Identification of novel alternative splicing events in the huntingtin gene and assessment of the functional consequences using structural protein homology modelling

Journal of Molecular Biology

Volumn 426, Issue 7, 2014, Pages 1428-1438

  Hughes, Alis C ^a   Mort, Matthew ^a   Elliston, Lyn ^a   Thomas, Rhian M ^a   Brooks, Simon P ^b   Dunnett, Stephen B ^b   Jones, Lesley ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

alternative transcripts; Huntington's disease; pathogenesis; protein modelling; RNA processing

Indexed keywords

ANTIBODY; HUNTINGTIN ANTIBODY; UNCLASSIFIED DRUG; ISOPROTEIN; STRUCTURAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EXON; GENE; GENE EXPRESSION; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUNTINGTIN GENE; HUNTINGTON CHOREA; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; WESTERN BLOTTING; ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; BRAIN; BRAIN REGION; BRAIN TISSUE; HUMAN TISSUE; WILD TYPE;

ANIMALIA; MAMMALIA; MUS;

ALTERNATIVE TRANSCRIPTS; HUNTINGTON'S DISEASE; PATHOGENESIS; PROTEIN MODELLING; RNA PROCESSING;

ALTERNATIVE SPLICING; ANIMALS; FEMALE; HUMANS; MALE; MICE; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84895921060     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.12.028     Document Type: Article

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