Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii

Journal of Physiology

Volumn 551, Issue 2, 2003, Pages 589-599

  Pickering, Anthony E ^a   Boscan, Pedro ^b   Paton, Julian F R ^c  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ARECAIDINE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; SUBSTANCE P; 4 AMINOBUTYRIC ACID A RECEPTOR;

ADRENERGIC RECEPTOR BLOCKING; ADRENERGIC SYSTEM; ARTICLE; CHOLINERGIC RECEPTOR BLOCKING; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DECEREBRATION; HINDLIMB; IN VIVO STUDY; MALE; MICROINJECTION; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; PERFUSION; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; STIMULUS RESPONSE; TACHYCARDIA; VAGUS TONE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CARDIAC VAGAL BAROREFLEX; EVOKED RESPONSE; PARASYMPATHETIC BAROREFLEX; SYMPATHETIC BAROREFLEX; SYMPATHETIC NERVE; VAGUS NERVE;

ANIMALS; BAROREFLEX; GABA AGONISTS; HEART; HINDLIMB; ISONICOTINIC ACIDS; MALE; MICROINJECTIONS; NOCICEPTORS; PAIN; PARASYMPATHETIC NERVOUS SYSTEM; PHYSICAL STIMULATION; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; SOLITARY NUCLEUS; SUBSTANCE P; SYMPATHETIC NERVOUS SYSTEM; TACHYCARDIA; VAGUS NERVE;

EID: 0141746256     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.046615     Document Type: Article

References (35)

