Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3

Diabetologia

Volumn 49, Issue 9, 2006, Pages 2174-2184

  An, D ^a   Kewalramani, G ^a   Chan, J K Y ^a   Qi, D ^a   Ghosh, S ^a   Pulinilkunnil, T ^a   Abrahani, A ^a   Innis, S M ^a   Rodrigues, B ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

AMPK; Apoptosis; Cardiomyocyte; Metformin; Palmitic acid

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CASPASE 3; CERAMIDE; HOE 33342; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LACTATE DEHYDROGENASE; LACTIC ACID; METFORMIN; PALMITIC ACID; SYNAPSIN I;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID OXIDATION; GLYCOLYSIS; HEART MUSCLE CELL; MALE; MUSCLE CELL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; STAINING;

ACETYL-COA CARBOXYLASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; GLYCOLYSIS; HYDROGEN-ION CONCENTRATION; L-LACTATE DEHYDROGENASE; LACTIC ACID; MALE; METFORMIN; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; PALMITIC ACID; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 33746752740     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0338-9     Document Type: Article

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