In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Chemistry - A European Journal

Volumn 14, Issue 29, 2008, Pages 9046-9057

  Berger, Isabella ^a   Hanif, Muhammad ^a   Nazarov, Alexey A ^a,b   Hartinger, Christian G ^a,b   John, Roland O ^a   Kuznetsov, Maxim L ^c   Groessl, Michael ^a   Schmitt, Frederic ^d   Zava, Olivier ^d   Biba, Florian ^a   Arion, Vladimir B ^a   Galanski, Markus ^a   Jakupec, Michael A ^a   Juillerat Jeanneret, Lucienne ^d   Dyson, Paul J ^b   Keppler, Bernhard K ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b EPFL   (Switzerland)

^c INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^d UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Bioinorganic chemistry; Cancer chemotherapeutics; Drug design; P ligands; Ruthenium

Indexed keywords

BIOCHEMISTRY; CARBOHYDRATES; CELL CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIGANDS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC COMPOUNDS; ORGANOMETALLICS; RUTHENIUM; SODIUM CHLORIDE; SOLUTIONS; SULFUR COMPOUNDS; X RAY DIFFRACTION ANALYSIS;

ANTICANCER ACTIVITIES; AQUATION; AQUEOUS SOLUTIONS; BIOINORGANIC CHEMISTRY; CANCER CHEMOTHERAPEUTICS; CELL LINES; CYTOTOXIC COMPOUNDS; DFT CALCULATIONS; DINUCLEAR SPECIES; DRUG DESIGN; ESI MASS SPECTROMETRIES; HUMAN CANCER CELLS; IN VITRO; IN VITRO STUDIES; ISOPROPYLIDENE; METABOLIZATION; NACL SOLUTIONS; NMR SPECTROSCOPIES; ORGANO-METALLIC; P LIGANDS; PHOSPHITE LIGANDS; RUTHENIUM COMPLEXES;

RUTHENIUM COMPOUNDS;

ANTINEOPLASTIC AGENT; CARBOHYDRATE; LIGAND; RUTHENIUM DERIVATIVE;

ARTICLE; CARBOHYDRATE METABOLISM; CELL LINE; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HUMAN; HYDROLYSIS; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CARBOHYDRATE METABOLISM; CARBOHYDRATES; CELL LINE; CELL SURVIVAL; HUMANS; HYDROLYSIS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANIC CHEMISTRY PHENOMENA; RUTHENIUM COMPOUNDS;

EID: 55049083403     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200801032     Document Type: Article

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