(Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1972-1975

  Biersack, B ^a   Zoldakova, M ^a   Effenberger, K ^a   Schobert, R ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Anticancer drugs; EGFR inhibitor; Multi drug resistance; Ruthenium complexes; Tyrphostin

Indexed keywords

DICHLORIDO(4 CYMENE)[3 (1' CYANO 2' (3'' HYDROXY 4'' METHOXYPHENYL)ETHENYL)PYRIDINE]RUTHENIUM; DICHLORIDO(4 CYMENE)[3 (1' CYANO 2' (3'',4'' DMETHOXYPHENY)ETHENYL)PYRIDINE]RUTHENIUM; DICHLORIDO(TOLUENE)[3 (1' CYANO 2' (3'' HYDROXY 4'' METHOXYPHENYL)ETHENYL)PYRIDINE]RUTHENIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GUAIACOL; MAMMALIAN TARGET OF RAPAMYCIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TYRPHOSTIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL; CARCINOMA CELL; CELL STRAIN HL 60; COMPLEX FORMATION; CONTROLLED STUDY; DNA METHYLATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MELANOMA CELL; METALLATION; MULTIDRUG RESISTANCE; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION;

ANIMALS; CELL PROLIFERATION; DNA; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; MALE; ORGANOMETALLIC COMPOUNDS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RUTHENIUM; SALMON; SPERMATOZOA; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; TYRPHOSTINS;

EID: 77949486360     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.040     Document Type: Article

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