DIGE-based protein expression analysis of B[a]P-exposed hepatoma cells reveals a complex stress response including alterations in oxidative stress, cell cycle control, and cytoskeleton motility at toxic and subacute concentrations

Journal of Proteome Research

Volumn 10, Issue 2, 2011, Pages 379-393

  Dautel, Franziska ^a   Kalkhof, Stefan ^a   Trump, Saskia ^a   Michaelson, Jacob ^b   Beyer, Andreas ^b   Lehmann, Irina ^a   Von Bergen, Martin ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Aryl hydrocarbon receptor (Ahr); Benzo a pyrene (B a P); DIGE; Human protein reference database (HPRD); Oxidative stress; Protein expression analysis

Indexed keywords

BENZO[A]PYRENE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL MOTILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; DIFFERENCE GEL ELECTROPHORESIS; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GEL ELECTROPHORESIS; HEPATOMA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLLUTANT; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DATABASE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ANIMALS; APOPTOSIS; BENZO(A)PYRENE; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CYTOSKELETON; DATABASES, PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; MICE; OXIDATIVE STRESS; PROTEIN INTERACTION MAPPING; PROTEOME; SIGNAL TRANSDUCTION; TOXICITY TESTS;

MURINAE;

EID: 79955370604     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100723d     Document Type: Article

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