Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

Journal of Clinical Investigation

Volumn 123, Issue 12, 2013, Pages 5389-5400

  Musiek, Erik S ^a   Lim, Miranda M ^b   Yang, Guangrui ^c   Bauer, Adam Q ^a   Qi, Laura ^a   Lee, Yool ^c   Roh, Jee Hoon ^a   Ortiz Gonzalez, Xilma ^d   Dearborn, Joshua T ^a   Culver, Joseph P ^a   Herzog, Erik D ^e   Hogenesch, John B ^c   Wozniak, David F ^a   Dikranian, Krikor ^a   Giasson, Benoit I ^f   Weaver, David R ^g   Holtzman, David M ^a   FitzGerald, Garret A ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Division of Nuclear Medicine   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e WASHINGTON UNIVERSITY   (United States)

^f UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CYCLOOXYGENASE 2; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; MESSENGER RNA; NESTIN; NEUROPROSTANE; PER1 PROTEIN; PER2 PROTEIN; PHTHALIC ACID DIBUTYL ESTER; PROTEIN BMAL1; REGULATOR PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTOSIS; BRAIN CORTEX; BRAIN TISSUE; CELL DEATH; CELL METABOLISM; CIRCADIAN RHYTHM; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOLOGY; DISEASE EXACERBATION; E BOX ELEMENT; ENZYME ACTIVE SITE; GENE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; INDEL MUTATION; LIQUID CHROMATOGRAPHY; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEURONAL PAS DOMAIN PROTEIN 2; NEUROPATHOLOGY; NONHUMAN; OSCILLATION; PERIOD CIRCADIAN CLOCK 1; PERIOD CIRCADIAN CLOCK 2; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REDOX GENE; REDOX HOMEOSTASIS; REGULATORY MECHANISM; REPRESSOR GENE; RETROSPLENIAL CORTEX; SLEEP WAKING CYCLE; TANDEM MASS SPECTROMETRY; TRANSMISSION ELECTRON MICROSCOPY;

AGING; ANIMALS; ARNTL TRANSCRIPTION FACTORS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN; CEREBRAL CORTEX; CIRCADIAN RHYTHM; CLOCK PROTEINS; CORPUS STRIATUM; GENE EXPRESSION REGULATION; GLIOSIS; HIPPOCAMPUS; HOMEOSTASIS; LOCOMOTION; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NEUROLOGIC MUTANTS; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PERIOD CIRCADIAN PROTEINS; RNA INTERFERENCE; SLEEP DISORDERS, CIRCADIAN RHYTHM;

EID: 84890015150     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI70317     Document Type: Article

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