Biological monitoring and biochemical effect monitoring of exposure to polycyclic aromatic hydrocarbons

International Archives of Occupational and Environmental Health

Volumn 70, Issue 6, 1997, Pages 365-377

  Angerer, J ^a   Mannschreck, C ^a   Gundel J ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

32P postlabeling; Biological biochemical effect monitoring; DNA adducts; Immunoassays; Metabolites; Polycyclic aromatic hydrocarbons; Protein adducts

Indexed keywords

POLYCYCLIC AROMATIC HYDROCARBON;

BIOLOGICAL MONITORING; BLOOD SAMPLING; CANCER RISK; DNA ADDUCT; ENVIRONMENTAL EXPOSURE; FLUORESCENCE SPECTROSCOPY; GAS CHROMATOGRAPHY; HEALTH HAZARD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; MASS SPECTROMETRY; METABOLITE; OCCUPATIONAL EXPOSURE; REVIEW; URINALYSIS; WORKPLACE;

BENZO(A)PYRENE; BIOLOGICAL MARKERS; BLOOD PROTEINS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; HUMANS; IMMUNOASSAY; ISOTOPE LABELING; OCCUPATIONAL EXPOSURE; PHENANTHRENES; POLYCYCLIC HYDROCARBONS, AROMATIC; PYRENES; SPECTROMETRY, FLUORESCENCE;

EID: 0030828549     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004200050231     Document Type: Review

References (69)

