Laurate permeates the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29/B6 via opening the tight junctions by reversible relocation of claudin-5

Pharmaceutical Research

Volumn 31, Issue 9, 2014, Pages 2539-2548

  Dittmann, Isabel ^a   Amasheh, Maren ^a   Krug, Susanne M ^a   Markov, Alexander G ^b   Fromm, Michael ^a   Amasheh, Salah ^c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

absorption enhancer; drug uptake; epithelial cell; tight junctions

Indexed keywords

BIOTIN; CLAUDIN 5; DEXTRAN; FLUORESCEIN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; LAURIC ACID DERIVATIVE; SUCCINIMIDE DERIVATIVE; SULFOSUCCINIMIDYL-2-(BIOTINAMIDO)ETHYL-1,3-DITHIOPROPIONATE;

ANALOGS AND DERIVATIVES; CELL MEMBRANE PERMEABILITY; DRUG EFFECTS; HT 29 CELL LINE; HUMAN; INTESTINE MUCOSA; METABOLISM; PERMEABILITY; TIGHT JUNCTION;

BIOTIN; CELL MEMBRANE PERMEABILITY; CLAUDIN-5; DEXTRANS; FLUORESCEIN; FLUORESCEIN-5-ISOTHIOCYANATE; HT29 CELLS; HUMANS; INTESTINAL MUCOSA; LAURATES; PERMEABILITY; SUCCINIMIDES; TIGHT JUNCTIONS;

EID: 84895911350     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1350-2     Document Type: Article

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