubitemid 43278292)
8. Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, et al. (2007) Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem 282: 23829-23840. (Pubitemid 47328016)
9. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, et al. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283: 1544-1548.
10. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, et al. (2000) Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20: 5479-5489. (Pubitemid 30482885)
11. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, et al. (2006) Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12: 917-924. (Pubitemid 44175143)
12. Owen C, Czopek A, Agouni A, Grant L, Judson R, et al. (2012) Adipocytespecific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One 7: e32700.
13. Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, et al. (2009) Liverspecific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes 58: 590-599.
14. Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, et al. (2007) Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol 27: 7727-7734. (Pubitemid 350033677)
15. Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, et al. (2004) Isletsparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes 53: 61-66. (Pubitemid 38044698)
16. Gonzalez-Rodriguez A, Mas-Gutierrez JA, Mirasierra M, Fernandez-Perez A, Lee YJ, et al. (2012) Essential role of protein tyrosine phosphatase 1B in obesityinduced inflammation and peripheral insulin resistance during aging. Aging Cell 11: 284-296.
17. Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, et al. (1990) Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127: 126-132. (Pubitemid 20228111)
18. Gonzalez-Rodriguez A, Mas Gutierrez JA, Sanz-Gonzalez S, Ros M, Burks DJ, et al. (2010) Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. Diabetes 59: 588-599.
19. Casas S, Novials A, Reimann F, Gomis R, Gribble FM (2008) Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia 51: 2252-2262.
20. Altirriba J, Gasa R, Casas S, Ramirez-Bajo MJ, Ros S, et al. (2010) The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker. Diabetologia 53: 1406-1414.
21. Bonner-Weir S (2001) beta-cell turnover: its assessment and implications. Diabetes 50 Suppl 1: S20-24. (Pubitemid 32148210)
22. Avruch J (1998) Insulin signal transduction through protein kinase cascades. Mol Cell Biochem 182: 31-48. (Pubitemid 28181646)
23. Mashili F, Chibalin AV, Krook A, Zierath JR (2013) Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes 62: 457-465.
24. Gonzalez-Rodriguez A, Escribano O, Alba J, Rondinone CM, Benito M, et al. (2007) Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes. J Cell Physiol 212: 76-88. (Pubitemid 46867589)
25. Zhang J, Zhang N, Liu M, Li X, Zhou L, et al. (2012) Disruption of growth factor receptor-binding protein 10 in the pancreas enhances beta-cell proliferation and protects mice from streptozotocin-induced beta-cell apoptosis. Diabetes 61: 3189-3198.
26. Popov D (2011) Novel protein tyrosine phosphatase 1B inhibitors: interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control. Biochem Biophys Res Commun 410: 377-381.
27. Tsou RC, Bence KK (2012) Central regulation of metabolism by protein tyrosine phosphatases. Front Neurosci 6: 192.
28. Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, et al. (2010) PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J Clin Invest 120: 720-734.
29. Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, et al. (2012) Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2alpha signaling in brown adipocytes. PLoS One 7: e34412.
30. Mebratu Y, Tesfaigzi Y (2009) How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle 8: 1168-1175.
31. Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ (2002) Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 277: 49676-49684. (Pubitemid 36014411)
32. Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, et al. (2001) Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med 7: 1133-1137. (Pubitemid 33010022)
33. Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, et al. (2002) Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 277: 21843-21850. (Pubitemid 34952337)
34. Kousteni S (2012) FoxO1, the transcriptional chief of staff of energy metabolism. Bone 50: 437-443.
35. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868. (Pubitemid 29165088)
36. Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, et al. (1999) Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398: 630-634. (Pubitemid 29183692)
37. Guo S, Rena G, Cichy S, He X, Cohen P, et al. (1999) Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 274: 17184-17192.
38. Rena G, Prescott AR, Guo S, Cohen P, Unterman TG (2001) Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. Biochem J 354: 605-612. (Pubitemid 32269724)
39. Folli F, Okada T, Perego C, Gunton J, Liew CW, et al. (2011) Altered insulin receptor signalling and beta-cell cycle dynamics in type 2 diabetes mellitus. PLoS One 6: e28050.
40. Alikhani M, Alikhani Z, Graves DT (2005) FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem 280: 12096-12102.
41. Kobayashi M, Kikuchi O, Sasaki T, Kim HJ, Yokota-Hashimoto H, et al. (2012) FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and betacell-specific FoxO1 knockout mice. Am J Physiol Endocrinol Metab 302: E603-613.
42. Zhang X, Gan L, Pan H, Guo S, He X, et al. (2002) Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J Biol Chem 277: 45276-45284.
43. Revuelta-Cervantes J, Mayoral R, Miranda S, Gonzalez-Rodriguez A, Fernandez M, et al. (2011) Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice. Am J Pathol 178: 1591-1604.
44. Belin de Chantemele EJ, Muta K, Mintz J, Tremblay ML, Marrero MB, et al. (2009) Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation 120: 753-763.
45. Sainz-Perez A, Gary-Gouy H, Gaudin F, Maarof G, Marfaing-Koka A, et al. (2008) IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression. J Immunol 181: 6051-6060.
46. Lu B, Wu H, Gu P, Du H, Shao J, et al. (2012) Improved glucose-stimulated insulin secretion by intra-islet inhibition of protein-tyrosine phosphatase 1B expression in rats fed a high-fat diet. J Endocrinol Invest 35: 63-70.