Structural fold and binding sites of the human Na+-phosphate cotransporter NaPi-II

Biophysical Journal

Volumn 106, Issue 6, 2014, Pages 1268-1279

  Fenollar Ferrer, Cristina ^a   Patti, Monica ^b   Knöpfel, Thomas ^b   Werner, Andreas ^c   Forster, Ian C ^b   Forrest, Lucy R ^a  

^a MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM PHOSPHATE COTRANSPORTER 2;

AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; MUTATION; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE II;

EID: 84896499827     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2014.01.043     Document Type: Article

References (70)

1. R. Shroff, D.A. Long, and C. Shanahan Mechanistic insights into vascular calcification in CKD J. Am. Soc. Nephrol. 24 2013 179 189
2. J. Biber, N. Hernando, and I. Forster Phosphate transporters and their function Annu. Rev. Physiol. 75 2013 535 550
3. I.C. Forster, and N. Hernando H. Murer Phosphate transporters of the SLC20 and SLC34 families Mol. Aspects Med. 34 2013 386 395
4. Y. Sabbagh, and H. Giral S.C. Schiavi Intestinal phosphate transport Adv. Chronic Kidney Dis. 18 2011 85 90
5. J. Biber, and N. Hernando H. Murer Regulation of phosphate transport in proximal tubules Pflugers Arch. 458 2009 39 52
6. I. Forster, and N. Hernando A. Werner Phosphate transporters in renal, gastrointestinal, and other tissues Adv. Chronic Kidney Dis. 18 2011 63 76
7. L. Beck, and A.C. Karaplis H.S. Tenenhouse Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities Proc. Natl. Acad. Sci. USA 95 1998 5372 5377 (Pubitemid 28208605)
8. J. Kenny, and M.M. Lees D. Bockenhauer Sotos syndrome, infantile hypercalcemia, and nephrocalcinosis: a contiguous gene syndrome Pediatr. Nephrol. 26 2011 1331 1334
9. D. Magen, and L. Berger K. Skorecki A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome N. Engl. J. Med. 362 2010 1102 1109
10. C. Bergwitz, and N.M. Roslin H. Juppner SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis Am. J. Hum. Genet. 78 2006 179 192 (Pubitemid 43157559)
11. A. Corut, and A. Senyigit A. Tolun Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis Am. J. Hum. Genet. 79 2006 650 656 (Pubitemid 44452742)
12. I.C. Forster, and N. Hernando H. Murer Phosphate transport kinetics and structure-function relationships of SLC34 and SLC20 proteins Curr. Top. Membr 70 2012 313 356
13. L.R. Forrest, R. Krämer, and C. Ziegler The structural basis of secondary active transport mechanisms Biochim. Biophys. Acta 1807 2011 167 188
14. L.R. Forrest, and Y.W. Zhang G. Rudnick Mechanism for alternating access in neurotransmitter transporters Proc. Natl. Acad. Sci. USA 105 2008 10338 10343
15. O. Jardetzky Simple allosteric model for membrane pumps Nature 211 1966 969 970
16. i cotransporter (NaPi-2) J. Gen. Physiol. 112 1998 1 18 (Pubitemid 28332297)
17. C. Ghezzi, H. Murer, and I.C. Forster Substrate interactions of the electroneutral Na+-coupled inorganic phosphate cotransporter (NaPi-IIc) J. Physiol. 587 2009 4293 4307
18. i cotransporter as a case study Prog. Biophys. Mol. Biol. 80 2002 69 108
19. J. Abramson, and E.M. Wright Structure and function of Na(+)-symporters with inverted repeats Curr. Opin. Struct. Biol. 19 2009 425 432
20. A. Yamashita, and S.K. Singh E. Gouaux Crystal structure of a bacterial homologue of Na+/Cl-dependent neurotransmitter transporters Nature 437 2005 215 223 (Pubitemid 41294479)
21. L.R. Forrest Structural biology. (Pseudo-)symmetrical transport Science 339 2013 399 401
