The circadian clock regulates rhythmic activation of the NRF2/glutathionemediated antioxidant defense pathway to modulate pulmonary fibrosis

Genes and Development

Volumn 28, Issue 6, 2014, Pages 548-560

  Pekovic Vaughan, Vanja ^a   Gibbs, Julie ^a   Yoshitane, Hikari ^b   Yang, Nan ^a   Pathiranage, Dharshika ^a   Guo, Baoqiang ^a   Sagami, Aya ^b   Taguchi, Keiko ^c   Bechtold, David ^a   Loudon, Andrew ^a   Yamamoto, Masayuki ^c   Chan, Jefferson ^d   van der Horst, Gijsbertus T J ^e   Fukada, Yoshitaka ^b   Meng, Qing Jun ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Bleomycin; Circadian clock; Glutathione; NRF2; Pulmonary fibrosis

Indexed keywords

ANTIOXIDANT; BLEOMYCIN; GLUTATHIONE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CIRCADIAN RHYTHM; ENZYME ACTIVATION; FEMALE; FIBROSING ALVEOLITIS; IN VIVO STUDY; LUNG FIBROSIS; LUNG INJURY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS;

BLEOMYCIN; CIRCADIAN CLOCK; GLUTATHIONE; NRF2; PULMONARY FIBROSIS;

ANIMALS; ANTICARCINOGENIC AGENTS; BLEOMYCIN; CIRCADIAN CLOCKS; E-BOX ELEMENTS; FEMALE; GENE EXPRESSION REGULATION; GLUTATHIONE; HOMEOSTASIS; ISOTHIOCYANATES; LUNG; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PULMONARY FIBROSIS;

EID: 84896339411     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.237081.113     Document Type: Article

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