Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model

Toxicology Letters

Volumn 219, Issue 1, 2013, Pages 65-76

  Jiang, Xin ^a,b   Zhang, Chi ^b,c   Xin, Ying ^b,d   Huang, Zhifeng ^c   Tan, Yi ^b,c   Huang, Yadong ^e   Wang, Yonggang ^b,f   Feng, Wenke ^c   Li, Xiaokun ^c   Li, Wei ^a   Qu, Yaqin ^a   Cai, Lu ^a,b,c  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b University of Louisville School of Medicine   (United States)

^c WENZHOU MEDICAL UNIVERSITY   (China)

^d JILIN UNIVERSITY   (China)

^e JINAN UNIVERSITY   (China)

^f CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Bax Bcl2; Endoplasmic reticulum stress; FGF21; Mitochondrial cell death; Testicular apoptosis; Type 1 diabetes

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 12; CASPASE 8; FIBROBLAST GROWTH FACTOR 21; PROTEIN BAX; PROTEIN BCL 2; STREPTOZOCIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DIET RESTRICTION; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MITOCHONDRIAL TOXICITY; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SPERMATOGENESIS; TESTIS CELL;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST GROWTH FACTORS; FOOD DEPRIVATION; GENE DELETION; IN SITU NICK-END LABELING; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; SPERMATOGENESIS; TESTIS;

MUS;

EID: 84875608972     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.02.022     Document Type: Article

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