22. L.R. Forrest, and G. Rudnick The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters Physiology (Bethesda) 24 2009 377 386
23. K. Khafizov, and C. Perez L.R. Forrest Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP Proc. Natl. Acad. Sci. USA 109 2012 E3035 E3044
24. R.D. Finn, J. Clements, and S.R. Eddy HMMER web server: interactive sequence similarity searching Nucleic Acids Res. 39 Web Server issue 2011 W29 W37
25. R.C. Edgar Search and clustering orders of magnitude faster than BLAST Bioinformatics 26 2010 2460 2461
26. Y. Liu, B. Schmidt, and D.L. Maskell MSAProbs: multiple sequence alignment based on pair hidden Markov models and partition function posterior probabilities Bioinformatics 26 2010 1958 1964
27. M. Stamm, and R. Staritzbichler L.R. Forrest Alignment of helical membrane protein sequences using AlignMe PLoS ONE 8 2013 e57731
28. M. Remmert, and A. Biegert J. Soding HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment Nat. Methods 9 2011 173 175
29. J. Söding Protein homology detection by HMM-HMM comparison Bioinformatics 21 2005 951 960 (Pubitemid 40467915)
30. S.F. Altschul, and T.L. Madden D.J. Lipman Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucleic Acids Res. 25 1997 3389 3402 (Pubitemid 27359211)
31. L.A. Kelley, and M.J. Sternberg Protein structure prediction on the Web: a case study using the Phyre server Nat. Protoc. 4 2009 363 371
32. M. Margelevicius, M. Laganeckas, and C. Venclovas COMA server for protein distant homology search Bioinformatics 26 2010 1905 1906
33. A. Šali, and T.L. Blundell Comparative protein modelling by satisfaction of spatial restraints J. Mol. Biol. 234 1993 779 815 (Pubitemid 24007801)
34. H. Ashkenazy, and E. Erez N. Ben-Tal ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids Nucleic Acids Res. 38 Web Server issue 2010 W529 W533
35. A. Ray, E. Lindahl, and B. Wallner Model quality assessment for membrane proteins Bioinformatics 26 2010 3067 3074
36. R.A. Laskowski, and M.W. Macarthur J.M. Thornton PROCHECK - a program to check the stereochemical quality of protein structures J. Appl. Cryst. 26 1993 283 291
37. E. Bossi, M.S. Fabbrini, and A. Ceriotti Exogenous protein expression in Xenopus oocytes: basic procedures Methods Mol. Biol. 375 2007 107 131 (Pubitemid 350183384)
38. O. Andrini, and A.K. Meinild I.C. Forster Lithium interactions with Na+-coupled inorganic phosphate cotransporters: insights into the mechanism of sequential cation binding Am. J. Physiol. Cell Physiol. 302 2012 C539 C554
39. i) cotransporter is codetermined by residues in two opposing linker regions J. Gen. Physiol. 120 2002 693 705 (Pubitemid 35332588)
40. R. Mancusso, and G.G. Gregorio D.N. Wang Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter Nature 491 2012 622 626
41. M.H. Saier Jr., and I.T. Paulsen Whole genome analyses of transporters in spirochetes: Borrelia burgdorferi and Treponema pallidum J. Mol. Microbiol. Biotechnol. 2 2000 393 399
42. +-coupled di- and tri-carboxylate/sulfate transporters Mol. Aspects Med. 34 2013 299 312
43. J.S. Lolkema, and D.J. Slotboom Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis J. Mol. Biol. 327 2003 901 909 (Pubitemid 36363699)
44. T.J. Crisman, and S. Qu L.R. Forrest Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats Proc. Natl. Acad. Sci. USA 106 2009 20752 20757
45. S. Ressl, and A.C. Terwisscha van Scheltinga C. Ziegler Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP Nature 458 2009 47 52
