Voltage- and substrate-dependent interactions between sites in putative re-entrant domains of a Na+-coupled phosphate cotransporter

Pflugers Archiv European Journal of Physiology

Volumn 461, Issue 6, 2011, Pages 645-663

  Ghezzi, Chiara ^a   Meinild, Anne Kristine ^a   Murer, Heini ^a   Forster, Ian C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cross linking; Electrophysiology; Fluorescence; Fluorometry; Membrane transport; Na+ cotransporter; Phosphate cotransport; Voltage dependence; Xenopus laevis

Indexed keywords

1,10 PHENANTHROLINE COPPER; CYSTEINE; SODIUM PHOSPHATE COTRANSPORTER; SODIUM PHOSPHATE COTRANSPORTER 2A; SODIUM PHOSPHATE COTRANSPORTER 2B; SODIUM PHOSPHATE COTRANSPORTER 2C;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; CROSS LINKING; CYTOSOL; DISULFIDE BOND; ELECTROPHYSIOLOGY; FEMALE; FLUOROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; SITE DIRECTED MUTAGENESIS; STEADY STATE; VOLTAGE CLAMP;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CYSTEINE; FLOUNDER; MOLECULAR SEQUENCE DATA; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS; XENOPUS LAEVIS;

EID: 79958841991     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0948-z     Document Type: Article

References (47)