1. IARC (1983) Monographs on the evaluation on the carcinogenic risk of chemicals to humans, vol 32. Polynuclear aromatic compounds, part 1. Chemicals, environmental and experimental data. IARC, Lyon
2. Koch R (ed) (1991) Umweltchemikalien, 2nd edn. Verlag Chemie, Weinheim, pp 338-347
3. Deutsche Forschungsgemeinschaft (1996) List of MAK and BAT values 1996. Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Report 32. Verlag Chemie, Weinheim
4. American Conference of Governmental Industrial Hygienists [ACGIH] (1996) Threshold limit values for chemical substances and physical agents and biological exposure indices. ACGIH, Cincinnati
5. BMA (1996) TRgS 150, Unmittelbarer Hautkontakt mit Gefahrstoffen, die durch die Haut resorbiert werden können - hautresorbierbare Gefahrstoffe. In: Technische Regeln und Richtlinien zur Verordnung über gefährliche Stoffe. Bekanntmachung des BMA von 6/96, Bundesarbeitsblatt 6/96
6. Angerer J, Gündel J (1996) Biomonitoring and occupational medicine. Possibilities and limitations. Ann 1st Super Sanita 32: 199-206
7. Angerer J, Rüdiger H, Schaller KH, Lehnen G (1992) Biological Monitoring als diagnostisches Instrument bei der Prävention chemisch bedingter Berufskrebse. In: Horst A, Norpoth K, Verkoyen C (eds) Krebsrisiken am Arbeitsplatz. Springer, Berlin Heidelberg, pp 219-245
8. Dell'Omo M, Lauwerys RR (1993) Adducts to macromolecules in the biological monitoring of workers exposed to polycyclic aromatic hydrocarbons. CRC Crit Rev Toxicol 23: 111-126
9. 32P postlabeling assay for aromatic DNA adducts in white blood cells of iron foundry workers. Mutat Res 224: 485-492
10. Hemminki K, Grzybowska E, Chorazy M, Twardowska-Saucha K, Sroczynski JW, Putman KL, Randerath K, Phillips DH, Hewer A, Santella RM, Perera FP (1990) DNA adducts in humans related to occupational and environmental exposure to aromatic compounds. In: Vainio H, Sorsa M, McMichael AJ (eds) Complex mixtures and cancer risk. IARC, Lyon, pp 181-192
11. Hemminiki K (1995) DNA adducts in biomonitoring. Toxicol Lett 77: 227-229
12. Øvrebø S, Haugen A, Fjeldstad PE, Hemminiki K, Szyfter K (1994) Biological monitoring of exposure to polycyclic aromatic hydrocarbon in an electrode paste plant. J Occup Med 36: 303-310
13. 32P postlabeling of aromatic DNA adducts in white blood cells from iron foundry workers. Mutat Res 204: 531-541
14. Reddy MV, Hemminiki K, Randerath K (1991) Postlabeling analysis of polycyclic aromatic hydrocaron-DNA adducts in white blood cells of foundry workers. J Toxicol Environ Health 34: 177-185
15. Perera FP, Dickey C, Santella R, O'Neill JP, Albertini RJ, Oilman R, Tsai WY, Mooney LA, Savela, K, Hemminiki K (1994) Carcinogen-DNA adducts and gene mutation in foundry workers with low-level exposure to polycyclic aromatic hydrocarbons, Carcinogenesis 15: 2905-2910
16. 32P postlabeling analysis of DNA adducts in humans: adduct distribution and method improvement. Mutat Res 313: 269-276
17. Hemminiki K, Grzybowska E, Chorazy M, Twardowska-Saucha K, Sroczynski JW, Putman KL, Randerath K, Phillips DH, Hewer A (1990) Aromatic DNA adducts in white blood cells of coke workers. Int Arch Occup Environ Heath 62: 467-470
18. Van Schooten FJ, Jongeneelen FJ, Hillebrand MJX, Van Leeuwen FE, De Looff AJA, Dijkmans APG, Van Rooij JGM, Den Engelse L, Kriek E (1995) Polycyclic aromatic hydrocarbon-DNA adducts in white blood cell DNA and 1-hydroxypyrene in the urine from aluminium workers: relation with job category and synergistic effect of smoking. Cancer Epidemiol Biomarkers Prev 4: 69-77
19. Øvrebø S, Haugen A, Hemminiki K, Szyfler K, Drablos PA, Skogland MS (1995) Studies of biomarkers in aluminium workers occupationally exposed to polycyclic aromatic hydrocarbons, Cancer Detect Prev 19: 258-267
20. 32P postlabeling. Scand J Work Environ Health 16: 135-143
21. Hemminiki K, Randerath K, Reddy MV, Putman KL, Santella MR, Perera FP, Young T-L (1990) Postlabeling and immunoassay analysis of polycyclic aromatic hydrocarbons - adducts of deoxyribonucleic acid in white blood cells of foundry workers. Scand J Work Environ Health 16: 158-162
22. Øvrebø S, Haugen A, Phillips DH, Hewer A (1992) Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from coke oven workers: correlation with job categories. Cancer Res 52: 1510-1514
23. 32P postlabeling analysis of DNA adducts in different populations. Toxicol Lett 77: 299-307
24. 32P Postlabeling detection of aromatic DNA adducts in peripheral blood lymphocytes from aluminium production plant workers. Mutat Res 260: 89-98
25. 32P postlabeling and enzyme-linked immunosorbent assay. Environ Health Perspect 99: 307-309
