Metallothionein Suppresses Angiotensin II-Induced Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation, Nitrosative Stress, Apoptosis, and Pathological Remodeling in the Diabetic Heart

Journal of the American College of Cardiology

Volumn 52, Issue 8, 2008, Pages 655-666

  Zhou, Guihua ^a,c   Li, Xiaokun ^c   Hein, David W ^a   Xiang, Xilin ^a   Marshall, James P ^a   Prabhu, Sumanth D ^a,b   Cai, Lu ^a,c  

^a University of Louisville School of Medicine   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

angiotensin II; cardiomyocyte apoptosis; diabetic cardiomyopathy; metallothionein; NADPH oxidase; nitrosative damage

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; APOCYNIN; CASPASE 3; ENDOTHELIN 1; METALLOTHIONEIN; PEROXYNITRITE; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; HEART PROTECTION; MOUSE; NEWBORN; NITROSATIVE STRESS; NONHUMAN; PRIORITY JOURNAL;

ANGIOTENSIN II; ANIMALS; APOPTOSIS; CARDIOMYOPATHIES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC ANGIOPATHIES; FIBROSIS; HYPERTROPHY; METALLOTHIONEIN; MICE; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; NADP; OXIDATIVE STRESS; VENTRICULAR REMODELING;

EID: 48849086702     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.05.019     Document Type: Article

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