Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

Diabetologia

Volumn 57, Issue 4, 2014, Pages 819-831

  Sasaki, Tsutomu ^a   Kikuchi, Osamu ^a   Shimpuku, Mayumi ^a   Susanti, Vina Yanti ^a   Yokota Hashimoto, Hiromi ^a   Taguchi, Ryo ^b   Shibusawa, Nobuyuki ^b   Sato, Takashi ^a   Tang, Lijun ^c   Amano, Kosuke ^a   Kitazumi, Tomoya ^a   Kuroko, Mitsutaka ^a   Fujita, Yuki ^a   Maruyama, Jun ^a   Lee, Yong Soo ^a   Kobayashi, Masaki ^a   Nakagawa, Takashi ^d   Minokoshi, Yasuhiko ^c   Harada, Akihiro ^a,e   Yamada, Masanobu ^b   Kitamura, Tadahiro ^a   more..

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^d UNIVERSITY OF TOYAMA   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

AgRP; Brown adipose tissue; Diet induced obesity; Energy expenditure; Food intake; Hypothalamus; Leptin sensitivity; POMC; Sympathetic activity

Indexed keywords

AGOUTI RELATED PROTEIN; COMPLEMENTARY DNA; LEPTIN; LIOTHYRONINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; NORADRENALIN; PROOPIOMELANOCORTIN; PROTEIN TYROSINE PHOSPHATASE 1B; SIRTUIN 1; SUPPRESSOR OF CYTOKINE SIGNALING;

ACETYLATION; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BRAIN; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CALORIMETRY; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FIBROBLAST; FOOD INTAKE; GENOTYPE; HISTOLOGY; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; LOCOMOTION; MASS SPECTROMETRY; MOUSE; NERVE CELL; NONHUMAN; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECTUM TEMPERATURE; SYMPATHETIC TONE; WEIGHT GAIN;

ANIMALS; CALORIMETRY, INDIRECT; GENOTYPE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LEPTIN; MALE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; SIRTUIN 1; WEIGHT GAIN;

EID: 84896074276     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3140-5     Document Type: Article

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