26. Hemminiki K, Zhang LF, Krüger J, Autrup H, Törnqvist M, Norbcek H-E (1994) Exposure of bus and taxi drivers to urban air pollutants as measured by DNA and protein adducts. Toxicol Lett 72: 171-174
27. Nielsen PS, Pater Nde, Okkels H, Autrup H (1996) Environmental air pollution and DNA adducts in Copenhagen bus drivers - effect of GSTM1 and NAT2 genotypes on adduct levels. Carcinogenesis 17: 1021-1027
28. Schoket B, Poirier MC, Vincze I (1995) Biomonitoring of genotoxic exposure in aluminium plant workers by determination of DNA adducts in human peripheral blood lymphocytes. Sci Total Environ 163: 153-163
29. Nielsen PS, Andreassen A, Farmer PB, Øvrebø S, Autrup H (1996) Biomonitoring of diesel exhaust-exposed workers. DNA and hemoglobin adducts and urinary 1-hydroxypyrene as markers of exposure. Toxicol Lett 86: 27-37
30. Darcey JD, Everson RB, Putman KL, Randerath K (1992) DNA adducts and exposure to burning oil. Lancet 339: 489
31. Fuchs J, Hengstler JG, Boettler G, Oesch F (1996) Primary DNA damage in peripheral mononuclear blood cells of workers exposed to bitumen-based products. Int Arch Occup Environ Heath 68: 141-146
32. Schwendt G (1992) Taschenatlas der Analytik. Thieme, Stuttgart
33. Santella RM, Hemminiki K, Tang D-L, Paik M, Ottman R, Young TL, Savela K, Vodickov L, Dickey C, Whyatt R, Perea FP (1993) Polycyelic aromatic hydrocarbon-DNA adducts in white blood cells and urinary 1-hydroxypyrene in foundry workers. Cancer Epidemiol Biomarkers Prev 2: 59-62
34. Perera FP, Hemminiki K, Young TL, Brenner G. Kelly G, Santella RM (1988) Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Cancer Res 48: 2288-2291
35. Assennato G, Ferri GM, Foa V, Strickland P, Poirier M, Pozzoli L, Cottica D (1993) Correlation between PAH airborne concentration and PAH-DNA adduct levels in cokeoven workers. Int Arch Occup Environ Heath 65: 143-145
36. Van Schooten FJ, Van Leeuwen FE, Hillebrand MJX, De Riijke ME, Hart AAM, Van Veen HG, Oosterink S, Kriek E (1990) Determination of benzo(a)pyrene diol epoxid-DNA adducts in white blood cell DNA from coke-oven workers: the impact of smoking. J Natl Cancer Inst 82: 927-933
37. Shamsuddin AK, Sinopoli NT, Hemminiki K, Boesch RR, Harris CC (1985) Detection of benzo(a)pyrene: DNA adducts in human white blood cells. Cancer Res 45: 66-68
38. Harris CC, Vahakangas K, Newman MJ, Trivers GE, Shamsuddin A, Sinopoli N, Mann DL, Wright WE (1985) Detection of benzo(a)pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci USA 82: 6672-6676
39. Liou S-H, Jacobsen-Kram D, Poirier MC, Nguyen D, Strickland PT, Tockman MS (1989) Biological monitoring of fire fighters: sister chromatid exchange and polycyclic aromatic hydrocarbon-DNA adducts in peripheral blood cells. Cancer Res 49: 4929-4935
40. Day BW, Singh K (1994) Analysis of hemoglobin adducts by fluorescence spectroscopy. Methods Enzymol 231: 674-681
41. Haugen A, Becher G, Benestad C, Vahakangas K, Trivers GE, Newman MJ, Harris CC (1986) Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons. Cancer Res 46: 4178-4183
42. Weston A, Rowe ML, Manchaster DK, Farmer PB, Mann DL, Harris CC (1989) Fluorescence and mass spectral evidence for the formation of benzo(a)pyrene anti-diol-epoxide-DNA and - hemoglobin adducts in humans. Carcinogenesis 10: 251-257
43. Vahakangas K, Pyy L, Yrjänheikki E (1992) Assessment of PAH-exposure among coke oven workers. Pharmacogenetics 2: 304-308
44. Rojas M, Alexandrov K, Auburtin G, Wastiaux-Denamur A, Mayer L, Mahieu B, Sebastien P, Bartsch H (1995) Anti-benzo(a)pyrene diolepoxide-DNA adduct levels in peripheral mononuclear cells from coke oven workers and the enhancing effect of smoking. Carcinogenesis 16: 1373-1376
45. Shugart L (1985) Quantitating exposure to chemical carcinogens: in vivo alkylation of hemoglobin by benzo(a)pyrene. Toxicology 34: 211-220
46. Ferreira M Jr Tas S, Dell'Omo M, Goormans G, Buchet JP, Lauwerys R (1994) Determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin in workers exposed to polycyclic aromatic hydrocarbons. Occup Environ Med 51: 451-455
47. Omland O, Sherson D, Hansen ÅM, Sigsgaard T, Autrup H, Overgaard E (1994) Exposure of iron foundry workers to polycyclic aromatic hydrocarbons: benzo(a)pyrene-albumin adducts and 1-hydroxypyrene as biomarkers for exposure. Occup Environ Med 51: 513-518
48. Sherson DM, Sabro P, Sigsgaard T, Johansen F, Autrup H (1990) Biological monitoring of foundry workers exposed to polycyclic aromatic hydrocarbons. Br J Ind Med 47: 448-453
49. Tas S, Buchet JP, Lauwerys R (1994) Determinants of benzo(a)pyrene diol epoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons. Int Arch Occup Environ Heath 66: 343-348
