Novel ruthenium complexes ligated with 4-anilinoquinazoline derivatives: Synthesis, characterisation and preliminary evaluation of biological activity

European Journal of Medicinal Chemistry

Volumn 77, Issue , 2014, Pages 110-120

  Ji, Liyun ^a,b   Zheng, Wei ^a,b   Lin, Yu ^a,b   Wang, Xiuli ^c   Lü, Shuang ^a,b   Hao, Xiang ^a,b   Luo, Qun ^a,b   Li, Xianchan ^a,b   Yang, Ling ^c   Wang, Fuyi ^a,b  

^a PEKING UNIVERSITY   (China)

^b INSTITUTE OF CHEMISTRY   (China)

^c DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Anticancer agents; EGFR inhibitors; MCF 7; Multi targeting; Ruthenium complexes

Indexed keywords

4 (3' CHLORO 4' FLUOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANTINEOPLASTIC AGENT; DIMETHYL SULFOXIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; QUINAZOLINE DERIVATIVE; RUTHENIUM CHLORIDE DIMETHYL SULFOXIDE 4 (3' CHLORO 4' FLUOROANILINO) 6 [2 (1H IMIDAZOL 1 YL)ETHOXY] 7 METHOXYQUINAZOLINE; RUTHENIUM CHLORIDE DIMETHYL SULFOXIDE 4 (3' CHLORO 4' FLUOROANILINO) 6 [2 (2 AMINOETHYL)AMINOETHOXY] 7 METHOXYQUINAZOLINE; RUTHENIUM CHLORIDE DIMETHYL SULFOXIDE 5 (6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO)QUINOLIN 8 OL; RUTHENIUM CHLORIDE DIMETHYL SULFOXIDE N (BENZO[D]IMIDAZOL 4 YL) 6,7 DIMETHOXYQUINAZOLIN 4 AMINE; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; ORGANOMETALLIC COMPOUND; RUTHENIUM;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; SPECTROMETRY; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MCF 7 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RUTHENIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896141627     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.062     Document Type: Article

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