Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics

Drug Metabolism and Disposition

Volumn 42, Issue 4, 2014, Pages 500-510

  Achour, Brahim ^a   Russell, Matthew R ^a   Barber, Jill ^a   Rostami Hodjegan, Amin ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CERTARA UK LIMITED   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B7; XENOBIOTIC AGENT;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENOTYPE; HEREDITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CLEARANCE; LIVER MICROSOME; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS;

ADULT; AGED; ALCOHOL DRINKING; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; MICROSOMES, LIVER; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROTEOMICS; SENSITIVITY AND SPECIFICITY; SEX CHARACTERISTICS; SMOKING;

EID: 84896120092     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.055632     Document Type: Article

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