Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats

Journal of Neuroscience

Volumn 34, Issue 12, 2014, Pages 4148-4160

  Hickey, Louise ^a   Li, Yong ^a   Fyson, Sarah J ^a   Watson, Thomas C ^e   Perrins, Ray ^a   Hewinson, James ^d   Teschemacher, Anja G ^a   Furue, Hidemasa ^c   Lumb, Bridget M ^a   Pickering, Anthony E ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e SORBONNE UNIVERSITÉ   (France)

Author keywords

ChannelRhodopsin2; Endogenous analgesia; Lentiviral vector; Locus ceruleus; Noradrenergic; Pain

Indexed keywords

RHODOPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CHROMOPHORE ASSISTED LIGHT INACTIVATION; CONTROLLED STUDY; EVOKED RESPONSE; FLUORESCENCE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LOCUS CERULEUS; MALE; NOCICEPTIVE STIMULATION; NONHUMAN; NORADRENERGIC NERVE; OPTOGENETICS; PERCEPTIVE THRESHOLD; PONTINE NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPIKE WAVE; STEREOTACTIC PROCEDURE; WESTERN BLOTTING; WITHDRAWAL REFLEX;

CHANNELRHODOPSIN2; ENDOGENOUS ANALGESIA; LENTIVIRAL VECTOR; LOCUS CERULEUS; NORADRENERGIC; PAIN;

ANIMALS; HOT TEMPERATURE; LOCUS COERULEUS; MALE; NEURONS; NOCICEPTION; OPTOGENETICS; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR;

EID: 84896287507     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4835-13.2014     Document Type: Article

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