Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: An in vivo patch-clamp analysis of analgesic mechanisms

Pain

Volumn 155, Issue 3, 2014, Pages 617-628

  Funai, Yusuke ^a,b   Pickering, Anthony Edward ^c   Uta, Daisuke ^a   Nishikawa, Kiyonobu ^b   Mori, Takashi ^b   Asada, Akira ^b   Imoto, Keiji ^a,d   Furue, Hidemasa ^a,d  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

Author keywords

Alpha2 adrenoceptor; Dexmedetomidine; Noradrenaline; Patch clamp analysis; Spinal cord

Indexed keywords

DEXMEDETOMIDINE; PRAZOSIN;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN STEM; CONTROLLED STUDY; IN VIVO STUDY; LOCUS CERULEUS; MALE; MEMBRANE CURRENT; NOCICEPTION; NONHUMAN; NORADRENERGIC SYSTEM; PATCH CLAMP TECHNIQUE; POSTSYNAPTIC INHIBITION; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION;

ALPHA2 ADRENOCEPTOR; DEXMEDETOMIDINE; NORADRENALINE; PATCH-CLAMP ANALYSIS; SPINAL CORD;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADRENERGIC NEURONS; ANALGESIA; ANALGESICS, NON-NARCOTIC; ANIMALS; DEXMEDETOMIDINE; MALE; NEURAL INHIBITION; PATCH-CLAMP TECHNIQUES; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTIC TRANSMISSION;

EID: 84894260806     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.12.018     Document Type: Article

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