1. J Abramson EM Wright 2009 Structure and function of Na(+)-symporters with inverted repeats Curr Opin Struct Biol 19 4 425 432 10.1016/j.sbi.2009.06.002 19631523 10.1016/j.sbi.2009.06.002 1:CAS:528:DC%2BD1MXhtVKktbvK
2. JSI Abramson V Kasho G Verner HR Kaback S Iwata 2003 Structure and mechanism of the lactose permease of Escherichia coli Science 301 5633 610 615 12893935 10.1126/science.1088196 1:CAS:528:DC%2BD3sXlvVKns7k%3D (Pubitemid 36927939)
3. O Andrini C Ghezzi H Murer IC Forster 2008 The leak mode of type II Na(+)-P(i) cotransporters Channels (Austin) 2 5 346 357
4. +-coupled phosphate cotransporter Proc Natl Acad Sci U S A 102 12606 12611 16113079 10.1073/pnas.0505882102 1:CAS:528:DC%2BD2MXhtVSjsrjI (Pubitemid 41266406)
5. CL Careaga JJ Falke 1992 Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping J Mol Biol 226 4 1219 1235 1518053 10.1016/0022-2836(92)91063-U 1:CAS:528: DyaK38XlvVOktb4%3D
6. M Castagna A Soragna SA Mari M Santacroce S Bette PG Mandela G Rudnick A Peres VF Sacchi 2007 Interaction between lysine 102 and aspartate 338 in the insect amino acid cotransporter KAAT1 Am J Physiol Cell Physiol 293 4 C1286 C1295 17626242 10.1152/ajpcell.00190.2007 1:CAS:528:DC%2BD2sXht1WltbrJ (Pubitemid 47556729)
7. A Cha F Bezanilla 1998 Structural implications of fluorescence quenching in the Shaker K+ channel J Gen Physiol 112 4 391 408 9758859 10.1085/jgp.112.4.391 1:CAS:528:DyaK1cXmvVSrurc%3D (Pubitemid 28467597)
8. R Dutzler EB Campbell M Cadene BT Chait R MacKinnon 2002 X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity Nature 415 6869 287 294 11796999 10.1038/415287a 1:CAS:528:DC%2BD38XptlWksA%3D%3D (Pubitemid 34087544)
9. i cotransporter: II. Substrate interaction and voltage dependency of two functionally important sites J Gen Physiol 124 489 503 15504899 10.1085/jgp.200409061 1:CAS:528: DC%2BD2cXhtVentb%2FP (Pubitemid 39506285)
10. +/Pi cotransporter: I. Cysteine scanning mutagenesis J Gen Physiol 124 5 475 488 15504898 10.1085/jgp.200409060 1:CAS:528:DC%2BD2cXhtVentb%2FO (Pubitemid 39506284)
11. LR Forrest G Rudnick 2009 The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters Physiology (Bethesda) 24 377 386 1:CAS:528:DC%2BC3cXht1ais7o%3D
12. i cotransporter (NaPi-2) J Gen Physiol 112 1 1 18 9649580 10.1085/jgp.112.1.1 1:CAS:528:DyaK1cXks1Glu7w%3D (Pubitemid 28332297)
13. i cotransporter (NaPi-5) expressed in Xenopus laevis oocytes J Membr Biol 160 1 9 25 9351888 10.1007/s002329900291 1:CAS:528:DyaK2sXntlyhtL8%3D (Pubitemid 27491718)
14. C Ghezzi H Murer IC Forster 2009 Substrate interactions of the electroneutral Na+-coupled inorganic phosphate cotransporter (NaPi-IIc) J Physiol 587 Pt 17 4293 4307 19596895 10.1113/jphysiol.2009.175596 1:CAS:528:DC%2BD1MXhtFKksb7M
15. SM Gisler S Kittanakom D Fuster V Wong M Bertic T Radanovic RA Hall H Murer J Biber D Markovich OW Moe I Stagljar 2008 Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system Mol Cell Proteomics 7 7 1362 1377 18407958 10.1074/mcp.M800079-MCP200 1:CAS:528:DC%2BD1cXotlygu74%3D (Pubitemid 352038278)
16. H Hilfiker O Hattenhauer M Traebert I Forster H Murer J Biber 1998 Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine Proc Natl Acad Sci U S A 95 24 14564 14569 9826740 10.1073/pnas.95.24.14564 1:CAS:528:DyaK1cXns1Gltrc%3D (Pubitemid 28549407)
17. XMM Huang 1991 A time-efficient, linear-space local similarity algorithm Adv Appl Math 12 337 357 10.1016/0196-8858(91)90017-D
18. K Kohler IC Forster G Lambert J Biber H Murer 2000 The functional unit of the renal type IIa Na+/Pi cotransporter is a monomer J Biol Chem 275 34 26113 26120 10859311 10.1074/jbc.M003564200 1:CAS:528:DC%2BD3cXmt1OksL4%3D
19. K Kohler IC Forster G Stange J Biber H Murer 2002 Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter Am J Physiol 282 4 F687 F696 1:CAS:528:DC%2BD38XivVemtr4%3D
20. i cotransporter is codetermined by residues in two opposing linker regions J Gen Physiol 120 693 703 12407080 10.1085/jgp.20028645 (Pubitemid 35332588)
21. i cotransporter Pflügers Arch Eur J Physiol 446 2 203 210 (Pubitemid 36683584)
22. HPC Krishnamurthy E Gouaux 2009 Unlocking the molecular secrets of sodium-coupled transporters Nature 459 7245 347 355 19458710 10.1038/nature08143 1:CAS:528:DC%2BD1MXmtFKmsLs%3D
23. i cotransporter protein J Gen Physiol 114 5 637 652 10532962 10.1085/jgp.114.5.637 1:CAS:528:DC%2BD3cXmtFOmsbc%3D (Pubitemid 29523189)
24. i cotransporter J Gen Physiol 117 6 533 546 11382804 10.1085/jgp.117.6.533 1:CAS:528: DC%2BD3MXkslKru7g%3D (Pubitemid 32552262)
25. MA Larkin G Blackshields NP Brown R Chenna PA McGettigan H McWilliam F Valentin IM Wallace A Wilm R Lopez JD Thompson TJ Gibson DG Higgins 2007 ClustalW and ClustalX version 2 Bioinformatics 23 21 2947 2948 17846036 10.1093/bioinformatics/btm404 1:CAS:528:DC%2BD2sXhtlaqsL%2FM (Pubitemid 350162903)
