Phox2 genes - From patterning to connectivity

Current Opinion in Genetics and Development

Volumn 12, Issue 4, 2002, Pages 435-440

  Brunet, Jean François ^a   Pattyn, Alexandre ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PHOX2A; TRANSCRIPTION FACTOR PHOX2B; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; NBPHOX PROTEIN; NERVE PROTEIN; PHOX2A PROTEIN, HUMAN;

AGENESIS; BRAIN DEVELOPMENT; CELL TYPE; DEVELOPMENTAL STAGE; GENE FUNCTION; GENE MAPPING; MOLECULAR DYNAMICS; MOTONEURON; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STEM CELL; TRANSCRIPTION REGULATION; ANIMAL; BRAIN; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; HUMAN; MORPHOGENESIS; NERVE CELL; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ANIMALS; BODY PATTERNING; BRAIN; CELL DIFFERENTIATION; HOMEODOMAIN PROTEINS; HUMANS; NERVE TISSUE PROTEINS; NEURONS; TRANSCRIPTION FACTORS;

EID: 0036668282     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00322-2     Document Type: Review

References (53)

1. Evolution of homeobox genes: Q50 Paired-like genes founded the Paired class
2. The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system
3. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
4. A possible link between cell adhesion receptors, homeodomain proteins and neuronal identity
5. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype
6. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a
7. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
8. Specification of the central noradrenergic phenotype by the homeobox gene Phox2b
9. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development
10. Noradrenaline is essential for mouse fetal development
11. Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells
12. The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons
13. Development of noradrenergic neurons in the Zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a
14. The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs)
15. Noradrenergic-specific transcription of the dopamine β-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites
16. Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine b-hydroxylase gene
17. The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes
18. The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein
19. A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes
20. Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription
21. Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system
22. Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3
23. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system
24. Expression of HAND gene products may be sufficient for the differentiation of avian neural crest-derived cells into catecholaminergic neurons in culture
25. Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons
26. Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons
27. Induction of the epibranchial placodes
28. Homozygous mutations in ARIX(PHOX2A) result in congenital fibrosis of the extraocular muscles type 2
29. Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b
30. The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity
31. BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development
32. Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity
33. Deconstructing cell determination: Proneural genes and neuronal identity
34. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
35. Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons
36. MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity
37. The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification
38. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
39. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
40. Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
41. Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways
42. Sonic hedgehog control of size and shape in midbrain pattern formation
43. Structural and functional characterization of the 5' upstream promoter of the human Phox2a gene: Possible direct transactivation by transcription factor Phox2b
44. Sp proteins and Phox2b regulate the expression of the human Phox2a gene
45. The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans
46. Role of the target in the pathfinding of facial visceral motor axons
47. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets
48. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord
49. Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
50. ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
51. Proprioceptor pathway development is dependent on Math1
52. Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
53. A single rostro-caudal colonisation of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret and p75, and by explants grown under the kidney capsule or in organ culture