46. K. Khafizov, and R. Staritzbichler L.R. Forrest A study of the evolution of inverted-topology repeats from LeuT-fold transporters using AlignMe Biochemistry 49 2010 10702 10713
47. F. Kebbel, and M. Kurz H. Stahlberg Structure and substrate-induced conformational changes of the secondary citrate/sodium symporter CitS revealed by electron crystallography Structure 21 2013 1243 1250
48. J.D. Faraldo-Gómez, and L.R. Forrest Modeling and simulation of ion-coupled and ATP-driven membrane proteins Curr. Opin. Struct. Biol. 21 2011 173 179
49. T. Radanovic, and S.M. Gisler H. Murer Topology of the type IIa Na+/P(i) cotransporter J. Membr. Biol. 212 2006 41 49 (Pubitemid 46122152)
50. A. Karlin, and M.H. Akabas Substituted-cysteine accessibility method Methods Enzymol. 293 1998 123 145 (Pubitemid 29342485)
51. i cotransporter: II. Substrate interaction and voltage dependency of two functionally important sites J. Gen. Physiol. 124 2004 489 503 (Pubitemid 39506285)
52. K. Köhler, and I.C. Forster H. Murer Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter Am. J. Physiol. Renal Physiol. 282 2002 F687 F696
53. i) cotransporter J. Gen. Physiol. 117 2001 533 546 (Pubitemid 32552262)
54. G. Lambert, and M. Traebert H. Murer Studies on the topology of the renal type II NaPi-cotransporter Pflugers Arch. 437 1999 972 978 (Pubitemid 29210516)
55. rd) transmembrane domain of the type IIa sodium-phosphate co-transporter (NaPi-IIa) J. Membr. Biol. 206 2005 227 238 (Pubitemid 43199140)
56. +/Pi cotransporter: I. Cysteine scanning mutagenesis J. Gen. Physiol. 124 2004 475 488 (Pubitemid 39506284)
57. L.V. Virkki, H. Murer, and I.C. Forster Mapping conformational changes of a type IIb Na+/Pi cotransporter by voltage clamp fluorometry J. Biol. Chem. 281 2006 28837 28849 (Pubitemid 44507027)
58. C. Ghezzi, and A.K. Meinild I.C. Forster Voltage- and substrate-dependent interactions between sites in putative re-entrant domains of a Na(+)-coupled phosphate cotransporter Pflugers Arch. 461 2011 645 663
59. Reference deleted in proof.
60. i) cotransporter protein J. Gen. Physiol. 114 1999 637 652
61. i cotransporter: shedding light on substrate binding order J. Gen. Physiol. 127 2006 539 555
62. B.P. Pedersen, and H. Kumar R.M. Stroud Crystal structure of a eukaryotic phosphate transporter Nature 496 2013 533 536
63. R. ter Horst, and J.S. Lolkema Membrane topology screen of secondary transport proteins in structural class ST[3] of the MemGen classification. Confirmation and structural diversity Biochim. Biophys. Acta 1818 2012 72 81
64. i cotransport systems Am. J. Physiol. 280 2001 R301 R312
65. L.V. Virkki, and I.C. Forster H. Murer Substrate interactions in the human type IIa sodium-phosphate cotransporter (NaPi-IIa) Am. J. Physiol. Renal Physiol. 288 2005 F969 F981
66. O. Andrini, and C. Ghezzi I.C. Forster The leak mode of type II Na(+)-P(i) cotransporters Channels (Austin) 2 2008 346 357
67. F. Bezanilla How membrane proteins sense voltage Nat. Rev. Mol. Cell Biol. 9 2008 323 332 (Pubitemid 351430853)
68. M. Patti, C. Ghezzi, and I.C. Forster Conferring electrogenicity to the electroneutral phosphate cotransporter NaPi-IIc (SLC34A3) reveals an internal cation release step Pflugers Arch. 465 2013 1261 1279
69. T. Hessa, and H. Kim G. von Heijne Recognition of transmembrane helices by the endoplasmic reticulum translocon Nature 433 2005 377 381 (Pubitemid 40203311)
70. M. Custer, and M. Lotscher B. Kaissling Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry Am. J. Physiol. 266 1994 F767 F774