26. HP Larsson AV Tzingounis HP Koch MP Kavanaugh 2004 Fluorometric measurements of conformational changes in glutamate transporters Proc Natl Acad Sci U S A 101 11 3951 3956 15001707 10.1073/pnas.0306737101 1:CAS:528: DC%2BD2cXis1Knsrw%3D (Pubitemid 38381083)
27. M Li HA Lester 2002 Early fluorescence signals detect transitions at mammalian serotonin transporters Biophys J 83 1 206 218 12080113 10.1016/S0006-3495(02)75162-X 1:CAS:528:DC%2BD38XlsVWisrs%3D (Pubitemid 34694732)
28. JS Lolkema DJ Slotboom 2003 Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis J Mol Biol 327 5 901 909 12662917 10.1016/S0022-2836(03)00214-6 1:CAS:528:DC%2BD3sXitlWgsLk%3D (Pubitemid 36363699)
29. JS Lolkema DJ Slotboom 2008 The major amino acid transporter superfamily has a similar core structure as Na+-galactose and Na+-leucine transporters Mol Membr Biol 25 6-7 567 570 19031293 10.1080/09687680802541177 1:CAS:528:DC%2BD1cXhsVentLbM
30. DD Loo BA Hirayama EM Gallardo JT Lam E Turk EM Wright 1998 Conformational changes couple Na+ and glucose transport Proc Natl Acad Sci U S A 95 13 7789 7794 9636229 10.1073/pnas.95.13.7789 1:CAS:528:DyaK1cXktFCgsLY%3D (Pubitemid 28293332)
31. +/glucose cotransporter Biochemistry 41 4 1250 1258 11802724 10.1021/bi011661r 1:CAS:528:DC%2BD38XmvVw%3D (Pubitemid 34083777)
32. L Parent S Supplisson DD Loo EM Wright 1992 Electrogenic properties of the cloned Na+/glucose cotransporter: II. A transport model under nonrapid equilibrium conditions.[erratum appears in J Membr Biol 1992 Nov;130(2):203] J Membr Biol 125 1 63 79 1294062 1:CAS:528:DyaK38Xht1ens74%3D
33. T Radanovic SM Gisler J Biber H Murer 2006 Topology of the type IIa Na+/P(i) cotransporter J Membr Biol 212 1 41 49 10.1007/s00232-006-0033-2 17206517 10.1007/s00232-006-0033-2 1:CAS:528:DC%2BD2sXkslartw%3D%3D (Pubitemid 46122152)
34. S Ravera LV Virkki H Murer IC Forster 2007 Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements American Journal of Physiology-Cell Physiology 293 2 C606 C620 17494632 10.1152/ajpcell.00064.2007 1:CAS:528:DC%2BD2sXpt12rtLg%3D (Pubitemid 47235175)
35. RM Ryan AD Mitrovic RJ Vandenberg 2004 The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway J Biol Chem 279 20 20742 20751 14982939 10.1074/jbc.M304433200 1:CAS:528:DC%2BD2cXjvV2ns7w%3D (Pubitemid 38656471)
36. E Screpanti C Hunte 2007 Discontinuous membrane helices in transport proteins and their correlation with function J Struct Biol 159 2 261 267 S1047-8477(07)00031-7 17350860 10.1016/j.jsb.2007.01.011 1:CAS:528: DC%2BD2sXot1ygsrc%3D (Pubitemid 47095395)
37. Z Tao YW Zhang A Agyiri G Rudnick 2009 Ligand effects on cross-linking support a conformational mechanism for serotonin transport J Biol Chem 284 49 33807 33814 19837674 10.1074/jbc.M109.071977 1:CAS:528:DC%2BD1MXhsVymu7vM
38. LV Virkki J Biber H Murer IC Forster 2007 Phosphate transporters: a tale of two solute carrier families Am J Physiol Renal Physiol 293 3 F643 F654 17581921 10.1152/ajprenal.00228.2007 1:CAS:528:DC%2BD2sXhtVyhtLbI (Pubitemid 47403335)
39. rd transmembrane domain of the type IIa sodium-phosphate co-transporter (NaPi-IIa) J Membr Biol 206 3 227 238 16456717 10.1007/s00232-005-0796-x 1:CAS:528:DC%2BD28XhtFWmtr0%3D (Pubitemid 43199140)
40. LV Virkki IC Forster J Biber H Murer 2005 Substrate interactions in the human type IIa sodium-phosphate cotransporter (NaPi-IIa) Am J Physiol 288 F969 F981 10.1152/ajprenal.00293.2004 1:CAS:528:DC%2BD2MXktlSgt70%3D (Pubitemid 40569763)
41. LV Virkki IC Forster N Hernando J Biber H Murer 2003 Functional characterization of two naturally occurring mutations in the human sodium-phosphate cotransporter type IIa J Bone Miner Res 18 12 2135 2141 14672348 10.1359/jbmr.2003.18.12.2135 1:CAS:528:DC%2BD3sXhtVSqtr%2FP (Pubitemid 37463307)
42. i cotransporter by voltage clamp fluorometry J Biol Chem 281 28837 28849 16887801 10.1074/jbc.M603861200 1:CAS:528:DC%2BD28XpvFanur0%3D (Pubitemid 44507027)
43. i cotransporter: shedding light on substrate binding order J Gen Physiol 127 539 555 16636203 10.1085/jgp.200609496 1:CAS:528:DC%2BD28XltVWntbc%3D
44. i cotransport systems Am J Physiol 280 2 R301 R312 1:CAS:528:DC%2BD3MXjtVWks7w%3D
45. A Yamashita SK Singh T Kawate Y Jin E Gouaux 2005 Crystal structure of a bacterial homologue of Na+/Cl-dependent neurotransmitter transporters Nature 437 7056 215 223 16041361 10.1038/nature03978 1:CAS:528:DC%2BD2MXpslekurY%3D (Pubitemid 41294479)
46. DBO Yernool Y Jin E Gouaux 2004 Structure of a glutamate transporter homologue from Pyrococcus horikoshii Nature 431 7010 811 818 15483603 10.1038/nature03018 1:CAS:528:DC%2BD2cXotl2ktL4%3D (Pubitemid 39434071)
47. E Zomot Y Zhou BI Kanner 2005 Proximity of transmembrane domains 1 and 3 of the gamma-aminobutyric acid transporter GAT-1 inferred from paired cysteine mutagenesis J Biol Chem 280 27 25512 25516 15905165 10.1074/jbc.M503864200 1:CAS:528:DC%2BD2MXlslyluro%3D (Pubitemid 40962256)