50. Lee BM, Baoyun Y, Herbert R, Hemminiki K, Perera FP, R. Santella RM (1991) Immunologic measurement of polycyclic aromatic hydrocarbon-albumin adducts in foundry workers and roofers. Scand J Work Environ Health 17: 190-194
51. Grimmer G, Dettbarn G, Jacob J (1993) Biomonitoring of polycyclic aromatic hydrocarbons in highly exposed coke plant workers by measurement of urinary phenanthrene and pyrene metabolites (phenols and dihydrodiols). Int Arch Environ Health 65: 189-199
52. Jongeneelen FJ, Anzion RBM (1991) 1-hydroxypyrene. In: Angerer J, Schaller KH (eds) Analyses of hazardous substances in biological materials, vol 3. VCH, Weinheim
53. Buchet JP, Gennart JP, Mercado-Calderon F, Delavignette JP, Cupers L, Lauwreys R (1992) Evaluation of exposure to polycyclic aromatic hydrocarbons in a coke production and a graphite electrode manufacturing plant: assessment of urinary excretion of 1-hydroxypyrene as a biological indicator of exposure. Br J Ind Med 49: 761-768
54. Jongeneelen FJ, Leeuwen FE van, Oosterink S, Anzion RBM, Loop F van der, Bos RP, van Veen HG van (1990) Ambient and biological monitoring of coke oven workers: determinants of the internal dose of polycyclic aromatic hydrocarbons. Br J Ind Med 47: 454-461
55. Elovaara E, Heikkilä P, Pyy L, Mutanen P, Riihimäki V (1995) Significance of dermal and respiratory uptake in creosote workers: exposure to polycyclic aromatic hydrocarbons and urinary excretion of 1-hydroxypyrene. Occup Environ Med 52: 196-203
56. Ferreira M Jr Buchet JP, Burrion JB, Moro J, Cupers L, Delavignette JP, Jacques J, Lauwerys R (1994) Determinants of urinary thioethers, D-glucaric acid and mutagenicity after exposure to polycyclic aromatic hydrocarbons assessed by air monitoring and measurement of 1-hydroxypyrene in urine: a cross-sectional study in workers of coke and graphite-electrode-producing plants. Int Arch Occup Environ Health 65: 329-338
57. Boogaard PJ, Sittert NJ van (1994) Exposure to polycyclic aromatic hydrocarbons in petrochemical industries by measurement of urinary 1-hydroxypyrene. Occup Environ Med 51: 250-258
58. Jongeneelen FJ, Bos RP, Anzion RBM, Theuws LG, Henderson PT (1986) Biological monitoring of polycyclic aromatic hydrocarbons. Scand J Work Environ Health 12: 137-143
59. Heikkilä P, Luotamo M, Pyy L, Riihimäki V (1995) Urinary 1-naphthol and 1-pyrenol as indicators of exposure to coal tar products. Int Arch Occup Environ Heath 67: 211-217
60. Jongeneelen FJ (1992) Biological exposure limit for occupational exposure to coal tar pitch volatiles at coke ovens. Int Arch Occup Environ Heath 63: 511-516
61. Van Rooij JGM, Bodelier-Bade MM, Jongeneelen FJ (1993) Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers. Br J Ind Med 50: 623-632
62. Jongeneelen FJ, Anzion RBM, Scheepers PTJ, Bos RP, Henderson PT, Nijenhuis EH, Veenstra SJ, Brouns RME, Winkes A (1988) 1-Hydroxypyrene in urine as a biological indicator of exposure to polycyclic aromatic hydrocarbons in several work environments. Ann Occup Hyg 32: 35-43
63. Øvrebø S, Haugen A, Farmer PB, Anderson D (1995) Evaluation of biomarkers in plasma, blood, and urine samples from coke oven workers: significance of exposure to polycyclic aromatic hydrocarbons. Occup Environ Med 52: 750-756
64. Göen T, Gündel J, Schaller K-H, Angerer J (1995) The elimination of 1-hydroxypyrene in the urine of the general population and workers with different occupational exposures to PAH. Sci Total Environ 163: 195-201
65. Lintelmann J, Hellemann C, Kettrup A (1994) Coupled-column high-performance liquid Chromatographic method for the determination of four metabolites of polycyclic hydrocarbons, 1-, 4-, and 9-hydroxyphenanthrene and 1-hydroxypyrene, in urine. J Chromatogr 660: 67-73
66. Angerer J, Mannschreck C, Gündel J (1997) Occupational exposure to polycyclic aromatic hydrocarbons in a graphite-electrode-producing plant: biological monitoring of 1-hydroxypyrene and monohydroxylated metabolites of phenanthrene. Int Arch Occup Environ Health 69: 323-331
67. Mannschreck C, Gündel J, Angerer J (1996) Belastung gegenüber PAHs an verschiedenen Arbeitsplätzen - Biomonitoring von monohydroxylierten Metaboliten. Vortrag, 36. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin, Wiesbaden, 6.-9.5,1996
68. Gündel J, Mannschreck C, Büttner K, Ewers U, Angerer J (1996) Urinary levels of 1-hydroxypyrene, 1-, 2+9-, 3- and 4-hydroxyphenanthrene in females living in an industrial area of Germany. Arch Environ Contam Toxicol 31: 585-590
69. Martin F, Hoepfner I, Scherer G, Adelkofer F, Dettbarn G, Grimmer G(1989) Urinary excretion of hydroxyphenanthrenes after intake of polycyclic aromatic hydrocarbons. Environ Int 15: 41-47