Synthesis and Chemical-Pharmacological Characterization of the Antimetastatic NAMI-A-Type Ru(III) Complexes (Hdmtp)[trans-RuCl 4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidine)

Journal of Medicinal Chemistry

Volumn 47, Issue 5, 2004, Pages 1110-1121

  Velders, Aldrik H ^a,d   Bergamo, Alberta ^b   Alessio, Enzo ^c   Zangrando, Ennio ^c   Haasnoot, Jaap G ^a   Casarsa, Claudia ^b   Cocchietto, Moreno ^b   Zorzet, Sonia ^c   Sava, Gianni ^b,c  

^a LEIDEN UNIVERSITY   (Netherlands)

^b Callerio Foundation   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

^d Molteni Farmaceutici   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5,7 DIMETHYL 1,2,4 TRIAZOLO[1,5 A]PYRIMIDINE; ANTIMETASTATIC AGENT; DIMETHYL SULFOXIDE; GELATINASE B; IMIDAZOLE DERIVATIVE; PRODRUG; PYRIMIDINE DERIVATIVE; RUTHENIUM DERIVATIVE; SODIUM DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CELL CYCLE; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; EDEMA; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROLYSIS; IC 50; KIDNEY TUBULE; LIVER PARENCHYMA; METASTASIS INHIBITION; MOLECULAR STABILITY; MOUSE; NONHUMAN; TUMOR NECROSIS; X RAY DIFFRACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HYDROLYSIS; KIDNEY; LIVER; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MAMMARY NEOPLASMS, ANIMAL; MATRIX METALLOPROTEINASE 9; MICE; MOLECULAR STRUCTURE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 1242331871     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030984d     Document Type: Article

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