Systems toxicology approach to understand the kinetics of benzo(a)pyrene uptake, biotransformation, and dna adduct formation in a liver cell model

Chemical Research in Toxicology

Volumn 27, Issue 3, 2014, Pages 443-453

  Madureira, Danielle J ^a,b   Weiss, Frederik T ^a   Van Midwoud, Paul ^b   Helbling, Damian E ^a,d   Sturla, Shana J ^b   Schirmer, Kristin ^a,b,c  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c EPFL   (Switzerland)

^d Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CATALYSIS; CELL COUNT; CELL CYCLE ARREST; CELL DENSITY; CELL FRACTIONATION; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DNA ADDUCT; DNA REPAIR; HEPATOMA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID SCINTILLATION COUNTING; LIVER CELL; LIVER FUNCTION; MOUSE; NONHUMAN;

ANIMALS; BENZO(A)PYRENE; BIOTRANSFORMATION; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DNA DAMAGE; ENVIRONMENTAL POLLUTANTS; HEPATOCYTES; KINETICS; MICE; MODELS, BIOLOGICAL; TANDEM MASS SPECTROMETRY;

EID: 84896378471     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400446q     Document Type: Article

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