Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury

Pain

Volumn 154, Issue 9, 2013, Pages 1680-1690

  Hughes, S W ^a   Hickey, L ^a   Hulse, R P ^a   Lumb, B M ^a   Pickering, A E ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Complex regional pain syndrome; Descending control; Neuropathic pain; Norepinephrine

Indexed keywords

ATIPAMEZOLE; CLONIDINE; KETAMINE; MEDETOMIDINE; PRAZOSIN; REBOXETINE; YOHIMBINE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONOLOGY; COLD; CONTROLLED STUDY; HEAT; HINDLIMB; HYPERALGESIA; HYPERSENSITIVITY; INTRATHECAL CATHETER; MALE; NERVE INJURY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; NORADRENERGIC NERVE; NORADRENERGIC SYSTEM; PHENOTYPE; PONTOSPINAL NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; TIBIAL NERVE; TIBIAL NERVE INJURY;

COMPLEX REGIONAL PAIN SYNDROME; DESCENDING CONTROL; NEUROPATHIC PAIN; NOREPINEPHRINE;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; DOPAMINE BETA-HYDROXYLASE; ELECTROMYOGRAPHY; FUNCTIONAL LATERALITY; HYPERALGESIA; MALE; NEURALGIA; PAIN MEASUREMENT; PAIN THRESHOLD; PONS; PRAZOSIN; RATS; RATS, WISTAR; SPINAL CORD; TIBIAL NEUROPATHY; TIME FACTORS; YOHIMBINE;

EID: 84881662373     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.05.010     Document Type: Article

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