Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: Discovery of potent and selective protein kinase inhibitors

Journal of the American Chemical Society

Volumn 128, Issue 3, 2006, Pages 877-884

  Bregman, Howard ^a   Carroll, Patrick J ^a   Meggers, Eric ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; METAL ANALYSIS; MOLECULAR DYNAMICS; RUTHENIUM; SCANNING; SYNTHESIS (CHEMICAL);

BINDING SITES; FUNCTIONAL GROUPS; LIGANDS; METAL CENTERS;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; PROTEIN KINASE; PROTEIN KINASE GSK3A; PROTEIN KINASE INHIBITOR; PROTEIN KINASE MSK1; PROTEIN KINASE PIM 1; RUTHENIUM; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL BINDING; COMPLEX FORMATION; DRUG SYNTHESIS; INHIBITION KINETICS; LIGAND BINDING; MOLECULAR MODEL; THREE DIMENSIONAL IMAGING;

CARBAZOLES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GLYCOGEN SYNTHASE KINASE 3; KINETICS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PROTEIN KINASE INHIBITORS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; RUTHENIUM; STAUROSPORINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 31444446334     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja055523r     Document Type: Article

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