1. Barraco IRA (1994). Nucleus of the Solitary Tract. CRC Press, Boca Raton, FL, USA.
2. Blessing WW (1997). Anatomy of the lower brainstem. In The Lower Brainstem and Bodily Homeostasis, pp. 29-101. Oxford University Press, New York.
3. Boscan P, Allen AM & Paton JF (2001). Baroreflex inhibition of cardiac sympathetic outflow is attenuated by angiotensin II in the nucleus of the solitary tract. Neuroscience 103, 153-160.
4. Boscan P, Kasparov S & Paton JFR (2002a). Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex. Eur J Neurosci 16, 907-920.
5. Boscan P & Paton JF (2001). Role of the solitary tract nucleus in mediating nociceptive evoked cardiorespiratory responses. Auton Neurosci 86, 170-182.
6. Boscan P, Pickering AE & Paton JF (2002b). The nucleus of the solitary tract: an integrating station for nociceptive and cardiorespiratory afferents. Exp Physiol 87, 259-266.
7. Deuchars J, Li YW, Kasparov S & Paton JF (2000). Morphological and electrophysiological properties of neurones in the dorsal vagal complex of the rat activated by arterial baroreceptors. J Comp Neurol 417, 233-249.
8. Esteves FOG, Kaye JC, McWilliam PN, Lima D & Batten TF (2001a). Immunohistochemical profiles of spinal lamina I neurones retrogradely labelled from the nucleus tractus solitarii in rat suggest excitatory projections. Neuroscience 104, 523-538.
9. Esteves F, Lima D & Coimbra A (1993). Structural types of spinal cord marginal (lamina I) neurons projecting to the nucleus of the tractus solitarius in the rat. Somatosens Mot Res 10, 203-216.
10. Esteves FOG, Tavares I, Almeida A, Batten TF, McWilliam PN & Lima D (2001b). Projection sites of superficial and deep spinal dorsal horn cells in the nucleus tractus solitarii of the rat. Brain Res 921, 195-205.
11. Fan W, Schild JH & Andresen MC (1999). Graded and dynamic reflex summation of myelinated and unmyelinated rat aortic baroreceptors. Am J Physiol 277, R748-756.
12. Gauriau C & Bernard JF (2002). Pain pathways and parabrachial circuits in the rat. Exp Physiol 87, 251-258.
13. Harlan RE, Garcia MM & Krause JE (1989). Cellular localization of substance P- and neurokinin A-encoding preprotachykinin mRNA in the female rat brain. J Comp Neurol 287, 179-212.
14. Hilton SM (1982). The defence-arousal system and its relevance for circulatory and respiratory control. J Exp Biol 100, 159-174.
15. Janig W (1985). Systemic and specific autonomic reactions in pain: efferent, afferent and endocrine components. Eur J Anaesthesiol 2, 319-346.
16. Ljungdahl A, Hokfelt T & Nilsson G (1978). Distribution of substance P-like immunoreactivity in the central nervous system of the rat - I. Cell bodies and nerve terminals. Neuroscience 3, 861-943.
17. Machado BH, Castania JA, Bonagamba LG & Salgado HC (2000). Neurotransmission of autonomic components of aortic baroreceptor afferents in the NTS of awake rats. Am J Physiol 279, H67-75.
18. Massari VJ, Shirahata M, Johnson TA, Lauenstein JM & Gatti PJ (1998). Substance P immunoreactive nerve terminals in the dorsolateral nucleus of the tractus solitarius: roles in the baroreceptor reflex. Brain Res 785, 329-340.
19. Menetrey D & Basbaum AI (1987). Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation. J Comp Neurol 255, 439-450.
20. Mitchell JH, Kaufman MP & Iwamoto GA (1983). The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu Rev Physiol 45, 229-242.
21. Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S & Mizuno N (1994). Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol 347, 249-274.
22. Nosaka S & Murata K (1989). Somatosensory inhibition of vagal baroreflex bradycardia: afferent nervous mechanisms. Am J Physiol 257, R829-838.
23. Paton JFR (1996). A working heart-brainstem preparation of the mouse. J Neurosci Methods 65, 63-68.
24. Paton JF, Boscan P, Murphy D & Kasparov S (2001). Unravelling mechanisms of action of angiotensin II on cardiorespiratory function using in vivo gene transfer. Acta Physiol Scand 173, 127-137.
25. Perez H, Ruiz S, Inostroza H & Perretta M (1992). Substance P depresses bioelectrical responses evoked in the nucleus tractus solitarii: interaction with gamma-aminobutyric acid-ergic neurons. Eur J Pharmacol 213, 435-437.
26. Pezzone MA, Lee WS, Hoffman GE, Pezzone KM & Rabin BS (1993). Activation of brainstem catecholaminergic neurons by conditioned and unconditioned aversive stimuli as revealed by c-Fos immunoreactivity. Brain Res 608, 310-318.
27. Pickering AE, Boscan P & Paton JFR (2003). Differential modulation of baroreflex autonomic outputs by noxious stimulation: a role for substance P in the nucleus of the solitary tract. J Physiol 547, P, C12.
28. Pickering AE, Waki H, Headley PM & Paton JFR (2002). Investigation of systemic bupivacaine toxicity using the in situ perfused working heart-brainstem preparation of the rat. Anesthesiology 97, 1550-1556.
29. Potts JT, Fuchs IE, Li J, Leshnower B & Mitchell JH (1999). Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anaesthetized cats. J Physiol 514, 829-841.
30. Quest JA & Gebber GL (1972). Modulation of baroreceptor reflexes by somatic afferent nerve stimulation. Am J Physiol 222, 1251-1259.
31. Sapru HN (1994). Transmitter/receptor mechanisms in cardiovascular control by the NTS; excitatory amino acids, acetylcholine and substance P. In Nucleus of the Solitary Tract, ed. Barraco, A.R.A., pp. 267-287. CRC Press, Boca Raton, FL, USA.
32. Seagard JL, Dean C & Hopp FA (2000). Modulation of the carotid baroreceptor reflex by substance P in the nucleus tractus solitarius. J Auton Nerv Syst 78, 77-85.
33. Todd AJ, McGill MM & Shehab SA (2000). Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur J Neurosci 12, 689-700.
34. Toney GM & Mifflin SW (2000). Sensory modalities conveyed in the hindlimb somatic afferent input to nucleus tractus solitarius. J Appl Physiol 88, 2062-2073.
35. Torvik A (1956). Afferent connections to the sensory trigeminal nuclei, the nucleus of the solitary tract and adjacent structures. An experimental study in the rat. J Comp Neurol 106, 51-142.